(Q36418792)

English

Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).

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13 February 2020

Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) (English)

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13 February 2020

Sergei Y Noskov

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13 February 2020

Aldo A Rodríguez-Menchaca

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13 February 2020

Vasileios I Petrou

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13 February 2020

Diomedes E Logothetis

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Diomedes E Logothetis

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13 February 2020

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Irena Levitan

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13 February 2020

Avia Rosenhouse-Dantsker

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13 February 2020

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Scott K Adney

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13 February 2020

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Huazhi Han

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13 February 2020

Qiong-Yao Tang

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13 February 2020

Gregory B Kowalsky

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13 February 2020

Catherine V Osborn

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13 February 2020

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20 September 2012

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13 February 2020

Journal of Biological Chemistry

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13 February 2020

287

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13 February 2020

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13 February 2020

40266-40278

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13 February 2020

Regulation of ion channels by membrane lipids

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30 September 2017

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

1 reference

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30 September 2017

Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol.

1 reference

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30 September 2017

Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore

1 reference

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30 September 2017

NMR analyses of the Gbetagamma binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (GIRK1).

1 reference

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30 September 2017

Cholesterol and ion channels

1 reference

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30 September 2017

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution

1 reference

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30 September 2017

Direct regulation of prokaryotic Kir channel by cholesterol

1 reference

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30 September 2017

CHARMM-GUI Membrane Builder for mixed bilayers and its application to yeast membranes

1 reference

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30 September 2017

Cholesterol and Kir channels

1 reference

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30 September 2017

CHARMM: the biomolecular simulation program

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30 September 2017

Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504743

30 September 2017

Crystal structure of a Kir3.1-prokaryotic Kir channel chimera

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504743

30 September 2017

Molecular characteristics of phosphoinositide binding

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504743

30 September 2017

Phosphoinositide-mediated gating of inwardly rectifying K(+) channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504743

30 September 2017

Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies

1 reference

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30 September 2017

New roles for a key glycine and its neighboring residue in potassium channel gating

1 reference

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30 September 2017

Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504743

30 September 2017

Scalable molecular dynamics with NAMD

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30 September 2017

Caveolin-1 expression and membrane cholesterol content modulate N-type calcium channel activity in NG108-15 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504743

30 September 2017

Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504743

30 September 2017

Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands.

1 reference

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30 September 2017

Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels

1 reference

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30 September 2017

Cellular domains that contribute to Ca2+ entry events

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30 September 2017

Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol

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30 September 2017

Rectifying Properties of Heart Muscle

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30 September 2017

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21 January 2018

Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol

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30 September 2017

Phosphoinositide regulation of the actin cytoskeleton

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30 September 2017

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504743

30 September 2017

Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins

1 reference

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30 September 2017

The complex and intriguing lives of PIP2 with ion channels and transporters

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30 September 2017

Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504743

30 September 2017

Membrane cholesterol content modulates activation of volume-regulated anion current in bovine endothelial cells

1 reference

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30 September 2017

VMD: visual molecular dynamics

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30 September 2017

Satisfying hydrogen bonding potential in proteins

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30 September 2017

Cholesterol regulates prokaryotic Kir channel by direct binding to channel protein

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Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop

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28 June 2018

A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2).

1 reference

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28 June 2018

Sensitivity of volume-regulated anion current to cholesterol structural analogues

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Probing the effects of membrane cholesterol in the Torpedo californica acetylcholine receptor and the novel lipid-exposed mutation alpha C418W in Xenopus oocytes

1 reference

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28 June 2018

Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation.

1 reference

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28 June 2018

A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels

1 reference

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28 June 2018

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma

1 reference

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28 June 2018

Variations of membrane cholesterol alter the kinetics of Ca2(+)-dependent K+ channels and membrane fluidity in vascular smooth muscle cells

1 reference

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28 June 2018

Haemodynamic shear stress activates a K+ current in vascular endothelial cells.

1 reference

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28 June 2018

Hypercholesterolemia abolishes voltage-dependent K+ channel contribution to adenosine-mediated relaxation in porcine coronary arterioles.

1 reference

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21 January 2018

Isoform-specific localization of voltage-gated K+ channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae

1 reference

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21 January 2018

Hypercholesterolemia inhibits L-type calcium current in coronary macro-, not microcirculation.

1 reference

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21 January 2018

Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains.

1 reference

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21 January 2018

Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification

1 reference

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21 January 2018

Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.336339

21 January 2018

Ion-blocking sites of the Kir2.1 channel revealed by multiscale modeling.

1 reference

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21 January 2018

Comparison of simple potential functions for simulating liquid water

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.336339

21 January 2018

Relationship between Kir2.1/Kir2.3 activity and their distributions between cholesterol-rich and cholesterol-poor membrane domains.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.336339

21 January 2018

Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.336339

21 January 2018

Differential Targeting of Shaker-like Potassium Channels to Lipid Rafts

1 reference

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21 January 2018

The effect of hypercholesterolemia on the sodium inward currents in cardiac myocyte

1 reference

https://pubmed.ncbi.nlm.nih.gov/22995912

12 December 2020

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inferred from PubMed ID database lookup

Membrane stiffness and channel function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22995912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.336339

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22995912%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22995912%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22995912%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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