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Cellular response to hypoxia involves signaling via Smad proteins
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title
Cellular response to hypoxia involves signaling via Smad proteins
(English)
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main subject
hypoxia
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SMAD family member 3
1 reference
stated in
GOA release 2020-03-11
SMAD family member 4
1 reference
stated in
GOA release 2020-03-11
Hypoxia inducible factor 1 subunit alpha
1 reference
stated in
GOA release 2020-03-11
Transforming growth factor beta 2
1 reference
stated in
GOA release 2020-03-11
SMAD family member 2
1 reference
stated in
GOA release 2020-03-11
regulation of transforming growth factor beta2 production
1 reference
stated in
GOA release 2020-03-11
author name string
Hong Zhang
series ordinal
1
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Hasan O Akman
series ordinal
2
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Eric L P Smith
series ordinal
3
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Jin Zhao
series ordinal
4
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Joanne E Murphy-Ullrich
series ordinal
5
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Olcay A Batuman
series ordinal
6
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language of work or name
English
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publication date
15 March 2003
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published in
Blood
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volume
101
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issue
6
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page(s)
2253-60
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cites work
An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
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TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
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Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
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Hypoxia-regulated gene expression in fetal wound regeneration and adult wound repair
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
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Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors
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Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells
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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
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Thrombospondin-1 is a major activator of TGF-beta1 in vivo
1 reference
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Crossref
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Smads: transcriptional activators of TGF-beta responses
1 reference
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Crossref
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The functions of thrombospondin-1 and-2.
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Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
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Ubiquitin-dependent degradation of TGF-beta-activated smad2.
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Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
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Latent transforming growth factor-beta: structural features and mechanisms of activation
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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL
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Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
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Transforming growth factor beta2 inhibition of hepatocyte growth factor-induced endothelial proliferation and migration
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Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.
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Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
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7 January 2021
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Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
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7 January 2021
based on heuristic
inferred from DOI database lookup
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
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7 January 2021
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Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1.
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Crossref
reference URL
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7 January 2021
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Purification and characterization of hypoxia-inducible factor 1
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Crossref
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7 January 2021
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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
1 reference
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Crossref
reference URL
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7 January 2021
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Physical and functional interaction of SMADs and p300/CBP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
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7 January 2021
based on heuristic
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MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
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7 January 2021
based on heuristic
inferred from DOI database lookup
The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
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7 January 2021
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inferred from DOI database lookup
Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
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inferred from DOI database lookup
Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
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inferred from DOI database lookup
Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
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inferred from DOI database lookup
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
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inferred from DOI database lookup
Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
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inferred from DOI database lookup
Detecting and responding to hypoxia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
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inferred from DOI database lookup
Antiangiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective angiogenesis in mice lacking endoglin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGF-beta signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A murine model of hereditary hemorrhagic telangiectasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Response to hypoxia involves transforming growth factor-beta2 and Smad proteins in human endothelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2002-02-0629
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1182/BLOOD-2002-02-0629
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4745089
OpenCitations bibliographic resource ID
4745089
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4745089
PubMed publication ID
12411310
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4745089
ResearchGate publication ID
11054272
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