(Q36445356)

14 August 2017

1 reference

title

Understanding mechanisms of gamma-globin gene regulation to develop strategies for pharmacological fetal hemoglobin induction (English)

1 reference

14 August 2017

Betty S Pace

1

0 references

author name string

Sima Zein

series ordinal

2

1 reference

14 August 2017

publication date

1 July 2006

1 reference

14 August 2017

published in

Developmental Dynamics

1 reference

14 August 2017

volume

235

1 reference

14 August 2017

issue

7

1 reference

14 August 2017

page(s)

1727-1737

1 reference

FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes

14 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

Nuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

Methylation-enhanced binding of Sp1 to the stage selector element of the human gamma-globin gene promoter may regulate development specificity of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

Developmental regulation of human gamma-globin genes in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Bone and joint disease in sickle cell disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Stimulation of fetal hemoglobin synthesis by erythropoietin in baboons

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Changes in the G gamma- and A gamma-globin mRNA components of fetal hemoglobin during human development.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Human gamma- to beta-globin gene switching in transgenic mice.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

A sustained and pancellular reversal of gamma-globin gene silencing in adult human erythroid precursor cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Reactivation of Fetal Hemoglobin in Adult Stem Cell Erythropoiesis by Transforming Growth Factor-β

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Role of hybrid tetramer formation in gelation of haemoglobin S

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Polymerisation of haemoglobin SA hybrid tetramers

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Abrogation of IL-3 requirements and stimulation of hematopoietic cell proliferation in vitro and in vivo by carboxylic acids

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

The molecular pathobiology of cell membrane iron: the sickle red cell as a model

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Sodium butyrate inhibits histone deacetylation in cultured cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Induction of human gamma globin gene expression by histone deacetylase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

The tumorigenicity of 5-azacytidine in the male Fischer rat.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

The relative importance of the X-linked FCP locus and beta-globin haplotypes in determining haemoglobin F levels: a study of SS patients homozygous for beta S haplotypes.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Molecular mechanisms of erythropoietin signaling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

STATs and gene regulation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Incidence and natural history of proliferative sickle cell retinopathy: observations from a cohort study

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Globin gene silencing in primary erythroid cultures. An inhibitory role for interleukin-6.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Stat3 beta inhibits gamma-globin gene expression in erythroid cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Locus control regions, chromatin activation and transcription

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

A novel C-T transition within the distal CCAAT motif of the Gγ-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Mechanism of Hb F stimulation by S-stage compounds. In vitro studies with bone marrow cells exposed to 5-azacytidine, Ara-C, or hydroxyurea

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

In vivo formation of a human beta-globin locus control region core element requires binding sites for multiple factors including GATA-1, NF-E2, erythroid Kruppel-like factor, and Sp1.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Gene expression in proliferating human erythroid cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Stimulation of the cyclic GMP pathway by NO induces expression of the immediate early genes c-fos and junB in PC12 cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Electronic access to sequence alignments, experimental results, and human mutations as an aid to studying globin gene regulation.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Beta-globin locus control region HS2 and HS3 interact structurally and functionally

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Evolution of the hemoglobin S and C genes in world populations

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Time resolved absorption study of the reaction of hydroxyurea with sickle cell hemoglobin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

A role for nitric oxide in hydroxyurea-mediated fetal hemoglobin induction

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Hematological observations on Arabian SS patients with a homozygosity or heterozygosity for a beta S chromosome with haplotype #31

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Roles of histone acetyltransferases and deacetylases in gene regulation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

The molecular mechanism of fetal hemoglobin reactivation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Transcription patterning of uncoupled proliferation and differentiation in myelodysplastic bone marrow with erythroid-focused arrays

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Augmentation of Fetal-Hemoglobin Production in Anemic Monkeys by Hydroxyurea

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Treatment of severe β-thalassemia (patients) with myleran

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

The effects of HPFH mutations in the human gamma-globin promoter on binding of ubiquitous and erythroid specific nuclear factors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Nucleotide sequence analysis of coding and noncoding regions of human beta-globin mRNA

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

S-phase inhibitors induce vimentin expression in human promonocytic U-937 cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Linking histone acetylation to transcriptional regulation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Role of c-Kit and erythropoietin receptor in erythropoiesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Hematologically and genetically distinct forms of sickle cell anemia in Africa. The Senegal type and the Benin type

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

PRAK, a novel protein kinase regulated by the p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Hemolysis-associated priapism in sickle cell disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Histone acetylation reduces nucleosome core particle linking number change

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Arabinosylcytosine Induces Fetal Hemoglobin in Baboons by Perturbing Erythroid Cell Differentiation Kinetics

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Butyric acid modulates developmental globin gene switching in man and sheep.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Pain in sickle cell disease. Rates and risk factors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Sickle cell anemia and major organ failure

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Sickle cell disease: the neurological complications

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

The role of the -50 region of the human gamma-globin gene in switching

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Increased Sp1 binding mediates erythroid-specific overexpression of a mutated (HPFH) gamma-globulin promoter

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Evidence for multiple structural genes for the gamma chain of human fetal hemoglobin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

The hydroxyurea-induced small GTP-binding protein SAR modulates gamma-globin gene expression in human erythroid cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Acute splenic sequestration and hypersplenism in the first five years in homozygous sickle cell disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Erythroid progenitor proliferation is stimulated by phenoxyacetic and phenylalkyl acids

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Human globin locus activation region (LAR): role in temporal control

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

CAAT/enhancer-binding proteins are involved in beta-globin gene expression and are differentially expressed in murine erythroleukemia and K562 cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Cytokine receptor signal transduction and the control of hematopoietic cell development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

The significance of the paucity of sickle cells in newborn Negro infants

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Butyrate increases the efficiency of translation of gamma-globin mRNA.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Induction of fetal hemoglobin synthesis by valproate: modulation of MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Signal transduction in the erythropoietin receptor system

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Increased HbF in adult life

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Control of haemoglobin switching by a developmental clock?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20802

7 January 2021

Identifiers

DOI

10.1002/DVDY.20802

1 reference

14 August 2017

1 reference