(Q36563545)

14 August 2017

1 reference

title

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation (English)

1 reference

14 August 2017

3

Fiona Powrie

1 reference

14 August 2017

Ana Izcue

1

1 reference

PubMed ID

16903919

14 August 2017

Janine L Coombes

series ordinal

2

1 reference

14 August 2017

1 August 2006

1 reference

14 August 2017

Immunological Reviews

1 reference

14 August 2017

212

1 reference

14 August 2017

256-271

1 reference

Transcription factors in autoimmunity

14 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

The immunological and genetic basis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Organizing a mucosal defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Isolated lymphoid follicles can function as sites for induction of mucosal immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Collaboration of epithelial cells with organized mucosal lymphoid tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

TLR signaling in the gut in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Regulatory T cells in the control of immune pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

An essential role for Scurfin in CD4+CD25+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Neuropilin-1: a surface marker of regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Regulatory T cells and mechanisms of immune system control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Regulatory T cells: friend or foe in immunity to infection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Transforming growth factor-beta regulation of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Interleukin-10-deficient mice develop chronic enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

A molecular perspective of CTLA-4 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

CTLA-4-Ig regulates tryptophan catabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Modulation of tryptophan catabolism by regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Innate immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Homing and cellular traffic in lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Lymphocyte homing to the gut: attraction, adhesion, and commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ + gut intraepithelial lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Retinoic acid imprints gut-homing specificity on T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Mechanisms of binding of cutaneous lymphocyte-associated antigen-positive and alphaebeta7-positive lymphocytes to oral and skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Integrin alpha E(CD103)beta 7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-cadherin-independent interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Essential role for CD103 in the T cell-mediated regulation of experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

Cutting Edge: TGF- Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00423.X

10.1111/J.0105-2896.2006.00423.X

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16903919