(Q36462041)

English

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism.

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16 February 2020

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism (English)

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16 February 2020

Rakesh Srivastava

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16 February 2020

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Stephen L Pinkosky

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16 February 2020

Sergey Filippov

2

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16 February 2020

Jeffrey C Hanselman

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16 February 2020

Cheryl D Bradshaw

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16 February 2020

Timothy R Hurley

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16 February 2020

Clay T Cramer

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16 February 2020

Mark A Spahr

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16 February 2020

Ashley F Brant

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16 February 2020

Jacob L Houghton

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16 February 2020

Chris Baker

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16 February 2020

Mark Naples

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16 February 2020

Khosrow Adeli

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16 February 2020

Roger S Newton

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16 February 2020

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1 November 2012

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16 February 2020

Journal of Lipid Research

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16 February 2020

54

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16 February 2020

1

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16 February 2020

134-151

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16 February 2020

Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.

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Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative.

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30 September 2017

Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid composition in mice

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30 September 2017

Management of the patient with statin intolerance

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Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice

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30 September 2017

ATP-citrate lyase links cellular metabolism to histone acetylation

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30 September 2017

Genetic predisposition to statin myopathy

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30 September 2017

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

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30 September 2017

AMPK activation by long chain fatty acyl analogs

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30 September 2017

Insulin sensitivity: modulation by nutrients and inflammation

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30 September 2017

Novel black soy peptides with antiobesity effects: activation of leptin-like signaling and AMP-activated protein kinase

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30 September 2017

Selective versus total insulin resistance: a pathogenic paradox

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30 September 2017

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

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30 September 2017

Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase.

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes

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30 September 2017

Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells

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30 September 2017

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

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30 September 2017

Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids

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30 September 2017

Intensive versus moderate lipid lowering with statins after acute coronary syndromes

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Effective strategies for long-term statin use

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30 September 2017

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

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30 September 2017

Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase

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Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

Modulation of the enzymic activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase by multiple kinase systems involving reversible phosphorylation: a review

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30 September 2017

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16).

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28 June 2018

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28 June 2018

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21 September 2018

Clinical and laboratory phenotype of patients experiencing statin intolerance attributable to myalgia.

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21 September 2018

Evaluation of anti-atherosclerotic activities of PPAR-α, PPAR-γ, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters.

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21 September 2018

Anti-hyperlipidemic and insulin sensitizing activities of fenofibrate reduces aortic lipid deposition in hyperlipidemic Golden Syrian hamster

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21 September 2018

Newer agents for blood glucose control in type 2 diabetes: summary of NICE guidance.

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21 September 2018

Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice

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21 September 2018

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.

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21 September 2018

Sequential changes in the signal transduction responses of skeletal muscle following food deprivation.

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21 September 2018

Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice.

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21 September 2018

Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats

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21 September 2018

Effects of a novel dual lipid synthesis inhibitor and its potential utility in treating dyslipidemia and metabolic syndrome

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21 September 2018

AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520520

21 September 2018

Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520520

21 September 2018

Regulation of lipid metabolism and gene expression by fenofibrate in hamsters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520520

21 September 2018

High fat fed hamster, a unique animal model for treatment of diabetic dyslipidemia with peroxisome proliferator activated receptor alpha selective agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520520

21 September 2018

Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520520

21 September 2018

Suppression of hepatocyte nuclear factor-4alpha by acyl-CoA thioesters of hypolipidemic peroxisome proliferators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520520

21 September 2018

Multisite control of the Crabtree effect in ascites hepatoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520520

21 September 2018

Tricarballylate and hydroxycitrate: substrate and inhibitor of ATP: citrate oxaloacetate lyase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520520

21 September 2018

Effects of hyperlipidemias in hamsters on lipid transfer protein activity and unidirectional cholesteryl ester transfer in plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520520

21 September 2018

Effective strategies for long-term statin use

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M030528

21 January 2018

Inhibition of cholesterol synthesis by (-)-hydroxycitrate in perfused rat liver. Evidence for an extramitochondrial mevalonate synthesis from acetyl coenzyme A

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-β-Hydroxysterol synthesis by the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitate activates AMP-activated protein kinase and regulates insulin secretion from beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and hypolipidemic and antidiabetogenic activities of beta,beta,beta',beta'-tetrasubstituted, long-chain dioic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thia fatty acids, metabolism and metabolic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The logic linking protein acetylation and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypolipidemic, antiobesity, and hypoglycemic-hypoinsulinemic effects of beta,beta'-methyl-substituted hexadecanedioic acid in sand rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of (—)-Hydroxycitrate on Fatty Acid Synthesis by Rat Liver in Vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hupolipidemic activity of (--)-hydroxycitrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species differences in induction of hepatic enzymes by BM 17.0744, an activator of peroxisome proliferator-activated receptor alpha (PPARalpha)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of enzymes which interact with citrate by (--)hydroxycitrate and 1,2,3,-tricarboxybenzene

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of lipid synthesis by beta beta'-tetramethyl-substituted, C14-C22, alpha, omega-dicarboxylic acids in cultured rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative extraction of microgram amounts of lipid from cultured human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular mechanisms regulating apoB-containing lipoprotein assembly and secretion in primary hamster hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23118444

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1194/JLR.M030528

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23118444%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23118444%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23118444%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

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