(Q36439708)

14 August 2017

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title

P2 receptors: intracellular signaling (English)

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14 August 2017

1

Laurie Erb

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14 August 2017

Zhongji Liao

2

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PubMed ID

16586093

14 August 2017

Cheikh I Seye

series ordinal

3

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PubMed ID

16586093

14 August 2017

Gary A Weisman

series ordinal

4

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14 August 2017

4 April 2006

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14 August 2017

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14 August 2017

452

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14 August 2017

5

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14 August 2017

552-562

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https://scigraph.springernature.com/pub.10.1007/s00424-006-0069-2

14 August 2017

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cites work

Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

Mechanisms of P2X7 receptor-mediated ERK1/2 phosphorylation in human astrocytoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

A nucleotide receptor in vascular endothelial cells is specifically activated by the fully ionized forms of ATP and UTP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

Synergy between the inositol phosphate responses to transfected human adenosine A1-receptors and constitutive P2-purinoceptors in CHO-K1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

Molecular physiology of P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

Role of G-protein beta gamma subunits in the augmentation of P2Y2 (P2U)receptor-stimulated responses by neuropeptide Y Y1 Gi/o-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

Overexpression of P2Y2 purinoceptor in intimal lesions of the rat aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

An ecdysone and tetracycline dual regulatory expression system for studies on Rac1 small GTPase-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-006-0069-2

P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen

21 January 2018

1 reference

12 December 2020

P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.

1 reference

12 December 2020

P2Y receptors activate neuroprotective mechanisms in astrocytic cells

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12 December 2020

G13 is an essential mediator of platelet activation in hemostasis and thrombosis

1 reference

12 December 2020

Ca(2+) signalling by recombinant human CXCR2 chemokine receptors is potentiated by P2Y nucleotide receptors in HEK cells

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12 December 2020

Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue

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12 December 2020

Coupling of the nucleotide P2Y4 receptor to neuronal ion channels

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12 December 2020

P2Y2 nucleotide receptor up-regulation in submandibular gland cells from the NOD.B10 mouse model of Sjögren's syndrome

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12 December 2020

Extracellular ATP enhances mRNA levels of nitric oxide synthase and TNF-alpha in lipopolysaccharide-treated RAW 264.7 murine macrophages.

1 reference

12 December 2020

Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes

1 reference

12 December 2020

Differential coupling of the human P2Y(11) receptor to phospholipase C and adenylyl cyclase

1 reference

12 December 2020

A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors

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12 December 2020

P2Y receptors modulate ion channel function through interactions involving the C-terminal domain.

1 reference

12 December 2020

ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor

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12 December 2020

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

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12 December 2020

Agonist-induced phosphorylation and desensitization of the P2Y2 nucleotide receptor

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12 December 2020

Characterisation of a recombinant P2Y purinoceptor

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12 December 2020

Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C

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12 December 2020

Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts

1 reference

12 December 2020

Functional modulation of P2X2 receptors by cyclic AMP-dependent protein kinase

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12 December 2020

ATP-stimulated activation of the mitogen-activated protein kinases through ionotrophic P2X2 purinoreceptors in PC12 cells. Difference in purinoreceptor sensitivity in two PC12 cell lines.

1 reference

12 December 2020

Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase

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12 December 2020

Inhibition by heterologously-expressed P2Y2 nucleotide receptors of N-type calcium currents in rat sympathetic neurones

1 reference

12 December 2020

G protein-coupled receptors and their signaling pathways: classical therapeutical targets susceptible to novel therapeutic concepts

1 reference

12 December 2020

Salivary gland nucleotide receptors: evidence for functional expression of both P2X and P2Y subtypes

1 reference

12 December 2020

Effects of synapsin I and calcium/calmodulin-dependent protein kinase II on spontaneous neurotransmitter release in the squid giant synapse

1 reference

12 December 2020

Platelet purinergic receptors

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12 December 2020

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12 December 2020

P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

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12 December 2020

MAPKK-dependent growth factor-induced upregulation of P2Y2 receptors in vascular smooth muscle cells

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12 December 2020

Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus

1 reference

12 December 2020

Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia

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12 December 2020

P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway

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12 December 2020

A G protein-coupled receptor for UDP-glucose

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12 December 2020

Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors

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12 December 2020

Nucleotide receptor P2u partially mediates ATP-induced cell cycle progression of aortic smooth muscle cells

