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PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
scientific article published on 31 December 2015
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Europe PubMed Central
PMC publication ID
4743695
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26721933%20AND%20SRC:MED&resulttype=core&format=json
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3 March 2020
title
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease
(English)
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Europe PubMed Central
PMC publication ID
4743695
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26721933%20AND%20SRC:MED&resulttype=core&format=json
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3 March 2020
main subject
Alzheimer's disease
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author
George Perry
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3
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4743695
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26721933%20AND%20SRC:MED&resulttype=core&format=json
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3 March 2020
Jesús Ávila de Grado
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4
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4743695
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3 March 2020
Vega García-Escudero
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5
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4743695
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3 March 2020
Ricardo Gargini
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Ricardo Gargini
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4743695
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3 March 2020
author name string
Patricia Martín-Maestro
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1
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Europe PubMed Central
PMC publication ID
4743695
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3 March 2020
publication date
31 December 2015
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4743695
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3 March 2020
published in
Human Molecular Genetics
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4743695
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3 March 2020
volume
25
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4743695
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3 March 2020
issue
4
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Europe PubMed Central
PMC publication ID
4743695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26721933%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
page(s)
792-806
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Europe PubMed Central
PMC publication ID
4743695
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3 March 2020
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p62/SQSTM1 functions as a signaling hub and an autophagy adaptor
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PubMed Central
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PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
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PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
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Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics
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Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain
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Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells
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30 September 2017
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
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PubMed Central
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30 September 2017
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
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30 September 2017
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30 September 2017
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
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30 September 2017
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
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30 September 2017
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4743695
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30 September 2017
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.
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30 September 2017
Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions
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Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains.
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30 September 2017
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
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Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation
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30 September 2017
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Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells
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30 September 2017
Neuropathological stageing of Alzheimer-related changes
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28 June 2018
Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models
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28 June 2018
Autophagocytosis of mitochondria is prominent in Alzheimer disease
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4743695
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28 June 2018
Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients
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28 June 2018
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28 June 2018
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21 September 2018
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1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4743695
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21 September 2018
Age, neuropathology, and dementia
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4743695
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Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4743695
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21 September 2018
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease
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21 September 2018
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1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4743695
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21 September 2018
Increased autophagic degradation of mitochondria in Alzheimer disease
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26721933
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26721933
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/HMG/DDV616
1 reference
stated in
Europe PubMed Central
PMC publication ID
4743695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26721933%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
PMC publication ID
4743695
1 reference
stated in
Europe PubMed Central
PMC publication ID
4743695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26721933%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
PubMed publication ID
26721933
1 reference
stated in
Europe PubMed Central
PMC publication ID
4743695
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26721933%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 March 2020
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