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RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation.
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Europe PubMed Central
PMC publication ID
3514411
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
title
RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation
(English)
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Europe PubMed Central
PMC publication ID
3514411
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retrieved
16 January 2020
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RNA-binding proteins
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author
Stephen M. Lewis
series ordinal
2
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Europe PubMed Central
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3514411
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102524%20AND%20SRC:MED&resulttype=core&format=json
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16 January 2020
Martin Holcik
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6
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Europe PubMed Central
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3514411
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102524%20AND%20SRC:MED&resulttype=core&format=json
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16 January 2020
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D Durie
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1
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3514411
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16 January 2020
U Liwak
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3
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16 January 2020
M Kisilewicz
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4
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3514411
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16 January 2020
M Gorospe
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5
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Europe PubMed Central
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3514411
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16 January 2020
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English
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publication date
22 November 2010
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3514411
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16 January 2020
published in
Oncogene
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3514411
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16 January 2020
volume
30
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Europe PubMed Central
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3514411
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
issue
12
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Europe PubMed Central
PMC publication ID
3514411
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
page(s)
1460-1469
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Europe PubMed Central
PMC publication ID
3514411
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
exact match
https://scigraph.springernature.com/pub.10.1038/onc.2010.527
0 references
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NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response
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30 September 2017
Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines
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30 September 2017
Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia
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Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.
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30 September 2017
Regulation of XIAP translation and induction by MDM2 following irradiation
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer
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30 September 2017
Structure and activity of the internal ribosome entry site within the human p27 Kip1 5'-untranslated region.
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30 September 2017
Tissue microarray analysis of 560 patients with colorectal adenocarcinoma: high expression of HuR predicts poor survival
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Diverse molecular functions of Hu proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
IAPs: more than just inhibitors of apoptosis proteins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
X-linked inhibitor of apoptosis protein as a therapeutic target
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PubMed Central
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30 September 2017
A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
A search for structurally similar cellular internal ribosome entry sites.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Posttranscriptional orchestration of an anti-apoptotic program by HuR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Targeting XIAP for the treatment of malignancy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Translational control in stress and apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Upstream regulatory role for XIAP in receptor-mediated apoptosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Translational upregulation of the X-linked inhibitor of apoptosis.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
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30 September 2017
The inhibitors of apoptosis: there is more to life than Bcl2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Internal ribosome initiation of translation and the control of cell death.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
30 September 2017
The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
28 June 2018
Spurious splicing within the XIAP 5' UTR occurs in the Rluc/Fluc but not the betagal/CAT bicistronic reporter system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
28 June 2018
Use of Escherichiu coli (E. coli) lacZ (β-Galactosidase) as a Reporter Gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
21 September 2018
The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
21 September 2018
Prognostic role of HuR in hereditary breast cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
21 September 2018
Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
21 September 2018
High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
21 September 2018
Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514411
retrieved
21 September 2018
Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FONC.2010.527
retrieved
31 March 2020
XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FONC.2010.527
retrieved
31 March 2020
Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21102524
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/ONC.2010.527
1 reference
stated in
Europe PubMed Central
PMC publication ID
3514411
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
PMC publication ID
3514411
1 reference
stated in
Europe PubMed Central
PMC publication ID
3514411
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
PubMed publication ID
21102524
1 reference
stated in
Europe PubMed Central
PMC publication ID
3514411
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21102524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
ResearchGate publication ID
49631070
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