(Q36500552)

14 August 2017

1 reference

title

Targeting cellular FLICE-like inhibitory protein as a novel approach to the treatment of Hodgkin's lymphoma (English)

1 reference

14 August 2017

Amanda Dutton

1

1 reference

14 August 2017

Alan T H Burns

series ordinal

2

1 reference

14 August 2017

Lawrence S Young

series ordinal

3

1 reference

14 August 2017

Paul G Murray

series ordinal

4

1 reference

14 August 2017

1 June 2006

1 reference

Expert Review of Anticancer Therapy

14 August 2017

1 reference

14 August 2017

6

1 reference

14 August 2017

911-919

1 reference

14 August 2017

6

1 reference

Long-term survival and competing causes of death in patients with early-stage Hodgkin's disease treated at age 50 or younger

14 August 2017

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Treatment of unfavorable childhood Hodgkin's disease with VEPA and low-dose, involved-field radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

CD40 and its ligand: central players in B lymphocyte survival, growth, and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Death-receptor contribution to the germinal-center reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Cultivated H-RS cells are resistant to CD95L-mediated apoptosis despite expression of wild-type CD95.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Caspase activation: revisiting the induced proximity model

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

A unified model for apical caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Insights into the regulatory mechanism for caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Nature's TRAIL--on a path to cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Targeting death receptors in cancer with Apo2L/TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Death to the bad guys: targeting cancer via Apo2L/TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Targeting death receptors in bladder, prostate and renal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Inhibition of death receptor signals by cellular FLIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Casper is a FADD- and caspase-related inducer of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

CASH, a novel caspase homologue with death effector domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

c-FLIPR, a new regulator of death receptor-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

The role of c-FLIP in modulation of CD95-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Activation of caspases-8 and -10 by FLIP(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Low frequency of FAS mutations in Reed-Sternberg cells of Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

NF-kappaB signals induce the expression of c-FLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Activation of NF-kappaB by FADD, Casper, and caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Activation of the NF-kappaB pathway by caspase 8 and its homologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

An essential role for c-FLIP in the efficient development of mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

RNA interference and potential therapeutic applications of short interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

21 January 2018

Fatigue in primary care

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

FLIP protects cardiomyocytes from apoptosis induced by simulated ischemia/reoxygenation, as demonstrated by short hairpin-induced (shRNA) silencing of FLIP mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

cFLIP regulation of lymphocyte activation and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

The restricted expression pattern of the Hodgkin's lymphoma-associated cytokine receptor CD30 is regulated by a minimal promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

THE ORIGIN OF HODGKIN AND REED/STERNBERG CELLS IN HODGKIN'S DISEASE

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.6.911

21 January 2018

Identifiers

DOI

10.1586/14737140.6.6.911

1 reference

14 August 2017

1 reference