(Q36526351)

14 August 2017

1 reference

title

Immune mechanisms and therapeutic potential of CpG oligodeoxynucleotides (English)

1 reference

14 August 2017

5

Lorne A Babiuk

1 reference

14 August 2017

6

George K Mutwiri

1 reference

14 August 2017

2

Arshud Dar

1 reference

14 August 2017

3

Scott K Napper

1 reference

14 August 2017

Heather L Wilson

1

1 reference

PubMed ID

16818371

14 August 2017

A Marianela Lopez

series ordinal

4

1 reference

14 August 2017

1 May 2006

1 reference

International Reviews of Immunology

14 August 2017

1 reference

14 August 2017

25

1 reference

14 August 2017

183-213

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14 August 2017

3-4

1 reference

CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity

14 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG-DNA protects against a lethal orthopoxvirus infection in a murine model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

The immunogenicity and protective efficacy of bovine herpesvirus 1 glycoprotein D plus Emulsigen are increased by formulation with CpG oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Immunostimulatory oligonucleotides in therapy of allergic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

From bugs to drugs: therapeutic immunomodulation with oligodeoxynucleotides containing CpG sequences from bacterial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Drosophila Toll and IL-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

A family of human receptors structurally related to Drosophila Toll

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Pathogen recognition: TLRs throw us a curve

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Bacterial LPS and CpG DNA differentially induce gene expression profiles in mouse macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Bovine toll-like receptor 9: a comparative analysis of molecular structure, function and expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

A Toll-like receptor recognizes bacterial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG-rich islands and the function of DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG motifs in bacterial DNA and their immune effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG motifs in bacterial DNA trigger direct B-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Poly-guanosine motifs costimulate antigen-reactive CD8 T cells while bacterial CpG-DNA affect T-cell activation via antigen-presenting cell-derived cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Necessity of oligonucleotide aggregation for toll-like receptor 9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Phosphorothioate backbone modification modulates macrophage activation by CpG DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

A novel function of phosphorothioate oligodeoxynucleotides as chemoattractants for primary macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Multiple mechanisms may contribute to the cellular anti-adhesive effects of phosphorothioate oligodeoxynucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG DNA and LPS induce distinct patterns of activation in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG DNA: recognition by and activation of monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Functional responses of human neonatal B lymphocytes to antigen receptor cross-linking and CpG DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Mechanisms and therapeutic applications of immune stimulatory cpG DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

A novel transcription factor, T-bet, directs Th1 lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Immunostimulatory DNA sequences necessary for effective intradermal gene immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Identification of the molecular mechanism by which TLR ligation and IFN-gamma synergize to induce MIG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Bacterial DNA as immune cell activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Use of CpG oligodeoxynucleotides as immunoprotective agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Type I interferon-mediated stimulation of T cells by CpG DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Monocytes are required for optimum in vitro stimulation of bovine peripheral blood mononuclear cells by non-methylated CpG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Natural killer cells in antiviral defense: function and regulation by innate cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Biodistribution and metabolism of immunostimulatory oligodeoxynucleotide CPG 7909 in mouse and rat tissues following subcutaneous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

In vivo immunostimulatory effects of CpG oligodeoxynucleotide in cattle and sheep

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG oligodeoxynucleotides enhance host defense during murine tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Prevention and treatment of cutaneous leishmaniasis in primates by using synthetic type D/A oligodeoxynucleotides expressing CpG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Protection of chickens against Escherichia coli infections by DNA containing CpG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

In vitro activation of chicken leukocytes and in vivo protection against Salmonella enteritidis organ invasion and peritoneal S. enteritidis infection-induced mortality in neonatal chickens by immunostimulatory CpG oligodeoxynucleotide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Contribution of nitric oxide to CpG-mediated protection against Listeria monocytogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG oligodeoxynucleotides increase the susceptibility of normal mice to infection by Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

A comparison of biodegradable microparticles and MF59 as systemic adjuvants for recombinant gD from HSV-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG-containing oligodeoxynucleotides, in combination with conventional adjuvants, enhance the magnitude and change the bias of the immune responses to a herpesvirus glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Antigen-immunostimulatory oligonucleotide conjugates: mechanisms and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Immunostimulatory DNA Inhibits Transforming Growth Factor-β Expression and Airway Remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Immunostimulatory DNA reverses established allergen-induced airway remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

DNA-based immunotherapeutics for the treatment of allergic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Inhibition of experimental asthma by indoleamine 2,3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Antisense c-myc and immunostimulatory oligonucleotide inhibition of tumorigenesis in a murine B-cell lymphoma transplant model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Successful combination of local CpG-ODN and radiotherapy in malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Contrasting activity of cytosin–guanosin dinucleotide oligonucleotides in mice with experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Neonatal and early life vaccinology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a Th2-biased pattern which persists after adult boosting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Co-administration of porcine-specific CpG oligodeoxynucleotide enhances the immune responses to pseudorabies attenuated virus vaccine in newborn piglets in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

CpG oligodeoxynucleotides stimulate cord blood mononuclear cells to produce immunoglobulins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

DNA vaccines: safety and efficacy issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Safety of CpG oligodeoxynucleotides in veterinary species

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Induction of immune-mediated glomerulonephritis in normal mice immunized with bacterial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB x NZWF1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Toll-like receptor 9 signaling protects against murine lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4+CD62L+ T cells which prevent intestinal inflammation in the SCID transfer model of colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180600785868

10.1080/08830180600785868

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16818371