(Q36455499)

14 August 2017

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title

Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma (English)

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14 August 2017

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Mark Branda

1

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14 August 2017

Jack R Wands

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 May 2006

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14 August 2017

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14 August 2017

volume

43

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14 August 2017

issue

5

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14 August 2017

page(s)

891-902

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Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

14 August 2017

cites work

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Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

21 January 2018

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

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Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line

21 January 2018

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Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases

21 January 2018

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Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos

21 January 2018

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Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis

21 January 2018

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Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection

21 January 2018

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Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX

21 January 2018

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Activation of calcium signaling by hepatitis B virus-X protein in liver cells

21 January 2018

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Erk-independent partial activation of AP-1 sites by the hepatitis B virus HBx protein

21 January 2018

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Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

21 January 2018

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Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth

21 January 2018

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Hepatitis C virus core protein induces hepatic steatosis in transgenic mice

21 January 2018

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Intracellular localization of the hepatitis B virus HBx protein.

21 January 2018

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21 January 2018

Hepatocellular carcinoma

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7 January 2021

Prevention of hepatocellular carcinoma

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7 January 2021

Rising incidence of hepatocellular carcinoma in the United States

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7 January 2021

Epidemiology of primary liver cancer

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7 January 2021

Case-control study on hepatitis C virus (HCV) as a risk factor for hepatocellular carcinoma: the role of HCV genotypes and the synergism with hepatitis B virus and alcohol. Brescia HCC Study

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7 January 2021

Risk factors for the rising rates of primary liver cancer in the United States

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7 January 2021

In vivo expression of two novel tumor-associated antigens and their use in immunolocalization of human hepatocellular carcinoma

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7 January 2021

Cell-surface changes associated with transformation of human hepatocytes to the malignant phenotype

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7 January 2021

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma

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7 January 2021

Immunological approach to hepatocellular carcinoma.

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7 January 2021

The IRS-1 signaling system

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7 January 2021

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

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7 January 2021

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

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7 January 2021

How MAP kinases are regulated

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7 January 2021

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

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7 January 2021

Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.

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7 January 2021

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

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7 January 2021

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

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7 January 2021

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

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7 January 2021

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

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7 January 2021

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

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7 January 2021

Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development

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7 January 2021

Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules

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7 January 2021

Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes

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7 January 2021

A carboxy-terminal truncated insulin receptor substrate-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype

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7 January 2021

Ethanol inhibits hepatocyte proliferation in insulin receptor substrate 1 transgenic mice

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7 January 2021

Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification

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7 January 2021

Beta-catenin is temporally regulated during normal liver development

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7 January 2021

Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration

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7 January 2021

Morpholino oligonucleotide-triggered beta-catenin knockdown compromises normal liver regeneration

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7 January 2021

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner

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7 January 2021

Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus

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7 January 2021

Specificity of WNT-receptor interactions

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7 January 2021

The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling

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7 January 2021

A new member of the frizzled family from Drosophila functions as a Wingless receptor

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7 January 2021

Secreted Frizzled-related proteins: searching for relationships and patterns

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7 January 2021

Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma

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7 January 2021

Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver

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7 January 2021

New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism

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7 January 2021

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

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7 January 2021

CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1.

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7 January 2021

The oncogenic activation of beta-catenin

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7 January 2021

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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7 January 2021

Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

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7 January 2021

Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

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7 January 2021

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

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7 January 2021

Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma

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7 January 2021

Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma.

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7 January 2021

A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals

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7 January 2021

Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC

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7 January 2021

PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma

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7 January 2021

Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer

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7 January 2021

Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma

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7 January 2021

TGF-beta1-promoted epithelial-to-mesenchymal transformation and cell adhesion contribute to TGF-beta1-enhanced cell migration in SMMC-7721 cells

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7 January 2021

Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition

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7 January 2021

Molecular basis of hepatitis C virus-associated hepatocarcinogenesis: lessons from animal model studies

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7 January 2021

The enigmatic X gene of hepatitis B virus

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7 January 2021

X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis

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7 January 2021

The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors

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7 January 2021

Hepadnaviral X Protein:Review of Recent Progress

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7 January 2021

Detection of the hepatitis B virus X protein (HBx) antigen and anti-HBx antibodies in cases of human hepatocellular carcinoma

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7 January 2021

Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms

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7 January 2021

Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma

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7 January 2021

HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis

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7 January 2021

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

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7 January 2021

Hepatocarcinogenesis in hepatitis viral infection: lessons from transgenic mouse studies

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7 January 2021

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene

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7 January 2021

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

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7 January 2021

Hepatitis B virus and hepatocellular carcinoma

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7 January 2021

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

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7 January 2021

Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells.

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7 January 2021

Reactive oxygen species modulates the intracellular level of HBx viral oncoprotein

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7 January 2021

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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7 January 2021

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

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7 January 2021

Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases

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7 January 2021

Activation of protooncogene c-jun by the X protein of hepatitis B virus

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7 January 2021

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

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7 January 2021

Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.

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7 January 2021

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade

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7 January 2021

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

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7 January 2021

Phosphorylation of c-jun mediated by MAP kinases.

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7 January 2021

Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo

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7 January 2021

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

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7 January 2021

Calcium signaling by HBx protein in hepatitis B virus DNA replication

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7 January 2021

Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes

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7 January 2021

Signal peptide peptidase promotes the formation of hepatitis C virus non-enveloped particles and is captured on the viral membrane during assembly

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7 January 2021

Hepatitis C virus core protein: intriguing properties and functional relevance

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7 January 2021

The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice

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7 January 2021

Expression of hepatitis C virus envelope proteins in transgenic mice

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7 January 2021

Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus

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7 January 2021

Transgenic expression of hepatitis C virus structural proteins in the mouse

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7 January 2021

Hepatitis C virus core and E2 protein expression in transgenic mice

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7 January 2021

Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype

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7 January 2021

Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene

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7 January 2021

Hepatitis C virus core protein regulates cell growth and signal transduction pathway transmitting growth stimuli

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7 January 2021

Hepatitis C virus core protein promotes immortalization of primary human hepatocytes

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7 January 2021

Hepatitis C virus core protein is necessary for the maintenance of immortalized human hepatocytes

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7 January 2021

Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression

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7 January 2021

Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.

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7 January 2021

Characterization of a HCV NS5A protein derived from a patient with hepatoma.

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7 January 2021

Expression of hepatitis C virus non-structural 5A protein in the liver of transgenic mice

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7 January 2021

Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice

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7 January 2021

The oncogenic potential of hepatitis C virus NS5A sequence variants is associated with PKR regulation

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7 January 2021

Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase

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7 January 2021

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade

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7 January 2021

Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription

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7 January 2021

Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways

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7 January 2021

Perturbations of the AKT signaling pathway in human cancer

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7 January 2021

Identifiers

DOI

10.1002/HEP.21196

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14 August 2017

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