(Q36417755)

14 August 2017

1 reference

title

TIR, CARD and PYRIN: three domains for an antimicrobial triad (English)

1 reference

14 August 2017

C Werts

1

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14 August 2017

S E Girardin

series ordinal

2

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14 August 2017

D J Philpott

series ordinal

3

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14 August 2017

publication date

1 May 2006

1 reference

Cell Death & Differentiation

14 August 2017

published in

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14 August 2017

volume

13

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14 August 2017

issue

5

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14 August 2017

page(s)

798-815

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401890

14 August 2017

exact match

0 references

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21 January 2018

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Direct evidence that toll-like receptor 9 (TLR9) functionally binds plasmid DNA by specific cytosine-phosphate-guanine motif recognition.

21 January 2018

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21 January 2018

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Regulation of lung injury and repair by Toll-like receptors and hyaluronan

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

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Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

21 January 2018

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mRNA is an endogenous ligand for Toll-like receptor 3.

21 January 2018

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

21 January 2018

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

21 January 2018

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Evasion of Toll-like receptor 5 by flagellated bacteria

21 January 2018

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TLR11 activation of dendritic cells by a protozoan profilin-like protein.

21 January 2018

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A toll-like receptor that prevents infection by uropathogenic bacteria

21 January 2018

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Inherited disorders of human Toll-like receptor signaling: immunological implications.

21 January 2018

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IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism

21 January 2018

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TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway

21 January 2018

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IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Negative regulation of toll-like receptor-mediated immune responses

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Negative regulation of Toll-like-receptor signaling by IRF-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Viral appropriation of apoptotic and NF-kappaB signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

NACHT-LRR proteins (NLRs) in bacterial infection and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Staphylococcus aureus peptidoglycan is a toll-like receptor 2 activator: a reevaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Synthesis of peptidoglycan fragments and evaluation of their biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The role of peptidoglycan in pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Identification of the critical residues involved in peptidoglycan detection by Nod1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nod1 Participates in the Innate Immune Response toPseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Cell type-specific involvement of RIG-I in antiviral response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Evasion of intracellular host defence by hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Reciprocal cross-talk between Nod2 and TAK1 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

VISA is an adapter protein required for virus-triggered IFN-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

A FADD-dependent innate immune mechanism in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

CARD15 mutations in Blau syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

NOD1 variation, immunoglobulin E and asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Association of NOD1 polymorphisms with atopic eczema and related phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

CARD4/NOD1 is not involved in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

NALPs: a novel protein family involved in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

A new CARD15 mutation in Blau syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Cryopyrin activates the inflammasome in response to toxins and ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Gout-associated uric acid crystals activate the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Synergistic enhancement of Toll-like receptor responses by NOD1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

Unresponsiveness of MyD88-deficient mice to endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

7 January 2021

Endotoxin-induced maturation of MyD88-deficient dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

7 January 2021

NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

7 January 2021

Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

7 January 2021

Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

7 January 2021

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

7 January 2021

Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401890

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401890

1 reference

14 August 2017

1 reference