(Q36407908)

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Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular endothelial growth factor (VEGF) expression in non-small cell lung cancer.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992725%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular endothelial growth factor (VEGF) expression in non-small cell lung cancer (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992725%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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5

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13 February 2020

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Karl Deacon

1

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13 February 2020

David Onion

2

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13 February 2020

Rajendra Kumari

3

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13 February 2020

Susan A Watson

4

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13 February 2020

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18 September 2012

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13 February 2020

Journal of Biological Chemistry

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13 February 2020

287

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13 February 2020

47

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13 February 2020

39967-39981

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992725%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Sp1 is upregulated in human glioma, promotes MMP-2-mediated cell invasion and predicts poor clinical outcome

1 reference

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30 September 2017

Hypoxia in models of lung cancer: implications for targeted therapeutics

1 reference

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The role of Sp1 and Sp3 in normal and cancer cell biology

1 reference

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30 September 2017

Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells

1 reference

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30 September 2017

EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth

1 reference

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30 September 2017

Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501049

30 September 2017

Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action

1 reference

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1 reference

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30 September 2017

Sp1: emerging roles--beyond constitutive activation of TATA-less housekeeping genes

1 reference

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30 September 2017

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation

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The role of the EGFR signaling in tumor microenvironment.

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30 September 2017

Alternative splicing in angiogenesis: the vascular endothelial growth factor paradigm

1 reference

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Vascular endothelial growth factor promoter-based conditionally replicative adenoviruses for pan-carcinoma application

1 reference

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30 September 2017

Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.

1 reference

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30 September 2017

Down-regulation of overexpressed sp1 protein in human fibrosarcoma cell lines inhibits tumor formation.

1 reference

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30 September 2017

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1 reference

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30 September 2017

Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion.

1 reference

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30 September 2017

Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501049

30 September 2017

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

1 reference

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30 September 2017

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501049

30 September 2017

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501049

30 September 2017

The contributions of cyclooxygenase-2 to tumor angiogenesis

1 reference

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Oncogenes and angiogenesis: signaling three-dimensional tumor growth

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30 September 2017

Respiratory syncytial virus stimulation of vascular endothelial cell growth Factor/Vascular permeability factor

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30 September 2017

Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501049

30 September 2017

Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma.

1 reference

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30 September 2017

The Hallmarks of Cancer

1 reference

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30 September 2017

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

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30 September 2017

Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo

1 reference

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30 September 2017

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

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30 September 2017

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

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30 September 2017

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1 reference

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Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo

1 reference

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Post-transcriptional regulation of vascular endothelial growth factor: implications for tumor angiogenesis

1 reference

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28 June 2018

Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element

1 reference

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28 June 2018

Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501049

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Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3501049

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Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF.

1 reference

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c-Jun and JunB are essential for hypoglycemia-mediated VEGF induction.

1 reference

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HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

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1 reference

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Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites.

1 reference

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Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway

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Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.397042

21 January 2018

Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer

1 reference

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Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-Flt1 and VEGF-R2-Flk1/KDR) in non-small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/22992725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth and metastasis of tumor in organ culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22992725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet-derived growth factor induces tissue factor expression in vascular smooth muscle cells via activation of Egr-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22992725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of total VEGF mRNA and protein expression with histologic type, tumor angiogenesis, patient survival and timing of relapse in non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22992725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenesis and a poor prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22992725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22992725

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.397042

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992725%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992725%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22992725%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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