(Q36416387)

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Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model

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Europe PubMed Central

PMC publication ID

14 August 2017

Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

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Michael Lim

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Europe PubMed Central

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14 August 2017

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Dimitrios Mathios

1

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Europe PubMed Central

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14 August 2017

Chul-Kee Park

2

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Europe PubMed Central

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14 August 2017

Warren D Marcus

3

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Europe PubMed Central

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14 August 2017

Sarah Alter

4

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Europe PubMed Central

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14 August 2017

Peter R Rhode

5

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Europe PubMed Central

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14 August 2017

Emily K Jeng

6

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Europe PubMed Central

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14 August 2017

Hing C Wong

7

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14 August 2017

Drew M Pardoll

8

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14 August 2017

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publication date

14 July 2015

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14 August 2017

International Journal of Cancer

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14 August 2017

138

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Europe PubMed Central

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14 August 2017

1

1 reference

Europe PubMed Central

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14 August 2017

187-194

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Europe PubMed Central

PMC publication ID

14 August 2017

Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice

1 reference

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30 September 2017

Increasing glioma-associated monocytes leads to increased intratumoral and systemic myeloid-derived suppressor cells in a murine model

1 reference

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30 September 2017

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

1 reference

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30 September 2017

Enhanced immunosuppression by therapy-exposed glioblastoma multiforme tumor cells

1 reference

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30 September 2017

CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.

1 reference

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30 September 2017

Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model

1 reference

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30 September 2017

Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors

1 reference

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30 September 2017

Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced bladder cancer rat model; a role for cytokine production and NK cell expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4696021

30 September 2017

The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity

1 reference

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30 September 2017

Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor αSu/Fc fusion complex in syngeneic murine models of multiple myeloma

1 reference

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30 September 2017

Gliomas promote immunosuppression through induction of B7-H1 expression in tumor-associated macrophages

1 reference

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30 September 2017

Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas

1 reference

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30 September 2017

Immunology beats cancer: a blueprint for successful translation

1 reference

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30 September 2017

The blockade of immune checkpoints in cancer immunotherapy

1 reference

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30 September 2017

Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide

1 reference

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30 September 2017

Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

1 reference

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30 September 2017

Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy

1 reference

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Cure of established GL261 mouse gliomas after combined immunotherapy with GM-CSF and IFNgamma is mediated by both CD8+ and CD4+ T-cells

1 reference

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30 September 2017

Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells

1 reference

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30 September 2017

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

1 reference

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30 September 2017

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

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30 September 2017

Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4696021

30 September 2017

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4696021

30 September 2017

Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4696021

30 September 2017

Interleukin-2 and lymphokine activated killer (LAK) cells in the treatment of malignant glioma: clinical and experimental studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4696021

28 June 2018

Activated endothelial cells resist lymphokine-activated killer cell-mediated injury. Possible role of induced cytokines in limiting capillary leak during IL-2 therapy.

1 reference

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28 June 2018

Intralesional lymphokine-activated killer cells as adjuvant therapy for primary glioblastoma

1 reference

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Intracerebral interleukin 12 induces glioma rejection in the brain predominantly by CD8+ T cells and independently of interferon-gamma

1 reference

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Cutting Edge: IL-10-producing CD4+ T cells mediate tumor rejection.

1 reference

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21 September 2018

Identifiers

10.1002/IJC.29686

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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