(Q36419224)

14 August 2017

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title

The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease (English)

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14 August 2017

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V H Haase

1

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PubMed ID

16531988

14 August 2017

language of work or name

English

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publication date

1 April 2006

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14 August 2017

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14 August 2017

69

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14 August 2017

1302-1307

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14 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/sj.ki.5000221

14 August 2017

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cites work

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Regulation of angiogenesis by hypoxia: role of the HIF system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Hypoxic induction of Ctgf is directly mediated by Hif-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

von Hippel-Lindau disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Glomerular inflammation induces resistance to tubular injury in the rat. A novel form of acquired, heme oxygenase-dependent resistance to renal injury

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Prior induction of heme oxygenase-1 with glutathione depletor ameliorates the renal ischemia and reperfusion injury in the rat.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Erythropoietin protects against ischaemic acute renal injury

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Hypoxia stimulates proximal tubular cell matrix production via a TGF-beta1-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

A cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-beta1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Alteration of type I and III collagen expression in human peritoneal mesothelial cells in response to hypoxia and transforming growth factor-beta1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Hypoxia promotes fibrogenesis in human renal fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Cellular response to hypoxia involves signaling via Smad proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Transdifferentiation of cultured tubular cells induced by hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Epithelial-mesenchymal transition and its implications for fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Hypoxia requires notch signaling to maintain the undifferentiated cell state

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.KI.5000221

7 January 2021

Identifiers

DOI

10.1038/SJ.KI.5000221

1 reference

PubMed ID

16531988

Dimensions Publication ID

14 August 2017

0 references

1 reference

PubMed ID

16531988