(Q36562273)

English

Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice

scientific article published on 19 October 2015

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

14 August 2017

Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice (English)

1 reference

Europe PubMed Central

14 August 2017

pancreatic cancer

1 reference

based on heuristic

inferred from title

author name string

Hironobu Takano

1

1 reference

Europe PubMed Central

14 August 2017

Toru Nakamura

2

1 reference

Europe PubMed Central

14 August 2017

Takahiro Tsuchikawa

3

1 reference

Europe PubMed Central

14 August 2017

Toshihiro Kushibiki

4

1 reference

Europe PubMed Central

14 August 2017

Kouji Hontani

5

1 reference

Europe PubMed Central

14 August 2017

Kazuho Inoko

6

1 reference

Europe PubMed Central

14 August 2017

Mizuna Takahashi

7

1 reference

Europe PubMed Central

14 August 2017

Shoki Sato

8

1 reference

Europe PubMed Central

14 August 2017

Hirotake Abe

9

1 reference

Europe PubMed Central

14 August 2017

Shintaro Takeuchi

10

1 reference

Europe PubMed Central

14 August 2017

Nagato Sato

11

1 reference

Europe PubMed Central

14 August 2017

Kei Hiraoka

12

1 reference

Europe PubMed Central

14 August 2017

Hiroshi Nishihara

13

1 reference

Europe PubMed Central

14 August 2017

Toshiaki Shichinohe

14

1 reference

Europe PubMed Central

14 August 2017

Satoshi Hirano

15

1 reference

Europe PubMed Central

14 August 2017

language of work or name

0 references

publication date

19 October 2015

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

6

1 reference

Europe PubMed Central

14 August 2017

38

1 reference

Europe PubMed Central

14 August 2017

41063-41076

1 reference

Europe PubMed Central

14 August 2017

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

miR-141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling EphA2 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Cancer statistics, 2014

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Clinical and pathologic features influencing survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

EphA4 is a prognostic factor in gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Down-regulation of Human Leukocyte Antigen class I heavy chain in tumors is associated with a poor prognosis in advanced esophageal cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Eph-ephrin bidirectional signaling in physiology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Zonal heterogeneity for gene expression in human pancreatic carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

The role of ephrins and Eph receptors in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

The Ki-67 protein: from the known and the unknown

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Cellular survival: a play in three Akts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

A novel putative tyrosine kinase receptor encoded by the eph gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

30 September 2017

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

28 June 2018

Constitutive activation of the Raf-MAPK pathway causes negative feedback inhibition of Ras-PI3K-AKT and cellular arrest through the EphA2 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

28 June 2018

The Ephrin-A5/EphA4 Interaction Modulates Neurogenesis and Angiogenesis by the p-Akt and p-ERK Pathways in a Mouse Model of TLE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

21 September 2018

Pathological and clinical impact of neoadjuvant chemoradiotherapy using full-dose gemcitabine and concurrent radiation for resectable pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

21 September 2018

Genome-wide profiling of gene expression in 29 normal human tissues with a cDNA microarray.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

21 September 2018

Suppression of pancreatic cancer by the dominant negative ras mutant, N116Y.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4747390

21 September 2018

Pancreatic carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26516928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The epidemiology of pancreatic cancer in the United States: changes below the surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/26516928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26516928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lymph node ratio is the strongest prognostic factor after resection of pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26516928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/26516928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal Growth Factor Impairs the Cytochrome C/Caspase-3 Apoptotic Pathway Induced by Transforming Growth Factorβ in Rat Fetal Hepatocytes Via a Phosphoinositide 3-Kinase–Dependent Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/26516928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26516928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.18632/ONCOTARGET.5729

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

ResearchGate publication ID

0 references

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