(Q36396899)

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Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure

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scholarly article

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Europe PubMed Central

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13 August 2017

Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure (English)

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Europe PubMed Central

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13 August 2017

Clostridium difficile

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Justin A. MacDonald

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Justin A MacDonald

17

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18

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Paul L Beck

1 reference

Europe PubMed Central

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13 August 2017

author name string

Simon A Hirota

1

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Europe PubMed Central

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13 August 2017

Vadim Iablokov

2

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Europe PubMed Central

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13 August 2017

Sarah E Tulk

3

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Europe PubMed Central

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13 August 2017

L Patrick Schenck

4

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Europe PubMed Central

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13 August 2017

Helen Becker

5

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Europe PubMed Central

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13 August 2017

Jimmie Nguyen

6

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Europe PubMed Central

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13 August 2017

Samir Al Bashir

7

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Europe PubMed Central

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13 August 2017

Tanis C Dingle

8

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Europe PubMed Central

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13 August 2017

Austin Laing

9

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Europe PubMed Central

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13 August 2017

Jianrui Liu

10

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Europe PubMed Central

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13 August 2017

Yan Li

11

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Europe PubMed Central

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13 August 2017

Jeff Bolstad

12

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Europe PubMed Central

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13 August 2017

George L Mulvey

13

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Europe PubMed Central

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13 August 2017

Glen D Armstrong

14

1 reference

Europe PubMed Central

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13 August 2017

Wallace K MacNaughton

15

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13 August 2017

Daniel A Muruve

16

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13 August 2017

language of work or name

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publication date

8 October 2012

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Europe PubMed Central

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13 August 2017

Infection and Immunity

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Europe PubMed Central

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13 August 2017

80

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13 August 2017

12

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13 August 2017

4474-4484

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Europe PubMed Central

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13 August 2017

Induction of cytokines in a macrophage cell line by proteins of Clostridium difficile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Infectious diarrhea: Cellular and molecular mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Clostridium difficile infection: An overview of the disease and its pathogenesis, epidemiology and interventions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Adenosine deaminase inhibition prevents Clostridium difficile toxin A-induced enteritis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Toxin B is essential for virulence of Clostridium difficile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

A mouse model of Clostridium difficile-associated disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Clostridium difficile: changing epidemiology and new treatment options

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Implications of the changing face of Clostridium difficile disease for health care practitioners

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Caspase and bid involvement in Clostridium difficile toxin A-induced apoptosis and modulation of toxin A effects by glutamine and alanyl-glutamine in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Monocytes are highly sensitive to clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Clostridium difficile-associated colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Human intestinal epithelial and smooth muscle cells are potent producers of IL-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Role of inducible cyclooxygenase and prostaglandins in Clostridium difficile toxin A-induced secretion and inflammation in an animal model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Effect of Clostridium difficile toxin A on human colonic lamina propria cells: early loss of macrophages followed by T-cell apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Fecal lactoferrin, interleukin-1beta, and interleukin-8 are elevated in patients with severe Clostridium difficile colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coli in Vibrio cholerae vaccine strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Optimal methods for identifying Clostridium difficile infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Mucosal damage mediated by clostridial toxin in experimental clindamycin-associated colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Effects of Clostridium difficile toxins given intragastrically to animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

30 September 2017

Substance P receptor expression in intestinal epithelium in clostridium difficile toxin A enteritis in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

28 June 2018

IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

28 June 2018

Differential effects of Clostridium difficile toxins A and B on rabbit ileum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

28 June 2018

Association between production of toxins A and B and types of Clostridium difficile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

28 June 2018

Partial Purification and Characterization of a Cytotoxin from Clostridium difficile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

28 June 2018

Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

21 September 2018

Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

21 September 2018

Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497439

21 September 2018

Clostridium difficile-related necrotizing pseudomembranous enteritis in association with Henoch-Schonlein purpura

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of purified Clostridium difficile toxin A on rabbit distal colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridium difficile toxin B disrupts the barrier function of T84 monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous corticosteroids modulate Clostridium difficile toxin A-induced enteritis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Necrotizing enterocolitis during agranulocytosis and Clostridium difficile colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative study of Clostridium difficile toxin A and cholera toxin in rabbit ileum

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An outbreak of Clostridium difficile necrotizing enterocolitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can ischemic colitis be differentiated from C difficile colitis in biopsy specimens?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hapten-induced model of chronic inflammation and ulceration in the rat colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045481

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/IAI.00933-12

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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