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Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
review article
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stated in
Europe PubMed Central
title
Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
main subject
endoplasmic reticulum
0 references
protein folding
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author
David Ron
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
Heather P Harding
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Heather P Harding
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2
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publication date
1 December 2012
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Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
published in
Cold Spring Harbor Perspectives in Biology
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stated in
Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
volume
4
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stated in
Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
issue
12
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Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
cites work
Protein folding in the endoplasmic reticulum
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30 September 2017
Endoplasmic reticulum stress sensing in the unfolded protein response
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30 September 2017
The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi
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30 September 2017
Protein translocation across the rough endoplasmic reticulum
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PubMed Central
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30 September 2017
The mammalian endoplasmic reticulum-associated degradation system
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30 September 2017
Disulfide bond formation in the mammalian endoplasmic reticulum
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Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis
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Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes
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30 September 2017
Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism
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Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
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30 September 2017
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion
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Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
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Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
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30 September 2017
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction
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30 September 2017
Wolcott-Rallison syndrome
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30 September 2017
PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway
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30 September 2017
ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis
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30 September 2017
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective
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30 September 2017
Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation
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30 September 2017
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
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30 September 2017
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
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30 September 2017
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development
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30 September 2017
Divergent effects of PERK and IRE1 signaling on cell viability
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30 September 2017
Rationalizing translation attenuation in the network architecture of the unfolded protein response.
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30 September 2017
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
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30 September 2017
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
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30 September 2017
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
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30 September 2017
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
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30 September 2017
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice
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30 September 2017
Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus
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30 September 2017
Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function
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PubMed Central
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30 September 2017
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
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30 September 2017
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis
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30 September 2017
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.
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30 September 2017
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
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30 September 2017
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.
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30 September 2017
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
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30 September 2017
Dynamic cycling of eIF2 through a large eIF2B-containing cytoplasmic body: implications for translation control
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30 September 2017
ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity
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30 September 2017
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
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30 September 2017
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
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30 September 2017
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
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30 September 2017
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
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30 September 2017
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
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30 September 2017
Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and a
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30 September 2017
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
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30 September 2017
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells
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30 September 2017
Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.
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30 September 2017
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
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30 September 2017
Stress-induced gene expression requires programmed recovery from translational repression
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30 September 2017
Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2
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30 September 2017
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
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PubMed Central
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30 September 2017
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
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PubMed Central
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30 September 2017
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
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30 September 2017
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
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30 September 2017
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
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30 September 2017
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
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30 September 2017
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
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30 September 2017
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
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30 September 2017
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
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30 September 2017
Regulated translation initiation controls stress-induced gene expression in mammalian cells
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30 September 2017
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome
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PubMed Central
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30 September 2017
Perk is essential for translational regulation and cell survival during the unfolded protein response
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30 September 2017
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
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30 September 2017
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
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30 September 2017
A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse
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30 September 2017
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
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30 September 2017
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
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PubMed Central
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30 September 2017
Phenotypic alterations in insulin-deficient mutant mice.
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30 September 2017
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
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30 September 2017
Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153).
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30 September 2017
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
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30 September 2017
Persisting Enhanced Proinsulin-insulin and Protein Biosynthesis (3H-Leucine Incorporation) by Pancreatic Islets of the Rat after Glucose Exposure
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30 September 2017
Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions
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28 June 2018
Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504434
retrieved
28 June 2018
Endoplasmic reticulum stress plays a central role in development of leptin resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504434
retrieved
21 September 2018
Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504434
retrieved
21 September 2018
Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504434
retrieved
21 September 2018
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23209157
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/CSHPERSPECT.A013177
1 reference
stated in
Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
PMCID
3504434
1 reference
stated in
Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
PubMed ID
23209157
1 reference
stated in
Europe PubMed Central
PMCID
3504434
retrieved
14 August 2017
ResearchGate publication ID
233840275
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