(Q40395764)

English

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

scientific article published on 19 July 2005

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scholarly article

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31 December 2019

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells (English)

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31 December 2019

Miles D. Houslay

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31 December 2019

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31 December 2019

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Martin J Lynch

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31 December 2019

Ahmed Mohamed

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31 December 2019

Xiang Li

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31 December 2019

Charlotte Maisonneuve

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31 December 2019

Enno Klussmann

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31 December 2019

Gino van Heeke

7

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31 December 2019

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19 July 2005

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31 December 2019

Journal of Biological Chemistry

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31 December 2019

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31 December 2019

33178-33189

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31 December 2019

39

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31 December 2019

Localized effects of cAMP mediated by distinct routes of protein kinase A.

1 reference

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21 January 2018

Cyclic nucleotide research -- still expanding after half a century

1 reference

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21 January 2018

AKAP mediated signal transduction

1 reference

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21 January 2018

cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases

1 reference

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21 January 2018

Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes

1 reference

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21 January 2018

Novel single chain cAMP sensors for receptor-induced signal propagation.

1 reference

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21 January 2018

Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering

1 reference

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21 January 2018

Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.

1 reference

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21 January 2018

Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system

1 reference

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21 January 2018

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

1 reference

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21 January 2018

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

1 reference

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21 January 2018

Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4).

1 reference

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21 January 2018

Theophylline and PDE4 inhibitors in asthma.

1 reference

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21 January 2018

New phosphodiesterase inhibitors as therapeutics for the treatment of chronic lung disease

1 reference

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21 January 2018

Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D

1 reference

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21 January 2018

Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses

1 reference

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21 January 2018

PDE4D plays a critical role in the control of airway smooth muscle contraction

1 reference

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21 January 2018

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation

1 reference

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21 January 2018

Seven-transmembrane receptors

1 reference

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21 January 2018

Characterization of G protein-coupled receptor kinases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Roles of G-protein-coupled receptor dimerization

1 reference

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21 January 2018

Arresting developments in heptahelical receptor signaling and regulation

1 reference

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21 January 2018

The ins and outs of G protein-coupled receptor trafficking

1 reference

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21 January 2018

Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.

1 reference

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21 January 2018

beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation

1 reference

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21 January 2018

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling

1 reference

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21 January 2018

Ligand regulation of green fluorescent protein-tagged forms of the human beta(1)- and beta(2)-adrenoceptors; comparisons with the unmodified receptors

1 reference

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21 January 2018

Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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21 January 2018

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

1 reference

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21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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21 January 2018

The ins and outs of RNAi in mammalian cells

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21 January 2018

siRNA for gene silencing: a route to drug target discovery

1 reference

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21 January 2018

Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes

1 reference

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21 January 2018

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

1 reference

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21 January 2018

Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414316200

21 January 2018

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

1 reference

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21 January 2018

The molecular basis for protein kinase A anchoring revealed by solution NMR

1 reference

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21 January 2018

Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility

1 reference

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21 January 2018

Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling

1 reference

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21 January 2018

Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization

1 reference

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21 January 2018

Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor

1 reference

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21 January 2018

Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

1 reference

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21 January 2018

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

1 reference

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21 January 2018

Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs

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Identifiers

10.1074/JBC.M414316200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16030021%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference

Europe PubMed Central

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31 December 2019

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