(Q36440674)

14 August 2017

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title

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling (English)

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14 August 2017

2

Robert J Lefkowitz

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14 August 2017

Eric Reiter

1

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14 August 2017

publication date

3 April 2006

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Trends in Endocrinology and Metabolism

14 August 2017

published in

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14 August 2017

volume

17

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14 August 2017

issue

4

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14 August 2017

page(s)

159-165

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Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*

14 August 2017

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Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

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Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

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Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation

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Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells

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Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

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Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling

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11 October 2022

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Transduction of receptor signals by beta-arrestins

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11 October 2022

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A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis

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Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Mechanisms of beta-adrenergic receptor desensitization and resensitization

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

GPCR interacting proteins (GIP).

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Identification of G protein-coupled receptor genes from the human genome sequence

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

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11 October 2022

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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

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11 October 2022

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G protein-coupled receptor kinases

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Signaling at zero G: G-protein-independent functions for 7-TM receptors

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11 October 2022

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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

The origins of diversity and specificity in g protein-coupled receptor signaling

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Homo- and hetero-oligomerization of beta-arrestins in living cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Inverse, protean, and ligand-selective agonism: matters of receptor conformation

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Recent advances in drug action and therapeutics: relevance of novel concepts in G-protein-coupled receptor and signal transduction pharmacology

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

The ins and outs of G protein-coupled receptor trafficking

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Seven-transmembrane receptors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

beta-arrestins: traffic cops of cell signaling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Arrestins block G protein-coupled receptor-mediated apoptosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Beta-arrestin-2 regulates the development of allergic asthma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TEM.2006.03.008

Identifiers

DOI

10.1016/J.TEM.2006.03.008

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14 August 2017

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