(Q36499242)

14 August 2017

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title

Interferon regulatory factor-5-regulated pathways as a target for colorectal cancer therapeutics (English)

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14 August 2017

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Goudong Hu

1

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14 August 2017

Betsy J Barnes

series ordinal

2

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14 August 2017

publication date

1 May 2006

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Expert Review of Anticancer Therapy

14 August 2017

published in

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14 August 2017

volume

6

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14 August 2017

issue

5

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14 August 2017

page(s)

775-784

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14 August 2017

cites work

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Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

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New anticancer agents and therapeutic strategies in development for solid cancers: a clinical perspective

21 January 2018

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Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

21 January 2018

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The growing family of interferon regulatory factors

21 January 2018

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Interferon regulatory factors: the next generation

21 January 2018

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The role of interferon regulatory factors in the interferon system and cell growth control

21 January 2018

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On the role of IRF in host defense

21 January 2018

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Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

21 January 2018

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Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway

21 January 2018

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Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53.

21 January 2018

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Signaling through IFN regulatory factor-5 sensitizes p53-deficient tumors to DNA damage-induced apoptosis and cell death

21 January 2018

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

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An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes

21 January 2018

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Human beta-interferon gene expression is regulated by an inducible enhancer element.

21 January 2018

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Overlapping positive and negative regulatory domains of the human beta-interferon gene

21 January 2018

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Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences

21 January 2018

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IRF family of transcription factors as regulators of host defense

21 January 2018

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Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes

21 January 2018

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Control of IRF-3 activation by phosphorylation

21 January 2018

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Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation

21 January 2018

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Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis

21 January 2018

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Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes

21 January 2018

1 reference

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Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.

21 January 2018

1 reference

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Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways

21 January 2018

1 reference

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Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells

21 January 2018

1 reference

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Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes

21 January 2018

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Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection

21 January 2018

1 reference

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Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function

21 January 2018

1 reference

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The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32

21 January 2018

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RNA processing and human disease

21 January 2018

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Splicing regulation as a potential genetic modifier

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Potential methods to circumvent blocks in apoptosis in lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Complementation of the radiosensitive M059J cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Death receptors: signaling and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Apoptotic pathways: paper wraps stone blunts scissors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

The potential of TRAIL for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

A mechanism of resistance to TRAIL/Apo2L-induced apoptosis of newly established glioma cell line and sensitisation to TRAIL by genotoxic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

The promise of genetically engineered mice for cancer prevention studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.5.775

21 January 2018

Identifiers

DOI

10.1586/14737140.6.5.775

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14 August 2017

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