1 reference

12 December 2020

Extracellular ATP Potentiates Nitric Oxide Synthase Expression Induced by Lipopolysaccharide in RAW-264.7 Murine Macrophages

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12 December 2020

Antiproliferative effect of UTP on human arterial and venous smooth muscle cells

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12 December 2020

ADP Receptors-Targets for Developing Antithrombotic Agents

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12 December 2020

Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors

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12 December 2020

P2U purinergic activation leads to the cell cycle progression from the G1 to the S and M phases but not from the G0 to G1 phase in vascular smooth muscle cells in primary culture

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12 December 2020

P2Y nucleotide receptor interaction with alpha integrin mediates astrocyte migration

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12 December 2020

Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits.

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12 December 2020

Purification and Functional Reconstitution of the Human P2Y12Receptor

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12 December 2020

Receptors for purines and pyrimidines

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12 December 2020

Introduction: P2 receptors

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12 December 2020

Inhibition of phospholipase A2-mediated arachidonic acid release by cyclic AMP defines a negative feedback loop for P2Y receptor activation in Madin-Darby canine kidney D1 cells

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12 December 2020

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

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12 December 2020

P2X7 receptor activates extracellular signal-regulated kinases ERK1 and ERK2 independently of Ca2+ influx

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12 December 2020

ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord

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12 December 2020

P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse

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12 December 2020

P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region

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12 December 2020

Desensitization of P2Y2 receptor-activated transepithelial anion secretion

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12 December 2020

A protein kinase C site highly conserved in P2X subunits controls the desensitization kinetics of P2X(2) ATP-gated channels

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12 December 2020

Identification of a novel human ADP receptor coupled to G(i)

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12 December 2020

Structural basis of agonist-induced desensitization and sequestration of the P2Y2 nucleotide receptor. Consequences of truncation of the C terminus.

1 reference

12 December 2020

Reversible regulation of P2Y(2) nucleotide receptor expression in the duct-ligated rat submandibular gland

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12 December 2020

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA

1 reference

12 December 2020

P2Y2 receptor-stimulated release of prostaglandin E2 by rat inner medullary collecting duct preparations.

1 reference

12 December 2020

Functional P2Y2 nucleotide receptors mediate uridine 5'-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries

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12 December 2020

The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes

1 reference

12 December 2020

Coexpression of ligand-gated P2X and G protein-coupled P2Y receptors in smooth muscle. Preferential activation of P2Y receptors coupled to phospholipase C (PLC)-beta1 via Galphaq/11 and to PLC-beta3 via Gbetagammai3.

1 reference

12 December 2020

ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling

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12 December 2020

Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling

1 reference

12 December 2020

Slow desensitization of the human P2Y6 receptor.

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12 December 2020

Pharmacology of cloned P2X receptors

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12 December 2020

Molecular characterization and pharmacological properties of the human P2X3 purinoceptor

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12 December 2020

The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration.

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12 December 2020

Molecular and functional characterization of human P2X(2) receptors.

1 reference

12 December 2020

Pharmacological characterization of the human P2Y4 receptor.

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12 December 2020

Differential agonist-induced desensitization of P2Y2 nucleotide receptors by ATP and UTP.

1 reference

12 December 2020

P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase.

1 reference

12 December 2020

ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain.

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12 December 2020

Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system

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12 December 2020

Characterization of a Ca2+ response to both UTP and ATP at human P2Y11 receptors: evidence for agonist-specific signaling

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12 December 2020

Bioassay of EDRF from internal mammary arteries: implications for early and late bypass graft patency

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12 December 2020

Heteromeric association creates a P2Y-like adenosine receptor

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12 December 2020

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

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12 December 2020

Selective regulation of endogenous G protein-coupled receptors by arrestins in HEK293 cells

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12 December 2020

Upregulation of P2Y2 nucleotide receptors in rat salivary gland cells during short-term culture

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12 December 2020

Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease

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12 December 2020

The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1).

1 reference

12 December 2020

Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages

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12 December 2020

Down-regulation of P2U-purinergic nucleotide receptor messenger RNA expression during in vitro differentiation of human myeloid leukocytes by phorbol esters or inflammatory activators.

