(Q36392408)

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Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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author name string

Christine L Le Maitre

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Judith A Hoyland

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Anthony J Freemont

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 January 2007

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Arthritis Research and Therapy

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

R83

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

https://scigraph.springernature.com/pub.10.1186/ar2282

0 references

Gelatinolytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9 in rat brain after implantation of 9L rat glioma cells

1 reference

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Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2006.

1 reference

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30 September 2017

Biological treatment strategies for disc degeneration: potentials and shortcomings

1 reference

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30 September 2017

Disc regeneration: why, when, and how.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

Intervertebral disc degeneration in relation to the COL9A3 and the IL-1ss gene polymorphisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

Nucleus pulposus replacement: basic science and indications for clinical use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta

1 reference

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30 September 2017

Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

Why a mechanical disc?

1 reference

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30 September 2017

Low back pain: an economic assessment in the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

Comparative gene expression profiling of normal and degenerative discs: analysis of a rabbit annular laceration model

1 reference

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30 September 2017

Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

Matrix metalloproteinases in the human intervertebral disc: role in disc degeneration and scoliosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

30 September 2017

Human disc degeneration is associated with increased MMP 7 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

21 September 2018

The MMP activity in developing rat molar roots and incisors demonstrated by in situ zymography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

21 September 2018

A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

21 September 2018

Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

21 September 2018

Intervertebral disc cell-mediated mesenchymal stem cell differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

21 September 2018

Alterations in biochemical components of extracellular matrix in intervertebral disc herniation: role of MMP-2 and TIMP-2 in type II collagen loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

21 September 2018

Positive feedback loop of interleukin-1beta upregulating production of inflammatory mediators in human intervertebral disc cells in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

21 September 2018

Studies of human intervertebral disc cell function in a constrained in vitro tissue culture system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

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Possible association of interleukin 1 gene locus polymorphisms with low back pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

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Localization of cathepsins D, K, and L in degenerated human intervertebral discs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

21 September 2018

IL-1beta sensitizes intervertebral disc annulus cells to fluid-induced shear stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2206387

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The economic burden of back pain in the UK.

1 reference

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21 September 2018

Matrix metalloproteinases: the clue to intervertebral disc degeneration?

1 reference

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Transfer of genes to chondrocytic cells of the lumbar spine. Proposal for a treatment strategy of spinal disorders by local gene therapy

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mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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inferred from PubMed ID database lookup

Nerve growth factor expression and innervation of the painful intervertebral disc

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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based on heuristic

inferred from PubMed ID database lookup

Induction of matrix metalloproteinase-2 and -3 activity in ovine nucleus pulposus cells grown in three-dimensional agarose gel culture by interleukin-1beta: a potential pathway of disc degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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inferred from PubMed ID database lookup

Structural, psychological, and genetic influences on low back and neck pain: A study of adult female twins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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inferred from PubMed ID database lookup

Immunolocalization of MMP-19 in the human intervertebral disc: implications for disc aging and degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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based on heuristic

inferred from PubMed ID database lookup

Up-regulated expression of matrilysin and neutrophil collagenase in human herniated discs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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inferred from PubMed ID database lookup

The regulation of MMPs and TIMPs in cartilage turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental studies on the effects of recombinant human matrix metalloproteinases on herniated disc tissues--how to facilitate the natural resorption process of herniated discs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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inferred from PubMed ID database lookup

Radiographic features of lumbar disc degeneration and self-reported back pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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based on heuristic

inferred from PubMed ID database lookup

Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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inferred from PubMed ID database lookup

Interleukin 1 Polymorphisms and Intervertebral Disc Degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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based on heuristic

inferred from PubMed ID database lookup

The role of interleukin-1 on proteoglycan metabolism of rabbit annulus fibrosus cells cultured in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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based on heuristic

inferred from PubMed ID database lookup

Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase-3 production by human degenerated intervertebral disc

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin G in degenerating and healthy discal tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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based on heuristic

inferred from PubMed ID database lookup

Endothelial expression of nitric oxide synthases and nitrotyrosine in systemic sclerosis skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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Matrix Metalloproteinases And Aggrecanase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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inferred from PubMed ID database lookup

Herniation of cervical intervertebral disc: immunohistochemical examination and measurement of nitric oxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/17760968

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inferred from PubMed ID database lookup

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Europe PubMed Central

PMC publication ID

13 August 2017

Dimensions Publication ID

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

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Europe PubMed Central

PMC publication ID

13 August 2017

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