(Q36485655)

14 August 2017

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title

Signalling mechanisms linking hepatic glucose and lipid metabolism (English)

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14 August 2017

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M O Weickert

1

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PubMed ID

16718463

14 August 2017

A F H Pfeiffer

series ordinal

2

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14 August 2017

23 May 2006

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14 August 2017

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14 August 2017

49

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14 August 2017

8

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14 August 2017

1732-1741

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https://scigraph.springernature.com/pub.10.1007/s00125-006-0295-3

14 August 2017

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cites work

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https://api.crossref.org/works/10.1007%2FS00125-006-0295-3

ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

21 January 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

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Novel concepts in insulin regulation of hepatic gluconeogenesis

21 January 2018

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Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

21 January 2018

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

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12 December 2020

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

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12 December 2020

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

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12 December 2020

Adiponectin and protection against type 2 diabetes mellitus

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12 December 2020

AMP-activated protein kinase: balancing the scales.

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12 December 2020

Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity

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12 December 2020

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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12 December 2020

Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice

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12 December 2020

Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.

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12 December 2020

Role of stearoyl-coenzyme A desaturase in lipid metabolism

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12 December 2020

Analysis of the role of protein kinase B (cAKT) in insulin-dependent induction of glucokinase and sterol regulatory element-binding protein 1 (SREBP1) mRNAs in hepatocytes

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12 December 2020

Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis

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12 December 2020

PPAR Tissue Distribution and Interactions with Other Hormone-Signaling Pathways

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12 December 2020

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

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12 December 2020

Insulin-regulated gene expression

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12 December 2020

Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients.

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12 December 2020

Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.

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12 December 2020

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

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12 December 2020

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

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12 December 2020

Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system

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12 December 2020

Roles of PPARs in health and disease.

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12 December 2020

Does central obesity reflect "Cushing's disease of the omentum"?

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12 December 2020

Hepatic glucose metabolism in humans--its role in health and disease

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12 December 2020

Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver

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12 December 2020

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

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12 December 2020

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

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12 December 2020

Transcriptional repression of atherogenic inflammation: modulation by PPARdelta

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12 December 2020

Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice

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12 December 2020

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

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12 December 2020

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

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12 December 2020

Nonalcoholic fatty liver disease

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12 December 2020

Hepatocarcinogenesis of peroxisome proliferators

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12 December 2020

Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes

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12 December 2020

Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.

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12 December 2020

Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid beta-oxidation

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12 December 2020

Malonyl-CoA, fuel sensing, and insulin resistance

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12 December 2020

A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis

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12 December 2020

Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers

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12 December 2020

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

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12 December 2020

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

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12 December 2020

Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes

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12 December 2020

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

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12 December 2020

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

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12 December 2020

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

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12 December 2020

Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis

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12 December 2020

Fatty acid regulation of hepatic gene transcription.

1 reference

12 December 2020

Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice

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12 December 2020

The Endocrine Effects of Long-Term Treatment with Mifepristone (RU 486)

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12 December 2020

Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta

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12 December 2020

Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue

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12 December 2020

Regulation of glucose production by the liver

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12 December 2020

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

1 reference

12 December 2020

Insulin acutely decreases hepatic fatty acid synthase activity

1 reference

12 December 2020

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

1 reference

12 December 2020

Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha

1 reference

12 December 2020

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids

1 reference

12 December 2020

Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice

1 reference

12 December 2020

Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver.

1 reference

12 December 2020

Rosiglitazone in the treatment of HAART-associated lipodystrophy--a randomized double-blind placebo-controlled study.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

1 reference

12 December 2020

A brain-liver circuit regulates glucose homeostasis

1 reference

12 December 2020

A high-cholesterol, n-3 polyunsaturated fatty acid diet causes different responses in rats and hamsters.

1 reference

12 December 2020

Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.

1 reference

12 December 2020

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

12 December 2020

Re-emergence of fibrates in the management of dyslipidemia and cardiovascular risk

1 reference

12 December 2020

Modulation of carbohydrate response element-binding protein gene expression in 3T3-L1 adipocytes and rat adipose tissue.

1 reference

12 December 2020

Old fat, make way for new fat.

1 reference

12 December 2020

Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

1 reference

12 December 2020

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

1 reference

12 December 2020

SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.

1 reference

12 December 2020

Therapeutic roles of peroxisome proliferator-activated receptor agonists

1 reference

12 December 2020

Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

1 reference

12 December 2020

Management of cellular energy by the AMP-activated protein kinase system

1 reference

12 December 2020

Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription

1 reference

12 December 2020

Putative metabolic effects of the liver X receptor (LXR).

1 reference

12 December 2020

Glucose regulation of gene transcription

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12 December 2020

Effects of free fatty acids on gluconeogenesis and glycogenolysis

1 reference

12 December 2020

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

1 reference

12 December 2020

Pharmacotherapy for dyslipidaemia – current therapies and future agents

1 reference

12 December 2020

Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes

1 reference

12 December 2020

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

1 reference

12 December 2020

Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells.

1 reference

12 December 2020

The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling

1 reference

12 December 2020

Synergistic induction of apoptosis with glucocorticoids and 3',5'-cyclic adenosine monophosphate reveals agonist activity by RU 486.

1 reference

12 December 2020

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

1 reference

12 December 2020

SREBPs suppress IRS-2-mediated insulin signalling in the liver.

1 reference

12 December 2020

Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms

1 reference

12 December 2020

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

1 reference

12 December 2020

Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C

1 reference

12 December 2020

PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.

1 reference

12 December 2020

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

1 reference

12 December 2020

Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

1 reference

12 December 2020

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

1 reference

12 December 2020

The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression

1 reference

12 December 2020

Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion

1 reference

12 December 2020

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

1 reference

12 December 2020

Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase

1 reference

12 December 2020

Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage

1 reference

12 December 2020

Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes

1 reference

12 December 2020

New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

1 reference

12 December 2020

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

1 reference

12 December 2020

Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.

1 reference

12 December 2020

Molecular mediators of hepatic steatosis and liver injury

1 reference

12 December 2020

The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

1 reference

12 December 2020

LXRs regulate the balance between fat storage and oxidation.

1 reference

12 December 2020

Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio

1 reference

12 December 2020

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

1 reference

12 December 2020

Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study

1 reference

12 December 2020

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

1 reference

12 December 2020

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

1 reference

12 December 2020

Regulation of blood glucose by hypothalamic pyruvate metabolism

1 reference

12 December 2020

10.1007/S00125-006-0295-3

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16718463