(Q36534381)

English

Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease

scientific article published on 19 October 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

sickle-cell disease

0 references

Athar H Chishti

8

object named as

Athar H Chishti

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

author name string

Lucia De Franceschi

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Robert S Franco

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Mariarita Bertoldi

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Carlo Brugnara

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Alessandro Matté

5

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Angela Siciliano

6

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Adam J Wieschhaus

7

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Clinton H Joiner

9

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

0 references

publication date

19 October 2012

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

27

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

750-759

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in β-thalassemic erythropoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Calpain cleavage prediction using multiple kernel learning.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Thrombosis and sickle cell disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Adhesion of sickle red cells to endothelium: myths and future directions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Urea stimulation of KCl cotransport induces abnormal volume reduction in sickle reticulocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Oxidative stress-dependent structural and functional switching of a human 2-Cys peroxiredoxin isotype II that enhances HeLa cell resistance to H2O2-induced cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Peroxynitrite induces senescence and apoptosis of red blood cells through the activation of aspartyl and cysteinyl proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Established and experimental treatments for sickle cell disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Trafficking of the Ca2+-activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

ATP-dependent activation of the intermediate conductance, Ca2+-activated K+ channel, hIK1, is conferred by a C-terminal domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Structure and physiological function of calpains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Calpain: new perspectives in molecular diversity and physiological-pathological involvement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

Sickle cell hemoglobin polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

The calmodulin-binding site of the plasma membrane Ca2+ pump interacts with the transduction domain of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

30 September 2017

The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

28 June 2018

KCl cotransport mediates abnormal sulfhydryl-dependent volume regulation in sickle reticulocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

28 June 2018

Molecular and functional properties of a calpain activator protein specific for mu-isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

28 June 2018

Calpromotin, a cytoplasmic protein, is associated with the formation of dense cells in sickle cell anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

28 June 2018

Site-directed activation of calpain is promoted by a membrane-associated natural activator protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

28 June 2018

Reconstitution of Ca(2+)-dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

28 June 2018

Heat-shock protein-27, -70 and peroxiredoxin-II show molecular chaperone function in sickle red cells: Evidence from transgenic sickle cell mouse model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

Phosphotyrosine phosphatases acting on band 3 in human erythrocytes of different age: PTP1B processing during cell ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

Calpain inhibitors, a treatment for Alzheimer's disease: position paper

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

The CXC motif: a functional mimic of protein disulfide isomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

Phosphatidylserine externalization in sickle red blood cells: associations with cell age, density, and hemoglobin F.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

Regulation of thioredoxin peroxidase activity by C-terminal truncation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

Modulation of endothelial cell activation in sickle cell disease: a pilot study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

Phorbol 12-myristate 13-acetate-stimulated phosphorylation of erythrocyte membrane skeletal proteins is blocked by calpain inhibitors: possible role of protein kinase M.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

Sulfhydryl oxidation and activation of red cell K(+)-Cl- cotransport in the transgenic SAD mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

Comparative action of calpain on erythrocyte Ca2(+)-pumping ATPase in sickle cell anaemia, essential hypertension and kwashiorkor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

21 September 2018

Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease-specific lung injury induced by hypoxia/reoxygenation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545531

4 December 2018

Endothelins activate Ca(2+)-gated K(+) channels via endothelin B receptors in CD-1 mouse erythrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties and intracellular localization of calpain activator protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of calpain in the selective increased phosphorylation of the anion-transport protein in red cell of hypertensive subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dehydration of mature and immature sickle red blood cells during fast oxygenation/deoxygenation cycles: role of KCl cotransport and extracellular calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calmodulin regulates assembly and trafficking of SK4/IK1 Ca2+-activated K+ channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acid pH induces formation of dense cells in sickle erythrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of Gardos channel activity by cytokines in sickle erythrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The survival characteristics of dense sickle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro digestion of spectrin, protein 4.1 and ankyrin by erythrocyte calcium dependent neutral protease (calpain I)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PKC alpha activation on Ca2+ pump and K(Ca) channel in deoxygenated sickle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain I activates Ca2+ transport by the reconstituted erythrocyte Ca2+ pump

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23085996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1096/FJ.12-217836

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

0 references

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