(Q36419233)

14 August 2017

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title

Lipid II as a target for antibiotics (English)

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14 August 2017

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ChEBI release 2020-05-28

1

Eefjan Breukink

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14 August 2017

2

Ben de Kruijff

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14 August 2017

1 April 2006

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Nature Reviews Drug Discovery

14 August 2017

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14 August 2017

5

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14 August 2017

321-332

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14 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrd2004

14 August 2017

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cites work

Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus

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Isolation and separation of the glycan strands from murein of Escherichia coli by reversed-phase high-performance liquid chromatography

21 January 2018

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Resistance of Gram-positive bacteria to nisin is not determined by lipid II levels

21 January 2018

1 reference

Biosynthesis and mode of action of lantibiotics.

21 January 2018

1 reference

Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis

21 January 2018

1 reference

Applications of the bacteriocin, nisin

21 January 2018

1 reference

Mode of action of the peptide antibiotic nisin and influence on the membrane potential of whole cells and on cytoplasmic and artificial membrane vesicles

21 January 2018

1 reference

In vitro pore-forming activity of the lantibiotic nisin. Role of protonmotive force and lipid composition.

21 January 2018

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Interaction of the lantibiotic nisin with membranes revealed by fluorescence quenching of an introduced tryptophan.

21 January 2018

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Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics

21 January 2018

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Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic.

21 January 2018

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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?

21 January 2018

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Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity

21 January 2018

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The orientation of nisin in membranes.

21 January 2018

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Voltage-dependent depolarization of bacterial membranes and artificial lipid bilayers by the peptide antibiotic nisin

21 January 2018

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Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin

21 January 2018

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Lipid II-mediated pore formation by the peptide antibiotic nisin: a black lipid membrane study

21 January 2018

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Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes

21 January 2018

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Targeting extracellular pyrophosphates underpins the high selectivity of nisin

21 January 2018

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Assembly and stability of nisin-lipid II pores

21 January 2018

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The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics

21 January 2018

1 reference

Genetics and mechanisms of glycopeptide resistance in enterococci

21 January 2018

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NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity

21 January 2018

1 reference

Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity.

21 January 2018

1 reference

Chemistry and biology of the ramoplanin family of peptide antibiotics

21 January 2018

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Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity

21 January 2018

1 reference

Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation

21 January 2018

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Total synthesis and examination of three key analogues of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity

21 January 2018

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Total synthesis of the ramoplanin A2 and ramoplanose aglycon

21 January 2018

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Rethinking ramoplanin: the role of substrate binding in inhibition of peptidoglycan biosynthesis.

21 January 2018

1 reference

Functional analysis of the lipoglycodepsipeptide antibiotic ramoplanin

21 January 2018

1 reference

A novel main-chain anion-binding site in proteins: the nest. A particular combination of phi,psi values in successive residues gives rise to anion-binding sites that occur commonly and are found often at functionally important regions

21 January 2018

1 reference

The conformations of polypeptide chains where the main-chain parts of successive residues are enantiomeric. Their occurrence in cation and anion-binding regions of proteins

21 January 2018

1 reference

Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98: antibacterial and mechanistic activities.

21 January 2018

1 reference

Mannopeptimycins, novel antibacterial glycopeptides from Streptomyces hygroscopicus, LL-AC98.

21 January 2018

1 reference

Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria

21 January 2018

1 reference

Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria

21 January 2018

1 reference

Isolation and characterization of katanosins A and B

21 January 2018

1 reference

Katanosin B and plusbacin A(3), inhibitors of peptidoglycan synthesis in methicillin-resistant Staphylococcus aureus

21 January 2018

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Resistance to nisin and production of nisin-inactivating enzymes by several Bacillus species.

21 January 2018

1 reference

Nisin resistance of Streptococcus bovis

21 January 2018

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Antibacterial efficacy of nisin against multidrug-resistant Gram- positive pathogens

21 January 2018

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A continuum of anionic charge: structures and functions of D-alanyl-teichoic acids in gram-positive bacteria

21 January 2018

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The Bacillus subtilis extracytoplasmic-function sigmaX factor regulates modification of the cell envelope and resistance to cationic antimicrobial peptides.

