(Q36414239)

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Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer

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scholarly article

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Europe PubMed Central

14 August 2017

Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer (English)

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Europe PubMed Central

14 August 2017

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Fred R Hirsch

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Europe PubMed Central

14 August 2017

author name string

Ningning Cheng

1

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Europe PubMed Central

14 August 2017

Weijing Cai

2

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Europe PubMed Central

14 August 2017

Shengxiang Ren

3

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Europe PubMed Central

14 August 2017

Xuefei Li

4

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Europe PubMed Central

14 August 2017

Qi Wang

5

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Europe PubMed Central

14 August 2017

Hui Pan

6

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Europe PubMed Central

14 August 2017

Mingchuan Zhao

7

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Europe PubMed Central

14 August 2017

Jiayu Li

8

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Europe PubMed Central

14 August 2017

Yishi Zhang

9

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Europe PubMed Central

14 August 2017

Chao Zhao

10

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Europe PubMed Central

14 August 2017

Xiaoxia Chen

11

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Europe PubMed Central

14 August 2017

Ke Fei

12

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14 August 2017

Caicun Zhou

13

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14 August 2017

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publication date

8 June 2015

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14 August 2017

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Europe PubMed Central

14 August 2017

6

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14 August 2017

27

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14 August 2017

23582-23593

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Europe PubMed Central

14 August 2017

Epidermal growth factor receptor (EGFR) mutations are exceptionally rare in thyroid transcription factor (TTF-1)-negative adenocarcinomas of the lung.

1 reference

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30 September 2017

Pathways driving the endocytosis of mutant and wild-type EGFR in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

Microarray expression profile of long non-coding RNAs in EGFR-TKIs resistance of human non-small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: comparative pharmacokinetics and drug-drug interactions

1 reference

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30 September 2017

Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors.

1 reference

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30 September 2017

Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer

1 reference

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30 September 2017

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

1 reference

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30 September 2017

Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway

1 reference

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30 September 2017

Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer

1 reference

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30 September 2017

Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling

1 reference

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30 September 2017

Novel agents and strategies for overcoming EGFR TKIs resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

MiR-21 overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer

1 reference

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30 September 2017

The epigenetics of epithelial-mesenchymal plasticity in cancer

1 reference

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30 September 2017

Emerging paradigms in the development of resistance to tyrosine kinase inhibitors in lung cancer

1 reference

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30 September 2017

Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells

1 reference

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30 September 2017

The roles of LSD1-mediated epigenetic modifications in maintaining the pluripotency of bladder cancer stem cells

1 reference

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30 September 2017

Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer

1 reference

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30 September 2017

The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell

1 reference

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30 September 2017

Long noncoding RNAs and the genetics of cancer.

1 reference

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30 September 2017

Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

Nodal promotes invasive phenotypes via a mitogen-activated protein kinase-dependent pathway

1 reference

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30 September 2017

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

1 reference

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30 September 2017

Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

MicroRNA-214 regulates the acquired resistance to gefitinib via the PTEN/AKT pathway in EGFR-mutant cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

Overcoming molecular mechanisms of resistance to first-generation epidermal growth factor receptor tyrosine kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

Non-coding RNAs in human disease

1 reference

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30 September 2017

EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study

1 reference

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30 September 2017

Blocking the PI3K/AKT and MEK/ERK signaling pathways can overcome gefitinib-resistance in non-small cell lung cancer cell lines

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30 September 2017

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study

1 reference

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30 September 2017

American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay

1 reference

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30 September 2017

Integrin beta1 over-expression associates with resistance to tyrosine kinase inhibitor gefitinib in non-small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4695138

30 September 2017

Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

1 reference

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30 September 2017

Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome

1 reference

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30 September 2017

UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion

1 reference

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30 September 2017

Non-coding RNAs, epigenetics and complexity

1 reference

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30 September 2017

Perceptions of epigenetics

1 reference

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30 September 2017

Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR.

1 reference

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Riboregulator H19 induction of MDR1-associated drug resistance in human hepatocellular carcinoma cells

1 reference

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30 September 2017

Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

1 reference

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30 September 2017

Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer

1 reference

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28 June 2018

Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma

1 reference

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21 September 2018

Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells.

1 reference

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21 September 2018

Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib

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21 September 2018

Identifiers

10.18632/ONCOTARGET.4361

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1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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