(Q36495172)

14 August 2017

1 reference

title

Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis (English)

1 reference

14 August 2017

Ulrich Beuers

1

1 reference

PubMed ID

16741551

14 August 2017

language of work or name

English

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publication date

1 June 2006

1 reference

Nature Reviews Gastroenterology & Hepatology

14 August 2017

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14 August 2017

3

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14 August 2017

318-328

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14 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/ncpgasthep0521

14 August 2017

0 references

cites work

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21 January 2018

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Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'.

21 January 2018

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Ursodeoxycholic acid for primary biliary cirrhosis: lessons from the past--issues for the future

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21 January 2018

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Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid

21 January 2018

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Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy

21 January 2018

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Bile salt transporters: molecular characterization, function, and regulation

21 January 2018

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Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis

21 January 2018

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Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver

21 January 2018

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Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver

21 January 2018

1 reference

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Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats

21 January 2018

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Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver

21 January 2018

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Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase

21 January 2018

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Role of vesicle-mediated transport pathways in hepatocellular bile secretion

21 January 2018

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Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis

21 January 2018

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Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes

21 January 2018

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Signal transduction and hepatocellular bile acid transport: cross talk between bile acids and second messengers

21 January 2018

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Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways

21 January 2018

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Ca2+-dependent protein kinase C isoforms induce cholestasis in rat liver

21 January 2018

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Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets

21 January 2018

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Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis

21 January 2018

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Characterization of the mouse bile salt export pump overexpressed in the baculovirus system

21 January 2018

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Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.

21 January 2018

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Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation

21 January 2018

1 reference

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Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes

21 January 2018

1 reference

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Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner

21 January 2018

1 reference

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Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways

21 January 2018

1 reference

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Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes

21 January 2018

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Oncosis represents the main type of cell death in mouse models of cholestasis

21 January 2018

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Cholestatic hepatocellular injury: what do we know and how should we proceed.

21 January 2018

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Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

21 January 2018

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Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

21 January 2018

1 reference

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No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

Ursodeoxycholic acid induced activation of the glucocorticoid receptor in primary rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

Effect of high-dose ursodeoxycholic acid on its biliary enrichment in primary sclerosing cholangitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha

21 January 2018

1 reference

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Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT test

21 January 2018

1 reference

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Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

Inappropriate ileal conservation of bile acids in cholestatic liver disease: homeostasis gone awry

21 January 2018

1 reference

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Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis

21 January 2018

1 reference

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Formation of iso-ursodeoxycholic acid during administration of ursodeoxycholic acid in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

Bile acid structure and selective modulation of murine hepatic cytochrome P450-linked enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

Bile acids with differing hydrophilic-hydrophobic properties do not influence cytokine production by human monocytes and murine Kupffer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

Pharmacology of ursodeoxycholic acid, an enterohepatic drug.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Treatment of primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Influence of cholestasis on absorption of ursodeoxycholic acid

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid.

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Biliary transport systems: short-term regulation

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Relationship between biliary and serum bile acids and response to ursodeoxycholic acid in patients with primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene.

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Assessment of biliary bicarbonate secretion in humans by positron emission tomography

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effect of ursodeoxycholic acid on the kinetics of cholic acid and chenodeoxycholic acid in patients with primary sclerosing cholangitis

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Immunomodulatory effects of ursodeoxycholic acid on immune responses

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Identifiers

DOI

10.1038/NCPGASTHEP0521

1 reference

14 August 2017

1 reference

PubMed ID

16741551