(Q36411463)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

0 references

1 reference

spike glycoprotein [SARS-Cov]

0 references

author

Markus Hoffmann

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Stefan Pöhlmann

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

author name string

Lennart Michel Reinke

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Martin Spiegel

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Teresa Plegge

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Anika Hartleib

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Inga Nehlmeier

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Stefanie Gierer

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Heike Hofmann-Winkler

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Michael Winkler

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

language of work or name

English

0 references

publication date

21 June 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

page(s)

e0179177

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

23 March 2020

copyright license

start time

21 June 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.

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30 September 2017

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Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

30 September 2017

1 reference

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IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms

30 September 2017

1 reference

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The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses

30 September 2017

1 reference

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TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice

30 September 2017

1 reference

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Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.

30 September 2017

1 reference

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Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.

30 September 2017

1 reference

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From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses

30 September 2017

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Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

30 September 2017

1 reference

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Mechanisms of coronavirus cell entry mediated by the viral spike protein

30 September 2017

1 reference

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Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5479546

Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5479546

Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5479546

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5479546

Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5479546

Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5479546

Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5479546

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

30 September 2017

1 reference

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Insights from the association of SARS-CoV S-protein with its receptor, ACE2.

30 September 2017

1 reference

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The coxsackievirus 2B protein increases efflux of ions from the endoplasmic reticulum and Golgi, thereby inhibiting protein trafficking through the Golgi

30 September 2017

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Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

30 September 2017

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30 September 2017

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30 September 2017

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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide

28 June 2018

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28 June 2018

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21 September 2018

1 reference

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Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell-cell fusion but does not affect virion entry.

21 September 2018

1 reference

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10.1371/JOURNAL.PONE.0179177

21 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28636671%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference