(Q36478837)

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Filarial nematode secreted product ES-62 is an anti-inflammatory agent: therapeutic potential of small molecule derivatives and ES-62 peptide mimetics

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scholarly article

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Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

Filarial nematode secreted product ES-62 is an anti-inflammatory agent: therapeutic potential of small molecule derivatives and ES-62 peptide mimetics (English)

1 reference

Europe PubMed Central

14 August 2017

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author name string

William Harnett

1

1 reference

Europe PubMed Central

14 August 2017

Margaret M Harnett

2

1 reference

Europe PubMed Central

14 August 2017

publication date

1 May 2006

1 reference

Europe PubMed Central

14 August 2017

Clinical and Experimental Pharmacology and Physiology

1 reference

Europe PubMed Central

14 August 2017

33

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Europe PubMed Central

14 August 2017

511-518

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Europe PubMed Central

14 August 2017

5-6

1 reference

Europe PubMed Central

14 August 2017

Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections.

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A worm's eye view of the immune system: consequences for evolution of human autoimmune disease.

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Infections and allergy - helminths, hygiene and host immune regulation

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The dynamics of Wuchereria bancrofti infection: a model-based analysis of longitudinal data from Pondicherry, India

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Transmission intensity and human immune responses to lymphatic filariasis

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Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria

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Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

Induction of signalling anergy via the T-cell receptor in cultured Jurkat T cells by pre-exposure to a filarial nematode secreted product

1 reference

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21 January 2018

In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

Presence of phosphorylcholine on a filarial nematode protein influences immunoglobulin G subclass response to the molecule by an interleukin-10-dependent mechanism

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo.

1 reference

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21 January 2018

Immunotherapy for rheumatoid arthritis

1 reference

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21 January 2018

Role of cytokines in rheumatoid arthritis

1 reference

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21 January 2018

A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

The anti-inflammatory potential of the filarial nematode secreted product, ES-62.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

B cell antigen receptor signaling: roles in cell development and disease.

1 reference

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21 January 2018

Differential signalling during B-cell maturation

1 reference

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21 January 2018

Differential regulation of mRNAs encoding protein kinase C isoenzymes in activated human B cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

A filarial nematode-secreted phosphorylcholine-containing glycoprotein uncouples the B cell antigen receptor from extracellular signal-regulated kinase-mitogen-activated protein kinase by promoting the surface Ig-mediated recruitment of Src homology

1 reference

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Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses

1 reference

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21 January 2018

In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

Proinflammatory cytokines dominate the early immune response to filarial parasites

1 reference

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21 January 2018

Toll-like receptors

1 reference

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Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

1 reference

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Toll-like receptor signalling

1 reference

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

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21 January 2018

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

1 reference

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21 January 2018

Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

Structural/functional aspects of ES-62--a secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1681.2006.04400.X

21 January 2018

Molecular cloning and demonstration of an aminopeptidase activity in a filarial nematode glycoprotein

1 reference

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Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2.

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Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein

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Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells

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C-reactive protein-mediated phagocytosis and phospholipase D signalling through the high-affinity receptor for immunoglobulin G (FcgammaRI).

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Immunomodulatory properties of Ascaris suum glycosphingolipids - phosphorylcholine and non-phosphorylcholine-dependent effects

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Current strategies for the development of peptide-based anti-cancer therapeutics

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Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors

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Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

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Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide.

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Inhibition of the angiogenesis by the MCP-1 (monocyte chemoattractant protein-1) binding peptide

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Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.

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In vivo protein transduction: delivery of a biologically active protein into the mouse

1 reference

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Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo

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Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium

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Origin, kinetics of circulation and fate in vivo of the major excretory-secretory product of Acanthocheilonema viteae

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A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells

1 reference

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Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae

1 reference

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Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: enhanced activity in synovial fluid compared to blood

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Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

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New strategies to control inflammatory synovitis: interleukin 15 and beyond

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Acanthocheilonema viteae: phosphorylcholine is attached to the major excretory-secretory product via an N-linked glycan

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IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells

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IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination

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Is anyone out there listening?

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Identifiers

10.1111/J.1440-1681.2006.04400.X

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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