(Q36459995)

14 August 2017

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title

Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases (English)

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14 August 2017

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reactive oxygen species

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Peter Storz

1

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14 August 2017

publication date

25 April 2006

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Science's STKE : signal transduction knowledge environment

14 August 2017

published in

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14 August 2017

volume

2006

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14 August 2017

issue

332

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14 August 2017

page(s)

re3

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Mitochondrial genetics and disease

14 August 2017

cites work

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Genetics and the specificity of the aging process

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ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

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Radical medicine: treating ageing to cure disease

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Aging: a theory based on free radical and radiation chemistry

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A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants

21 January 2018

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Oxidative stress, caloric restriction, and aging

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FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies

21 January 2018

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A role for mitochondria as potential regulators of cellular life span

21 January 2018

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Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

21 January 2018

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Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

21 January 2018

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Mitochondrial disease in superoxide dismutase 2 mutant mice

21 January 2018

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

21 January 2018

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Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species

21 January 2018

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Reactive oxygen species in tumor progression

21 January 2018

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Mitochondrial free radical production and cell signaling

21 January 2018

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Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

21 January 2018

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The mitochondrial permeability transition pore and its role in cell death

21 January 2018

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VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

21 January 2018

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Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells

21 January 2018

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A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage.

21 January 2018

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Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro

21 January 2018

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Oxidant signals and oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis

21 January 2018

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Peroxiredoxins, oxidative stress, and cell proliferation.

21 January 2018

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Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

21 January 2018

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Structure, mechanism and regulation of peroxiredoxins

21 January 2018

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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

21 January 2018

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Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

21 January 2018

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

21 January 2018

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Redox redux: revisiting PTPs and the control of cell signaling

21 January 2018

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Redox-linked signal transduction pathways for protein tyrosine kinase activation

21 January 2018

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Oxidants painting the cysteine chapel: redox regulation of PTPs

21 January 2018

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Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

21 January 2018

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Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death

21 January 2018

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Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.

21 January 2018

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Tyrosine phosphatase activity in mitochondria: presence of Shp-2 phosphatase in mitochondria

21 January 2018

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Tyrosine phosphorylation in mitochondria: a new frontier in mitochondrial signaling.

21 January 2018

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Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling

21 January 2018

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Reversible inactivation of the tumor suppressor PTEN by H2O2

21 January 2018

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Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein

21 January 2018

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Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Regulation of cytochrome c oxidase activity by c-Src in osteoclasts

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

The endocrine regulation of aging by insulin-like signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Regulation of oxidative stress by the anti-aging hormone klotho

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

21 January 2018

Free radicals and aging.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Mitochondria, oxidants, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Role of free radicals in aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Ageing and the mystery at Arles

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Molecular pathways to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Oxidative stress in neurodegeneration: cause or consequence?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Extension of murine life span by overexpression of catalase targeted to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Mitochondrial integrity and function in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

An overview of the relationship between oxidative stress and chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Prooxidant states and tumor promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Genetic pathways that regulate ageing in model organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.3322006RE3

21 January 2018

Identifiers

DOI

10.1126/STKE.3322006RE3

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14 August 2017

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