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12 December 2020

Mechanisms of agonist-dependent and -independent desensitization of a recombinant P2Y2 nucleotide receptor

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12 December 2020

The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells

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12 December 2020

G-protein-coupled receptor regulation of P2X1 receptors does not involve direct channel phosphorylation

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12 December 2020

Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes

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12 December 2020

Phospholipase A(2) regulation of arachidonic acid mobilization

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12 December 2020

Cloning and chromosomal localization of the human P2Y1 purinoceptor

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12 December 2020

Identification of the platelet ADP receptor targeted by antithrombotic drugs

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12 December 2020

Pharmacology and electrophysiology of ATP-activated ion channels

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12 December 2020

Proteomic and functional evidence for a P2X7 receptor signalling complex

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12 December 2020

Cloning, functional expression and tissue distribution of the human P2Y6 receptor

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12 December 2020

Chloride secretory response to extracellular ATP in human normal and cystic fibrosis nasal epithelia

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12 December 2020

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12 December 2020

The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells

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12 December 2020

Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors

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12 December 2020

Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor.

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12 December 2020

Inhibition of potassium and calcium currents in neurones by molecularly-defined P2Y receptors

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12 December 2020

ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999

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12 December 2020

Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene

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12 December 2020

A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins

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12 December 2020

Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2receptor

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12 December 2020

Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis

1 reference

12 December 2020

P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells

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12 December 2020

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy

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12 December 2020

Differential heterologous and homologous desensitization of two receptors for ATP (P2y purinoceptors and nucleotide receptors) coexisting on endothelial cells

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12 December 2020

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

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12 December 2020

Prostaglandin E2 production in astrocytes: regulation by cytokines, extracellular ATP, and oxidative agents.

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12 December 2020

An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor

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12 December 2020

Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor

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12 December 2020

ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line

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12 December 2020

Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages

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12 December 2020

Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B.

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12 December 2020

Gi-dependent and -independent mechanisms downstream of the P2Y12 ADP-receptor

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12 December 2020

Covalent incorporation of 3'-O-(4-benzoyl)benzoyl-ATP into a P2 purinoceptor in transformed mouse fibroblasts

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12 December 2020

Global myocardial ischemia and reperfusion impair endothelium-dependent relaxations to aggregating platelets in the canine coronary artery. A possible cause of vasospasm after cardiopulmonary bypass

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12 December 2020

Cloning of the rat P2u receptor and its potential role in coronary vasodilation.

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12 December 2020

An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction

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12 December 2020

Activation of P2Y2 receptor induces c-FOS protein through a pathway involving mitogen-activated protein kinases and phosphoinositide 3-kinases in HeLa cells.

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12 December 2020

Extracellular UTP stimulates electrogenic bicarbonate secretion across CFTR knockout gallbladder epithelium

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12 December 2020

P2Y(2) nucleotide receptor signaling in human monocytic cells: activation, desensitization and coupling to mitogen-activated protein kinases

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12 December 2020

Pharmacological characterization of the human P2Y13 receptor

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12 December 2020

siRNA relieves chronic neuropathic pain

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12 December 2020

ATP-stimulated smooth muscle cell proliferation requires independent ERK and PI3K signaling pathways

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12 December 2020

P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.

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12 December 2020

ATP receptor-mediated synaptic currents in the central nervous system

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12 December 2020

Purinergic receptors are part of a signaling system for keratinocyte proliferation, differentiation, and apoptosis in human fetal epidermis

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12 December 2020

Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing

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12 December 2020

The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

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12 December 2020

Cloning and functional expression of a human uridine nucleotide receptor

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12 December 2020

Effect of loss of P2Y(2) receptor gene expression on nucleotide regulation of murine epithelial Cl(-) transport

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12 December 2020

Cloning of P2XM, a novel human P2X receptor gene regulated by p53

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12 December 2020

P2X receptors: a third major class of ligand-gated ion channels.

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12 December 2020

A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release

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12 December 2020

Structure and function of P2Y2 nucleotide receptors in cystic fibrosis (CF) epithelium

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12 December 2020

10.1007/S00424-006-0069-2

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16586093