(Q36447889)

English

Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation

scientific article published on 11 September 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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Coagulation factor VIII

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0 references

1 reference

based on heuristic

inferred from title

object named as

Shannon L Meeks

1

0 references

author name string

John F Healey

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Ernest T Parker

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Rachel T Barrow

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Pete Lollar

5

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

0 references

publication date

11 September 2007

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

110

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

13

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

4234-4242

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

The humoral response to human factor VIII in hemophilia A mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

A1 subunit-mediated regulation of thrombin-activated factor VIII A2 subunit dissociation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Antigenicity of putative phospholipid membrane-binding residues in factor VIII.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Structure of the C2 domain of human factor VIII at 1.5 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Mechanism and kinetics of factor VIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Interactions of protein antigens with antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Structural features of the reactions between antibodies and protein antigens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Protein motion and lock and key complementarity in antigen-antibody reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Association of the factor VIII light chain with von Willebrand factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Factor VIII inhibitors. Etiology, characterization, natural history, and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Antibody-antigen complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

30 September 2017

Slowed release of thrombin-cleaved factor VIII from von Willebrand factor by a monoclonal and a human antibody is a novel mechanism for factor VIII inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

28 June 2018

Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

28 June 2018

CDR3 length in antigen-specific immune receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

28 June 2018

A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

28 June 2018

pH-dependent denaturation of thrombin-activated porcine factor VIII.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

28 June 2018

Coagulant properties of hybrid human/porcine factor VIII molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

28 June 2018

Neutralization of antifactor VIII inhibitors by recombinant porcine factor VIII.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

Reduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

The safety and efficacy of B-domain deleted recombinant factor VIII concentrate in patients with severe haemophilia A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

Inhibitor development in previously untreated patients with hemophilia A: a prospective long-term follow-up comparing plasma-derived and recombinant products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

Use of surface plasmon resonance for studies of protein-protein and protein-phospholipid membrane interactions. Application to the binding of factor VIII to von Willebrand factor and to phosphatidylserine-containing membranes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

The inhibitor antibody response is more complex in hemophilia A patients than in most nonhemophiliacs with factor VIII autoantibodies. Recombinate and Kogenate Study Groups.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

Common inhibitory effects of human anti-C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

Interaction of factor VIII-von Willebrand Factor with phospholipid vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234776

21 September 2018

Factor VIII C2 domain contains the thrombin-binding site responsible for thrombin-catalyzed cleavage at Arg1689

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Letter: A more uniform measurement of factor VIII inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human factor VIII procoagulant activity and phospholipid interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A factor VIII neutralizing monoclonal antibody and a human inhibitor alloantibody recognizing epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for the C2 domain of factor VIII in binding to von Willebrand factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanism for inhibition of factor VIII binding to phospholipid by von Willebrand factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von willebrand factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of factor VIII C2 domain in factor VIII binding to factor Xa

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of factor VIII coagulant activity by two different types of human antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subunit structure of thrombin-activated porcine factor VIII

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

von Willebrand factor is a cofactor for thrombin-catalyzed cleavage of the factor VIII light chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrinsic pathway activation of factor X and its activation peptide-deficient derivative, factor Xdes-143-191

1 reference

https://pubmed.ncbi.nlm.nih.gov/17848617

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2007-06-096842

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

0 references

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