(Q36440361)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

review article

1 reference

title

Ophthalmic drug design based on the metabolic activity of the eye: soft drugs and chemical delivery systems (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Nicholas Bodor

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

7 December 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

E820-33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1208/aapsj070479

19 January 2020

exact match

0 references

cites work

General linearized biexponential model for QSAR data showing bilinear-type distribution

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Anti-inflammatory effect and soft properties of etiprednol dicloacetate (BNP-166), a new, anti-asthmatic steroid.

30 September 2017

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Lessons learned from marketed and investigational prodrugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Long-term safety of loteprednol etabonate 0.2% in the treatment of seasonal and perennial allergic conjunctivitis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Recent advances in corticosteroids for the treatment of asthma.

30 September 2017

1 reference

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Locally administered ocular corticosteroids: benefits and risks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Primary drug treatment for glaucoma: beta-blockers versus other medications

30 September 2017

1 reference

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Side effects of corticosteroid therapy

30 September 2017

1 reference

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Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes

30 September 2017

1 reference

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Stereospecific pharmacokinetics and pharmacodynamics of beta-adrenergic blockers in humans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Transcriptional potencies of inhaled glucocorticoids.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Biopharmaceutical considerations in topical ocular drug delivery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Loteprednol etabonate: a review of ophthalmic clinical studies.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Soft drug design: general principles and recent applications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Beta-blocker eyedrops and nocturnal arterial hypotension

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

The potential systemic effect of topically applied beta-blockers in glaucoma therapy.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Enhancement of ocular drug penetration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Steroid-induced cataract: new perspective from in vitro and lens culture studies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Comparison of the ocular beta-blockers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Blood-eye barriers in the rat: correlation of ultrastructure with function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Ocular delivery of the beta-adrenergic antagonist alprenolol by sequential bioactivation of its methoxime analogue.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Clinical pharmacokinetics of metoprolol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Cortoic acids: explorations at the frontier of corticosteroid metabolism.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Formation of covalent adducts between cortisol and 16 alpha-hydroxyestrone and protein: possible role in the pathogenesis of cortisol toxicity and systemic lupus erythematosus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Nonenzymatic addition of glucocorticoids to lens proteins in steroid-induced cataracts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Corticosteroid-induced cataracts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Topical ocular drug delivery: recent developments and future challenges

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Ocular drug delivery. Pharmacokinetic considerations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Soft drugs--10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: loteprednol etabonate

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Effects of Induction of Cytochrome P-450 Enzymes on the Concentration of Foreign Compounds and Their Metabolites and on the Toxicological Effects of These Compounds

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Drug targeting via retrometabolic approaches

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Ocular-specific chemical delivery systems of betaxolol for safe local treatment of glaucoma.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

New approaches to antiglaucoma therapy

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Glucocorticoid-lens protein adducts in experimentally induced steroid cataracts

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Adverse respiratory and cardiovascular events attributed to timolol ophthalmic solution, 1978-1985.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Respiratory difficulties with betaxolol

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Topical beta-blocker therapy and central nervous system side effects. A preliminary study comparing betaxolol and timolol

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Pharmacokinetic characterization and tissue distribution of the new glucocorticoid soft drug loteprednol etabonate in rats and dogs

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Possibilities in improvement of glucocorticoid treatments in asthma with special reference to loteprednol etabonate

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Soft glucocorticoid design: structural elements and physicochemical parameters determining receptor-binding affinity.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Potency and specificity of the pharmacological action of a new, antiasthmatic, topically administered soft steroid, etiprednol dicloacetate (BNP-166).

