(Q37008849)

17 August 2017

1 reference

title

X-linked inhibitor of apoptosis protein as a therapeutic target (English)

1 reference

17 August 2017

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Emma J Dean

1

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Fiona Blackhall

object named as

Fiona Blackhall

series ordinal

3

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Caroline Dive

object named as

Caroline Dive

series ordinal

4

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Malcolm Ranson

series ordinal

2

object named as

Malcolm Ranson

1 reference

17 August 2017

language of work or name

English

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publication date

1 November 2007

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Expert Opinion on Therapeutic Targets

17 August 2017

published in

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17 August 2017

volume

11

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17 August 2017

issue

11

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17 August 2017

page(s)

1459-1471

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17 August 2017

cites work

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Erlotinib in previously treated non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Four deaths and a funeral: from caspases to alternative mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Mechanisms of caspase activation and inhibition during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Pro-caspase-3 is a major physiologic target of caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Caspase activation: the induced-proximity model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Caspases: the executioners of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Bid, a BH3-only multi-functional molecule, is at the cross road of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

X-linked IAP is a direct inhibitor of cell-death proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

IAP proteins: blocking the road to death's door

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Control of apoptosis and mitotic spindle checkpoint by survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

A single BIR domain of XIAP sufficient for inhibiting caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

A human IAP-family gene, apollon, expressed in human brain cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Livin, a novel inhibitor of apoptosis protein family member

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

The inhibitors of apoptosis: there is more to life than Bcl2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

XIAP expression is an independent prognostic marker in clear-cell renal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Inhibitors of apoptosis proteins in human cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Upstream regulatory role for XIAP in receptor-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Characterization of XIAP-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Mechanism of XIAP-mediated inhibition of caspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Detection of autoantibodies to survivin and livin in sera from patients with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

XIAP protection of photoreceptors in animal models of retinitis pigmentosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

Cell suicide for beginners

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.11.1459

10.1517/14728222.11.11.1459

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference