(Q36403404)

14 August 2017

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title

Combinatorial roles of nuclear receptors in inflammation and immunity (English)

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14 August 2017

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1

Christopher K Glass

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14 August 2017

Sumito Ogawa

2

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14 August 2017

1 January 2006

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Nature Reviews Immunology

14 August 2017

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14 August 2017

6

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14 August 2017

44-55

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14 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nri1748

14 August 2017

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Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

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Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?

21 January 2018

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The nuclear receptor superfamily: the second decade

21 January 2018

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Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

21 January 2018

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RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

21 January 2018

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The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

21 January 2018

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Determinants of target gene specificity for steroid/thyroid hormone receptors

21 January 2018

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Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

21 January 2018

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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

21 January 2018

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The nuclear receptor ligand-binding domain: structure and function.

21 January 2018

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Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

21 January 2018

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A structural role for hormone in the thyroid hormone receptor.

21 January 2018

1 reference

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

21 January 2018

1 reference

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

21 January 2018

1 reference

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

21 January 2018

1 reference

Structure and specificity of nuclear receptor-coactivator interactions

21 January 2018

1 reference

A transcriptional co-repressor that interacts with nuclear hormone receptors

21 January 2018

1 reference

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

21 January 2018

1 reference

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

21 January 2018

1 reference

Molecular determinants of nuclear receptor-corepressor interaction

21 January 2018

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The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).

21 January 2018

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Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

21 January 2018

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Molecular basis of agonism and antagonism in the oestrogen receptor

21 January 2018

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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

21 January 2018

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Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

21 January 2018

1 reference

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

21 January 2018

1 reference

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

21 January 2018

1 reference

Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

21 January 2018

1 reference

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

21 January 2018

1 reference

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

21 January 2018

1 reference

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

1 reference

Combinatorial control of gene expression by nuclear receptors and coregulators

21 January 2018

1 reference

Coregulator function: a key to understanding tissue specificity of selective receptor modulators

21 January 2018

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Role of protein methylation in regulation of transcription

21 January 2018

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Biological control through regulated transcriptional coactivators

21 January 2018

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Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

21 January 2018

1 reference

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2

21 January 2018

1 reference

Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3

21 January 2018

1 reference

Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1

21 January 2018

1 reference

A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors

21 January 2018

1 reference

Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

21 January 2018

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Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor

21 January 2018

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Retinoic acid is a negative regulator of AP-1-responsive genes.

21 January 2018

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Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

21 January 2018

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Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

21 January 2018

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Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

21 January 2018

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Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

21 January 2018

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A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

21 January 2018

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Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1.

21 January 2018

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Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors

21 January 2018

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The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.

21 January 2018

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Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

21 January 2018

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The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

21 January 2018

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The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression

21 January 2018

1 reference

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

21 January 2018

1 reference

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

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PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages

21 January 2018

1 reference

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

21 January 2018

1 reference

Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor

21 January 2018

1 reference

A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation

21 January 2018

1 reference

SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival

21 January 2018

1 reference

Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA.

21 January 2018

1 reference

Transcriptional repression of atherogenic inflammation: modulation by PPARdelta

21 January 2018

1 reference

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

21 January 2018

1 reference

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

21 January 2018

1 reference

One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers

21 January 2018

1 reference

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

21 January 2018

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DNA binding of the glucocorticoid receptor is not essential for survival

21 January 2018

1 reference

Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation

21 January 2018

1 reference

Glucocorticoid modulation of human monocyte/macrophage function: control of TNF-alpha secretion

21 January 2018

1 reference

Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids.

21 January 2018

1 reference

Glucocorticoid-induced reduction of prostanoid synthesis in TPA-differentiated U937 cells is mainly due to a reduced cyclooxygenase activity

21 January 2018

1 reference

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

21 January 2018

1 reference

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

21 January 2018

1 reference

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

21 January 2018

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PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

21 January 2018

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Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages

21 January 2018

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Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent

21 January 2018

1 reference

Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors

21 January 2018

1 reference

Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis

21 January 2018

1 reference

Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells

21 January 2018

1 reference

Peroxisome proliferator-activated receptor γ activators inhibit interleukin-12 production in murine dendritic cells

21 January 2018

1 reference

Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway

21 January 2018

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Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction

21 January 2018

1 reference

PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells

21 January 2018

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The PPARalpha-leukotriene B4 pathway to inflammation control.

21 January 2018

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Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators.

21 January 2018

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PPARs in atherosclerosis: the clot thickens

21 January 2018

1 reference

Nuclear receptor signaling in macrophages.

21 January 2018

1 reference

Emerging roles of PPARs in inflammation and immunity

21 January 2018

1 reference

PPARs as drug targets to modulate inflammatory responses?

21 January 2018

1 reference

15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

21 January 2018

1 reference

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

21 January 2018

1 reference

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

21 January 2018

1 reference

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

21 January 2018

1 reference

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

21 January 2018

1 reference

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

21 January 2018

1 reference

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

21 January 2018

1 reference

Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

21 January 2018

1 reference

LXR-dependent gene expression is important for macrophage survival and the innate immune response

21 January 2018

1 reference

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

21 January 2018

1 reference

Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.

21 January 2018

1 reference

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

21 January 2018

1 reference

Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice

21 January 2018

1 reference

Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma

21 January 2018

1 reference

Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice

21 January 2018

1 reference

Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies

21 January 2018

1 reference

A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response

21 January 2018

1 reference

Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis

21 January 2018

1 reference

Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation

21 January 2018

1 reference

Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression

21 January 2018

1 reference

A Nuclear Receptor Atlas: macrophage activation

21 January 2018

1 reference

Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product

21 January 2018

1 reference

The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses

21 January 2018

1 reference

Activation of PPARγ Specifies a Dendritic Cell Subtype Capable of Enhanced Induction of iNKT Cell Expansion

31 March 2020

1 reference

The LXRs: a new class of oxysterol receptors

31 March 2020

1 reference

Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis

31 March 2020

1 reference

What happened to drug trials in ulcerative colitis? Problems, PPARs, placebos, and (possible) progress

31 March 2020

1 reference

Regulation of cytokine and cytokine receptor expression by glucocorticoids

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1748

1 reference

PubMed ID

16493426

Dimensions Publication ID

14 August 2017

0 references

1 reference

PubMed ID

16493426