(Q36558133)

14 August 2017

1 reference

title

The nuclear receptor superfamily and drug discovery (English)

1 reference

14 August 2017

1 reference

John T Moore

1

1 reference

PubMed ID

16892386

14 August 2017

Jon L Collins

series ordinal

2

1 reference

PubMed ID

16892386

14 August 2017

Kenneth H Pearce

series ordinal

3

1 reference

14 August 2017

1 May 2006

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14 August 2017

1 reference

14 August 2017

1

1 reference

14 August 2017

5

1 reference

14 August 2017

504-523

1 reference

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

14 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

Advances in the science of estrogen receptor modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

Eplerenone: a selective aldosterone receptor antagonist for patients with heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

The evolution of the nuclear receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

A unified nomenclature system for the nuclear receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

A canonical structure for the ligand-binding domain of nuclear receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Nuclear-receptor interactions on DNA-response elements

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Transcription factor interactions: selectors of positive or negative regulation from a single DNA element.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The pursuit of differentiated ligands for the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

THE TOTAL SYNTHESIS OF CORTISONE

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Tamoxifen: a most unlikely pioneering medicine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Cloning of the human glucocorticoid receptor cDNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Cloning of the human oestrogen receptor cDNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Cloning of the human estrogen receptor cDNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Sequence and expression of human estrogen receptor complementary DNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The RXR heterodimers and orphan receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Orphan nuclear receptors--new ligands and new possibilities.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Identification of a photoreceptor cell-specific nuclear receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

How many nuclear hormone receptors are there in the human genome?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Bile acids: natural ligands for an orphan nuclear receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Atomic structure of progesterone complexed with its receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Cloning of a novel receptor expressed in rat prostate and ovary

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

A structural biologist's view of the oestrogen receptor.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Molecular basis of agonism and antagonism in the oestrogen receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Structural insights into the mode of action of a pure antiestrogen

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Crystal structure of the heterodimeric complex of LXR and RXR ligand-binding domains in a fully agonistic conformation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Steroid hormone receptors: an update

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Principles for modulation of the nuclear receptor superfamily

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Nuclear receptor coactivators

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Minireview: nuclear receptor coactivators--an update

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Core LXXLL motif sequences in CREB-binding protein, SRC1, and RIP140 define affinity and selectivity for steroid and retinoid receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Steroid receptor coactivator-1 is a histone acetyltransferase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The role of corepressors in transcriptional regulation by nuclear hormone receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

A transcriptional co-repressor that interacts with nuclear hormone receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Transcriptional cross-talk, the second mode of steroid hormone receptor action.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappa B and the glucocorticoid receptor.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Nongenomic actions of steroid hormones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Estrogen receptor-mediated cross-talk with growth factor signaling pathways

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Nuclear retinoid receptors and the transcription of retinoid-target genes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Nuclear receptors: integration of multiple signalling pathways through phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Estrogen receptor phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Raloxifene preserves bone strength and bone mass in ovariectomized rats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The Molecular Pharmacology of SERMs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Molecular determinants for the tissue specificity of SERMs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Differential SERM effects on corepressor binding dictate ERalpha activity in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic acid: a non-steroidal estrogen with functional selectivity for bone over uterus in rats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Selective estrogen receptor modulators

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

What pharmacologists can learn from recent advances in estrogen signalling

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta, in estrogen target tissues in vivo through the use of an ERalpha-selective ligand

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Structure-based design of estrogen receptor-beta selective ligands

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

DNA binding of the glucocorticoid receptor is not essential for survival

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Deflazacort: towards selective glucocorticoid receptor modulation?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Andropause: coming of age for an old concept?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Role of androgens in mild cognitive impairment and possible interventions during andropause

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

The androgen receptor: a potential target for therapy of prostate cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

A family-based approach reveals the function of residues in the nuclear receptor ligand-binding domain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Towards selectively modulating mineralocorticoid receptor function: lessons from other systems

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Peptide antagonists of the human estrogen receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Correlation between in vitro peptide binding profiles and cellular activities for estrogen receptor-modulating compounds.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Discovery of novel nuclear receptor modulating ligands: an integral role for peptide interaction profiling

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Comparison of proteomic and genomic analyses of the human breast cancer cell line T47D and the antiestrogen-resistant derivative T47D-r.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Identifying estrogen receptor alpha target genes using integrated computational genomics and chromatin immunoprecipitation microarray

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600006

7 January 2021

Identifiers

DOI

10.1002/CMDC.200600006

1 reference

14 August 2017

1 reference

PubMed ID

16892386