(Q36473486)

14 August 2017

1 reference

title

The role of flavin-containing monooxygenase (FMO) in the metabolism of tamoxifen and other tertiary amines (English)

1 reference

14 August 2017

1 reference

Sharon K Krueger

1

1 reference

14 August 2017

Jonathan E Vandyke

series ordinal

2

1 reference

14 August 2017

David E Williams

series ordinal

3

1 reference

14 August 2017

Ronald N Hines

series ordinal

4

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 January 2006

1 reference

14 August 2017

Drug Metabolism Reviews

1 reference

14 August 2017

38

1 reference

14 August 2017

139-147

1 reference

14 August 2017

1-2

1 reference

Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA.

14 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Structural and catalytic properties of the mammalian flavin-containing monooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Study on the organoleptic intensity scale for measuring oral malodor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Trimethylaminuria and a human FMO3 mutation database

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

CYP2D6-mediated catalysis of tamoxifen aromatic hydroxylation with an NIH shift: similar hydroxylation mechanism in chicken, rat and human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FM03 gene mutations in a Korean population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Genetic polymorphisms of flavin-containing monooxygenase (FMO).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1'-oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

The molecular biology of the flavin-containing monooxygenases of man

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

21 January 2018

The tamoxifen dilemma

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Flavin-containing monooxygenases: catalytic mechanism and substrate specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

An overview of the mechanism, substrate specificities, and structure of FMOs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Tamoxifen metabolism by microsomal cytochrome P450 and flavin-containing monooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Microsomal oxidase. IV. Properties of a mixed-function amine oxidase isolated from pig liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

Hepatic microsomal mixed-function amine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569919

10.1080/03602530600569919

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference