(Q36488747)

14 August 2017

title

Validating cancer drug targets (English)

1 reference

14 August 2017

John D Benson

1

1 reference

14 August 2017

Ying-Nan P Chen

2

1 reference

14 August 2017

Susan A Cornell-Kennon

3

1 reference

14 August 2017

Marion Dorsch

4

1 reference

14 August 2017

Sunkyu Kim

5

1 reference

14 August 2017

Magdalena Leszczyniecka

6

1 reference

14 August 2017

William R Sellers

7

1 reference

14 August 2017

Christoph Lengauer

8

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 May 2006

1 reference

14 August 2017

1 reference

14 August 2017

volume

441

1 reference

14 August 2017

issue

7092

1 reference

14 August 2017

page(s)

451-456

1 reference

https://scigraph.springernature.com/pub.10.1038/nature04873

14 August 2017

exact match

0 references

cites work

The development of imatinib as a therapeutic agent for chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Cancer. Addiction to oncogenes--the Achilles heal of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Integrating genetic approaches into the discovery of anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

The concept of synthetic lethality in the context of anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Retinoid target genes in acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Cancer. Encouraging results for second-generation antiangiogenesis drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Raf: a strategic target for therapeutic development against cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

High frequency of BRAF mutations in nevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Measurement of a linear free energy relationship one molecule at a time

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Erlotinib in lung cancer - molecular and clinical predictors of outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Targeting non-small cell lung cancer with epidermal growth factor tyrosine kinase inhibitors: where do we stand, where do we go.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Isolation of a transforming sequence from a human bladder carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Use of isogenic human cancer cells for high-throughput screening and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Using Drosophila melanogaster to map human cancer pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Zebrafish as a cancer model system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Yeast as a model system for anticancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

What's wrong with our cancer models?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Target selection issues in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

The PIK3CA gene is mutated with high frequency in human breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Cancer drug discovery through collaboration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Roles of stem cell factor/c-Kit and effects of Glivec/STI571 in human uveal melanoma cell tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

The Akt pathway: molecular targets for anti-cancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Fine allelotyping of Erbb2-induced mammary tumors in mice reveals multiple discontinuous candidate regions of tumor-suppressor loci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

An in vitro study on the suppressive effect of glioma cell growth induced by plasmid-based small interference RNA (siRNA) targeting human epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Transgenic expression of PML/RARalpha impairs myelopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Comparative analysis of genes regulated by PML/RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Expression of estrogen receptor alpha, retinoic acid receptor alpha and cellular retinoic acid binding protein II genes is coordinately regulated in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Induction of aromatase expression in cervical carcinomas: effects of endogenous estrogen on cervical cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Inhibiting the growth of malignant melanoma by blocking the expression of vascular endothelial growth factor using an RNA interference approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

Early events in leukemogenesis in P190Bcr-abl transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04873

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE04873

1 reference

Dimensions Publication ID

14 August 2017

1040010450

0 references

1 reference