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

28-day oral toxicity study with soft corticosteroid BNP-166 in rats and dogs, followed by a 14-day recovery period

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2750951

Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways

21 September 2018

1 reference

12 December 2020

A comparison of intraocular pressure elevating activity of loteprednol etabonate and dexamethasone in rabbits

1 reference

12 December 2020

Ocular absorption and distribution of loteprednol etabonate, a soft steroid, in rabbit eyes

1 reference

12 December 2020

Site- and stereospecific ocular drug delivery by sequential enzymatic bioactivation

1 reference

12 December 2020

BIOMEDICINE: Enhanced: A New Angle on Ocular Development

1 reference

12 December 2020

Soft Drugs VI. The Application of the Inactive Metabolite Approach for Design of Soft β-Blockers1?2

1 reference

12 December 2020

Mechanisms of corneal drug penetration. I: In vivo and in vitro kinetics

1 reference

12 December 2020

Corticosteroid therapy of eye disease. Fifty years later

1 reference

12 December 2020

Cardiac electrophysiologic effects of adaprolol maleate, a new β-blocker, in closed chest dogs

1 reference

12 December 2020

Timolol. A new drug for management of chronic simple glaucoma

1 reference

12 December 2020

Improved delivery through biological membranes. 26. Design, synthesis, and pharmacological activity of a novel chemical delivery system for beta-adrenergic blocking agents

1 reference

12 December 2020

Soft drugs. 18. Oral and rectal delivery of loteprednol etabonate, a novel soft corticosteroid, in rats--for safer treatment of gastrointestinal inflammation

1 reference

12 December 2020

Mechanism of transcorneal permeation of pilocarpine

1 reference

12 December 2020

Novel 'soft' beta-blockers as potential safe antiglaucoma agents

1 reference

12 December 2020

Loteprednol etabonate: clinical potential in the management of ocular inflammation

1 reference

12 December 2020

Synthesis and pharmacological activity of adaprolol enantiomers: a new soft drug for treating glaucoma

1 reference

12 December 2020

Stereospecificity of beta adrenergic antagonists: R-enantiomers show increased selectivity for beta-2 receptors in ciliary process

1 reference

12 December 2020

Modeling, design, chiral aspects and role of para-substituents in aryloxypropranolamine based beta-blockers

1 reference

12 December 2020

Regioselective O-alkylation of cortienic acid and synthesis of a new class of glucocorticoids containing a 17 alpha-alkoxy, a 17 alpha-(1'-alkoxyethyloxy), a 17 alpha-alkoxymethyloxy, or a 17 alpha-methylthiomethyloxy function

1 reference

12 December 2020

Effect of a novel soft steroid on the wound healing of rabbit cornea

1 reference

12 December 2020

Ocular-specific delivery of timolol by sequential bioactivation of its oxime and methoxime analogs

1 reference

12 December 2020

Sexual dysfunction secondary to topical ophthalmic timolol

1 reference

12 December 2020

Timolol-induced bronchospasm in asthmatic bronchitis

1 reference

12 December 2020

Betaxolol in patients with glaucoma and asthma

1 reference

12 December 2020

Predicted permeability of the cornea to topical drugs

1 reference

12 December 2020

Minimal cardiac electrophysiological activity of alprenoxime, a site-activated ocular beta-blocker, in dogs

1 reference

12 December 2020

Change in intraocular pressure during long-term use of loteprednol etabonate

1 reference

12 December 2020

Metabolism, distribution, and transdermal permeation of a soft corticosteroid, loteprednol etabonate

1 reference

12 December 2020

Metabolism of metoprolol-(3-h) in man, the dog and the rat

1 reference

12 December 2020

Soft drugs. 7. Soft .beta.-blockers for systemic and ophthalmic use

1 reference

12 December 2020

Soft drugs. 19. Pharmacokinetics, metabolism and excretion of a novel soft corticosteroid, loteprednol etabonate, in rats

1 reference

12 December 2020

Improved delivery through biological membranes. LVI. Pharmacological evaluation of alprenoxime--a new potential antiglaucoma agent

1 reference

12 December 2020

Failure to detect systemic levels, and effects of loteprednol etabonate and its metabolite, PJ-91, following chronic ocular administration

1 reference

12 December 2020

Identifiers

DOI

10.1208/AAPSJ070479

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16594634%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

16594634

1 reference