(Q36547252)

14 August 2017

Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice (English)

1 reference

14 August 2017

0 references

1 reference

1 reference

25

1 reference

14 August 2017

Kristen T Rooney

15

0 references

Monica P Goldklang

Monica P Goldklang

17

0 references

Francesca Polverino

Francesca Polverino

8

0 references

Suzanne M Cloonan

Suzanne M Cloonan

1

0 references

Kimberly Glass

2

Kimberly Glass

1 reference

14 August 2017

Jeanine M. D'Armiento

22

Jeanine M D'Armiento

1 reference

14 August 2017

11

Kenji Mizumura

1 reference

14 August 2017

29

Augustine M K Choi

1 reference

14 August 2017

Maria E Laucho-Contreras

3

1 reference

14 August 2017

Abhiram R Bhashyam

4

1 reference

14 August 2017

Morgan Cervo

5

1 reference

14 August 2017

Maria A Pabón

6

1 reference

14 August 2017

Csaba Konrad

7

1 reference

14 August 2017

Ilias I Siempos

9

1 reference

14 August 2017

Elizabeth Perez

10

1 reference

14 August 2017

Manik C Ghosh

12

1 reference

14 August 2017

Harikrishnan Parameswaran

13

1 reference

14 August 2017

Niamh C Williams

14

1 reference

14 August 2017

Zhi-Hua Chen

16

1 reference

14 August 2017

Guo-Cheng Yuan

18

1 reference

14 August 2017

Stephen C Moore

19

1 reference

14 August 2017

Dawn L Demeo

20

1 reference

14 August 2017

Tracey A Rouault

21

1 reference

14 August 2017

Eric A Schon

23

1 reference

14 August 2017

Giovanni Manfredi

24

1 reference

14 August 2017

Ashfaq Mahmood

26

1 reference

14 August 2017

Edwin K Silverman

27

1 reference

14 August 2017

Caroline A Owen

28

1 reference

14 August 2017

language of work or name

English

0 references

publication date

11 January 2016

1 reference

14 August 2017

12

1 reference

inferred from page(s)

published in

Nature Medicine

1 reference

14 August 2017

22

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14 August 2017

2

1 reference

14 August 2017

163-174

1 reference

describes a project that uses

14 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4742374/fullTextXML

inferred from PubMed Central ID database lookup

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Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice

30 September 2017

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Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci

30 September 2017

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IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease

30 September 2017

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Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

30 September 2017

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Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease

30 September 2017

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30 September 2017

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30 September 2017

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Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

30 September 2017

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30 September 2017

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hCOA3 stabilizes cytochrome c oxidase 1 (COX1) and promotes cytochrome c oxidase assembly in human mitochondria.

30 September 2017

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Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis

30 September 2017

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Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.

30 September 2017

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Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia

30 September 2017

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30 September 2017

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A pilot study to examine the effect of chronic treatment with immunosuppressive drugs on mucociliary clearance in a vagotomized murine model

30 September 2017

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TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema

30 September 2017

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A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK

30 September 2017

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Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

30 September 2017

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CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland

30 September 2017

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A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.

30 September 2017

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Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice

30 September 2017

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Genetics of sputum gene expression in chronic obstructive pulmonary disease

30 September 2017

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The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

30 September 2017

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Structure-function relations in an elastase-induced mouse model of emphysema

30 September 2017

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Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.

30 September 2017

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Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

30 September 2017

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Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.

30 September 2017

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Two to tango: regulation of Mammalian iron metabolism

30 September 2017

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Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema

30 September 2017

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Gene expression profiling in vastus lateralis muscle during an acute exacerbation of COPD.

30 September 2017

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Variants in FAM13A are associated with chronic obstructive pulmonary disease

30 September 2017

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In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2.

30 September 2017

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Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages

30 September 2017

1 reference

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Smoking is associated with shortened airway cilia

30 September 2017

1 reference

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Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

30 September 2017

1 reference

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Genome-wide association study identifies five loci associated with lung function

30 September 2017

1 reference

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Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Comparison of two quantitative methods of discerning airspace enlargement in smoke-exposed mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Neutrophil-mediated lung permeability and host defense proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Comparative assessment of the quadriceps and the diaphragm in patients with COPD.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

A genome-wide association study of pulmonary function measures in the Framingham Heart Study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Gene set enrichment analysis using linear models and diagnostics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

3D 3He diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Pulmonary epithelium, cigarette smoke, and chronic obstructive pulmonary disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Adjusting batch effects in microarray expression data using empirical Bayes methods

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Mitoferrin is essential for erythroid iron assimilation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Finding community structure in very large networks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

The nature of small-airway obstruction in chronic obstructive pulmonary disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

DAVID: Database for Annotation, Visualization, and Integrated Discovery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Systemic inflammation up-regulates serum hepcidin in exacerbations and stabile chronic obstructive pulmonary disease.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

The clinical significance of anaemia and disturbed iron homeostasis in chronic respiratory failure.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Interleukin-6 neutralization alleviates pulmonary inflammation in mice exposed to cigarette smoke and poly(I:C).

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Long-term treatment with deferiprone enhances left ventricular ejection function when compared to deferoxamine in patients with thalassemia major.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Anti-interleukin-33 inhibits cigarette smoke-induced lung inflammation in mice

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Multiple determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Quantitative characterization of airspace enlargement in emphysema

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Fluorescence analysis of the labile iron pool of mammalian cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Iron Regulatory Proteins Secure Mitochondrial Iron Sufficiency and Function

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)

4 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742374

Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury

4 December 2018

1 reference

12 December 2020

Short-term cigarette smoke exposure leads to metabolic alterations in lung alveolar cells

1 reference

12 December 2020

Cytochrome oxidase activity and mitochondrial gene expression in skeletal muscle of patients with chronic obstructive pulmonary disease

1 reference

12 December 2020

Lung mucociliary clearance

1 reference

12 December 2020

HIF1A signaling selectively supports proliferation of breast cancer in the brain

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.4021

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.4021

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

26752519

1 reference