(Q36484933)

14 August 2017

title

Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment (English)

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14 August 2017

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Douglas G Tilley

1

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14 August 2017

Howard A Rockman

series ordinal

2

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14 August 2017

publication date

1 May 2006

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Expert Review of Cardiovascular Therapy

14 August 2017

published in

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14 August 2017

volume

4

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14 August 2017

issue

3

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14 August 2017

page(s)

417-432

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Tackling the EGFR in pathological tissue remodelling

14 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy

21 January 2018

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Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

21 January 2018

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Cardiovascular drug class specificity: beta-blockers

21 January 2018

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Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

21 January 2018

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Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium

21 January 2018

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Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts

21 January 2018

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Cardiac Gsalpha overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway

21 January 2018

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Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway

21 January 2018

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Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization

21 January 2018

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Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets

21 January 2018

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G-protein-coupled receptor kinase activity in human heart failure: effects of beta-adrenoceptor blockade

21 January 2018

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Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

21 January 2018

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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

21 January 2018

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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

21 January 2018

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Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure

21 January 2018

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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

21 January 2018

1 reference

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RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

21 January 2018

1 reference

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Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

21 January 2018

1 reference

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Matrix metalloproteinase-dependent EGF receptor activation in hypertension and left ventricular hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Signalling by PI3K isoforms: insights from gene-targeted mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Role of phosphoinositide 3-kinase in cardiac function and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14779072.4.3.417

21 January 2018

Identifiers

DOI

10.1586/14779072.4.3.417

1 reference

14 August 2017

1 reference