(Q28268061)

Global mapping of the yeast genetic interaction network

21 April 2017

1 reference

Proliferation, cell cycle and apoptosis in cancer

21 April 2017

1 reference

Hsp90 as a capacitor for morphological evolution

21 April 2017

1 reference

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

21 April 2017

1 reference

Cdk2 knockout mice are viable

21 April 2017

1 reference

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

21 April 2017

1 reference

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 April 2017

1 reference

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 April 2017

1 reference

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

21 April 2017

1 reference

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 April 2017

1 reference

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

21 April 2017

1 reference

Establishment of a chemical synthetic lethality screen in cultured human cells

21 April 2017

1 reference

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

21 April 2017

1 reference

Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library

21 April 2017

1 reference

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 April 2017

1 reference

A system for stable expression of short interfering RNAs in mammalian cells

21 April 2017

1 reference

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

21 April 2017

1 reference

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

21 April 2017

1 reference

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

21 April 2017

1 reference

Protein degradation and protection against misfolded or damaged proteins

21 April 2017

1 reference

Cancer. Addiction to oncogenes--the Achilles heal of cancer

21 April 2017

1 reference

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

21 April 2017

1 reference

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

21 April 2017

1 reference

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 April 2017

1 reference

Choosing anticancer drug targets in the postgenomic era.

21 April 2017

1 reference

Using cancer genetics to guide the selection of anticancer drug targets

31 March 2020

1 reference

Gleevec: prototype or outlier?

31 March 2020

1 reference

Principles for the buffering of genetic variation

31 March 2020

1 reference

Synthetic enhancement in gene interaction: a genetic tool come of age.

31 March 2020

1 reference

Mutation load, functional overlap, and synthetic lethality in the evolution and treatment of cancer

31 March 2020

1 reference

Emerging uses for genomic information in drug discovery

31 March 2020

1 reference

From large networks to small molecules

31 March 2020

1 reference

Synthetic dosage lethality

31 March 2020

1 reference

Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system

31 March 2020

1 reference

Integrating genetic approaches into the discovery of anticancer drugs

31 March 2020

1 reference

Role of the retinoblastoma protein in the pathogenesis of human cancer

31 March 2020

1 reference

E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis

31 March 2020

1 reference

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

31 March 2020

1 reference

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

31 March 2020

1 reference

Chemosensitivity linked to p73 function

31 March 2020

1 reference

Heat shock protein 90 as a molecular target for cancer therapeutics

31 March 2020

1 reference

Altered states: selectively drugging the Hsp90 cancer chaperone

31 March 2020

1 reference

Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update

31 March 2020

1 reference

Proteasome inhibition as a novel therapeutic target in human cancer.

31 March 2020

1 reference

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

31 March 2020

1 reference

Differential regulation of E2F transactivation by cyclin/cdk2 complexes

31 March 2020

1 reference

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation

31 March 2020

1 reference

Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector.

31 March 2020

1 reference

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

31 March 2020

1 reference

Proteasome-mediated destruction of the cyclin a/cyclin-dependent kinase 2 complex suppresses tumor cell growth in vitro and in vivo

31 March 2020

1 reference

Proliferation of cancer cells despite CDK2 inhibition.

31 March 2020

1 reference

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

31 March 2020

1 reference

Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells

31 March 2020

1 reference

The synthesis of protein(S) for chromosome condensation may be regulated by a post-transcriptional mechanism

31 March 2020

1 reference

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

31 March 2020

1 reference

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

31 March 2020

1 reference

Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis

31 March 2020

1 reference

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

31 March 2020

1 reference

Consequences of nonadaptive alterations in cancer

31 March 2020

1 reference

Gene deletion: a new target for cancer chemotherapy

31 March 2020

1 reference

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

31 March 2020

1 reference

Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells.

31 March 2020

1 reference

Combining biological networks to predict genetic interactions

31 March 2020

1 reference

Use of isogenic human cancer cells for high-throughput screening and drug discovery

31 March 2020

1 reference

Genetic synthetic lethality screen at the single gene level in cultured human cells

31 March 2020

1 reference

F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell

31 March 2020

1 reference

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

31 March 2020

1 reference

Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

31 March 2020

1 reference

Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations

31 March 2020

1 reference

Systematic discovery of multicomponent therapeutics

31 March 2020

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

1 reference

Drug-like properties and the causes of poor solubility and poor permeability

31 March 2020

1 reference

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

31 March 2020

1 reference

Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription

31 March 2020

1 reference

Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action

31 March 2020

1 reference

Genomic profiling of drug sensitivities via induced haploinsufficiency.

31 March 2020

1 reference

Drug target validation and identification of secondary drug target effects using DNA microarrays

31 March 2020

1 reference

lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.

31 March 2020

1 reference

lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans

31 March 2020

1 reference

fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen

31 March 2020

1 reference

Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene

31 March 2020

1 reference

Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition

31 March 2020

1 reference

RNAi and HTS: exploring cancer by systematic loss-of-function

31 March 2020

1 reference

Stable suppression of tumorigenicity by virus-mediated RNA interference

31 March 2020

1 reference

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

31 March 2020

1 reference

A resource for large-scale RNA-interference-based screens in mammals.

31 March 2020

1 reference

Enzymatic production of RNAi libraries from cDNAs.

31 March 2020

1 reference

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

31 March 2020

1 reference

Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

31 March 2020

1 reference

Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens.

31 March 2020

1 reference

RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells.

31 March 2020

1 reference

DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray

31 March 2020

1 reference

Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy

31 March 2020

1 reference

Characterization of synthetic DNA bar codes in Saccharomyces cerevisiae gene-deletion strains

31 March 2020

1 reference

Simultaneous identification of bacterial virulence genes by negative selection.

31 March 2020

1 reference