21 January 2018

1 reference

Ramoplanin: a lipoglycodepsipeptide antibiotic

21 January 2018

1 reference

Nisin, alone and combined with peptidoglycan-modulating antibiotics: activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci

21 January 2018

1 reference

Nisin in experimental tuberculosis.

21 January 2018

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MICs of mutacin B-Ny266, nisin A, vancomycin, and oxacillin against bacterial pathogens

21 January 2018

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Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides

21 January 2018

1 reference

Site-directed mutagenesis of the hinge region of nisinZ and properties of nisinZ mutants

21 January 2018

1 reference

Mannopeptimycins, a novel class of glycopeptide antibiotics active against gram-positive bacteria

21 January 2018

1 reference

Differential release of lipoteichoic and teichoic acids from Streptococcus pneumoniae as a result of exposure to beta-lactam antibiotics, rifamycins, trovafloxacin, and quinupristin-dalfopristin

21 January 2018

1 reference

Mersacidin eradicates methicillin-resistant Staphylococcus aureus (MRSA) in a mouse rhinitis model.

21 January 2018

1 reference

In vivo efficacy and pharmacokinetics of AC98-6446, a novel cyclic glycopeptide, in experimental infection models

21 January 2018

1 reference

Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine

21 January 2018

1 reference

LIPID-PHOSPHOACETYLMURAMYL-PENTAPEPTIDE AND LIPID-PHOSPHODISACCHARIDE-PENTAPEPTIDE: PRESUMED MEMBRANE TRANSPORT INTERMEDIATES IN CELL WALL SYNTHESIS

21 January 2018

1 reference

Specificity of combination between mucopeptide precursors and vancomycin or ristocetin

21 January 2018

1 reference

Iodinated vancomycin and mucopeptide biosynthesis by cell-free preparations from Micrococcus lysodeikticus

21 January 2018

1 reference

Structure of vancomycin and a vancomycin/D-Ala-D-Ala complex in solution

21 January 2018

1 reference

Getting closer to the real bacterial cell wall target: biomolecular interactions of water-soluble lipid II with glycopeptide antibiotics

21 January 2018

1 reference

Origin, structure, and activity in vitro and in vivo of dalbavancin

21 January 2018

1 reference

Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus

21 January 2018

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Oritavancin: a new avenue for resistant Gram-positive bacteria

21 January 2018

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In vitro activity of mersacidin (M87-1551), an investigational peptide antibiotic tested against gram-positive bloodstream isolates

21 January 2018

1 reference

Comparative in vitro activities of AC98-6446, a novel semisynthetic glycopeptide derivative of the natural product mannopeptimycin alpha, and other antimicrobial agents against gram-positive clinical isolates

21 January 2018

1 reference

Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin

21 January 2018

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Paramagnetic isoprenoid carrier lipids. 2. Dispersion and dynamics in lipid membranes

21 January 2018

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The effect of nisin on murein synthesis

31 March 2020

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The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane

31 March 2020

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Binding of Nisin Z to bilayer vesicles as determined with isothermal titration calorimetry

31 March 2020

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Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore

31 March 2020

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Pore formation by nisin involves translocation of its C-terminal part across the membrane

31 March 2020

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The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II.

31 March 2020

1 reference

A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics

31 March 2020

1 reference

Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics

31 March 2020

1 reference

Partial purification, specificity and mechanism of action of the nisin-inactivating enzyme from Bacillus cereus

31 March 2020

1 reference

Cell wall changes in nisin-resistant variants of Listeria innocua grown in the presence of high nisin concentrations

31 March 2020

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Involvement of the cell envelope of Listeria monocytogenes in the acquisition of nisin resistance

31 March 2020

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Compounds formed between nucleotides related to the biosynthesis of bacterial cell wall and vancomycin

31 March 2020

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Isolation and characterization of new peptide antibiotics, plusbacins A1-A4 and B1-B4

31 March 2020

1 reference

7 January 2021

Nisin resistance in Listeria monocytogenes ATCC 700302 is a complex phenotype

1 reference

7 January 2021

Nisin treatment for inactivation of Salmonella species and other gram-negative bacteria

1 reference

7 January 2021

Mersacidin, a new antibiotic from Bacillus. In vitro and in vivo antibacterial activity

1 reference

7 January 2021

Identifiers

DOI

10.1038/NRD2004

1 reference

14 August 2017

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PubMed ID

16531990