(Q36444280)

English

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

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scholarly article

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Europe PubMed Central

PMC publication ID

14 August 2017

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

pancreatic cancer

1 reference

based on heuristic

inferred from title

cancer metastasis

1 reference

based on heuristic

inferred from title

author name string

Ken Fujimura

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Sunkyu Choi

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Meghan Wyse

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Jan Strnadel

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Tracy Wright

5

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Richard Klemke

6

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

0 references

publication date

19 October 2015

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

number of pages

13

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

290

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

50

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

29907-29919

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4706006/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The translation factor eIF5A and human cancer

1 reference

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30 September 2017

KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach

1 reference

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30 September 2017

Genome-wide analyses and functional classification of proline repeat-rich proteins: potential role of eIF5A in eukaryotic evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

eIF5A promotes translation of polyproline motifs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Divergent protein motifs direct elongation factor P-mediated translational regulation in Salmonella enterica and Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Rebuilding cancer metastasis in the mouse

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Proline: the distribution, frequency, positioning, and common functional roles of proline and polyproline sequences in the human proteome

1 reference

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30 September 2017

RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Role of connexins in metastatic breast cancer and melanoma brain colonization

1 reference

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30 September 2017

Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Metastatic pancreatic cancer is dependent on oncogenic Kras in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

EMT and dissemination precede pancreatic tumor formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Directed cell invasion and migration during metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Rapid and quantitative assessment of cell quality, identity, and functionality for cell-based assays using real-time cellular analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Pancreatic cancer: the role of pancreatic stellate cells in tumor progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Hypusine: a new target for therapeutic intervention in diabetic inflammation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

eIF5A promotes translation elongation, polysome disassembly and stress granule assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Regulation of actin assembly associated with protrusion and adhesion in cell migration

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression

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30 September 2017

The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)

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30 September 2017

Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations

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30 September 2017

The PANTHER database of protein families, subfamilies, functions and pathways

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30 September 2017

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Rocks: multifunctional kinases in cell behaviour

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

Metastatic pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

30 September 2017

In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice

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30 September 2017

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30 September 2017

Overexpression of RhoA promotes the proliferation and migration of cervical cancer cells.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4706006

21 September 2018

EF-P is essential for rapid synthesis of proteins containing consecutive proline residues

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21 September 2018

Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches.

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21 September 2018

Adaptation of energy metabolism in breast cancer brain metastases

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21 September 2018

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

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21 September 2018

FFAS03: a server for profile--profile sequence alignments

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21 January 2018

Clinical and prognostic significance of RhoA and RhoC gene expression in esophageal squamous cell carcinoma

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12 December 2020

based on heuristic

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Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26483550

12 December 2020

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Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer

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https://pubmed.ncbi.nlm.nih.gov/26483550

12 December 2020

based on heuristic

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Identifiers

10.1074/JBC.M115.687418

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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