(Q36483172)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Bojan Bujisic

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Laurent Arthur Decosterd

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Fabio Martinon

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

author name string

Léa Zaffalon

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Antonia Di Micco

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Gianluca Frera

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Rémy Tallant

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

language of work or name

English

0 references

publication date

29 December 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

3 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

volume

113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

page(s)

E117-26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

3 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4720296/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4720296

based on heuristic

inferred from PubMed Central ID database lookup

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A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

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IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis

30 September 2017

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BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates

30 September 2017

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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

30 September 2017

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30 September 2017

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A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity

30 September 2017

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30 September 2017

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Lipid-dependent regulation of the unfolded protein response

30 September 2017

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Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment

30 September 2017

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30 September 2017

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30 September 2017

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Less is more: improving proteostasis by translation slow down

30 September 2017

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Small-Molecule targeting of translation initiation for cancer therapy

30 September 2017

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ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.

30 September 2017

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Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention

30 September 2017

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Pharmacological brake-release of mRNA translation enhances cognitive memory

30 September 2017

1 reference

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

30 September 2017

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Nelfinavir inhibits intra-mitochondrial calcium influx and protects brain against hypoxic-ischemic injury in neonatal mice

30 September 2017

1 reference

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The eIF2α kinases: their structures and functions

30 September 2017

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Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells

30 September 2017

1 reference

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Targeting endoplasmic reticulum signaling pathways in cancer

30 September 2017

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Automatic filtering and substantiation of drug safety signals

30 September 2017

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Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.

30 September 2017

1 reference

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IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

30 September 2017

1 reference

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Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.

30 September 2017

1 reference

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Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals

30 September 2017

1 reference

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Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis

30 September 2017

1 reference

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Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

30 September 2017

1 reference

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Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir

30 September 2017

1 reference

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Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen

30 September 2017

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Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

30 September 2017

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The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

30 September 2017

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Activating transcription factor 4 regulates osteoclast differentiation in mice.

30 September 2017

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The extended PP1 toolkit: designed to create specificity

30 September 2017

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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

30 September 2017

1 reference

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The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis

30 September 2017

1 reference

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Toxicity of HIV protease inhibitors: clinical considerations

30 September 2017

1 reference

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Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

30 September 2017

1 reference

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Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors

30 September 2017

1 reference

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Anti-HIV drugs for cancer therapeutics: back to the future?

30 September 2017

1 reference

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Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis

30 September 2017

1 reference

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30 September 2017

1 reference

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Transcriptional regulation of osteoblasts

30 September 2017

1 reference

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Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

30 September 2017

1 reference

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30 September 2017

1 reference

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Antiretroviral therapy and the human immunodeficiency virus--improved survival but at what cost?

30 September 2017

1 reference

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Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response

30 September 2017

1 reference

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Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review

30 September 2017

1 reference

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XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

30 September 2017

1 reference

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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Peptidomimetic inhibitors of HIV protease

30 September 2017

1 reference

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Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

30 September 2017

All roads lead to ATF4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Stress-induced gene expression requires programmed recovery from translational repression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Gene-specific regulation by general translation factors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Regulated translation initiation controls stress-induced gene expression in mammalian cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Insulin resistance in HIV protease inhibitor-associated diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Intracellular accumulation of nelfinavir and its relationship to P-glycoprotein expression and function in HIV-infected patients.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Using an EGFPmeter to evaluate the lentiviral vector production: tricks and traps

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

High variability of indinavir and nelfinavir pharmacokinetics in HIV-infected patients with a sustained virological response on highly active antiretroviral therapy

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Intracellular measurements of anti-HIV drugs indinavir, amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, efavirenz and nevirapine in peripheral blood mononuclear cells by liquid chromatography coupled to tandem mass spectrometry

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Abnormal body fat distribution and type of antiretroviral therapy as predictors of cardiovascular disease risk in HIV-infected patients

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

Intracellular and plasma pharmacokinetics of nelfinavir and M8 in HIV-infected patients: relationship with P-glycoprotein expression

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4720296

ATF4 regulates lipid metabolism and thermogenesis

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26715744

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1514076113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

26715744

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26715744%20AND%20SRC:MED&resulttype=core&format=json