(Q36568506)

15 August 2017

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title

Systemic and brain metabolic dysfunction as a new paradigm for approaching Alzheimer's dementia (English)

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15 August 2017

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Vincenzo Giordano

1

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15 August 2017

Gianfranco Peluso

2

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15 August 2017

Maurizio Iannuccelli

3

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15 August 2017

Paola Benatti

4

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15 August 2017

Raffaella Nicolai

5

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15 August 2017

Menotti Calvani

6

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15 August 2017

language of work or name

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17 August 2006

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15 August 2017

published in

Neurochemical Research

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15 August 2017

volume

32

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15 August 2017

issue

4-5

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15 August 2017

page(s)

555-567

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Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer's disease.

15 August 2017

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Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study

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Insulin resistance and risk for stroke

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Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.

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Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease

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12 December 2020

Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease

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12 December 2020

Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease

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12 December 2020

Do oxysterols control cholesterol homeostasis?

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12 December 2020

The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.

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12 December 2020

Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis

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12 December 2020

Identification of two distinct synucleins from human brain

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12 December 2020

Cerebrospinal fluid acetylcholinesterase activity in senile dementia of the Alzheimer type.

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12 December 2020

Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function

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12 December 2020

INTERLEUKIN-6 PROMOTER POLYMORPHISM AND LATE-ONSET ALZHEIMER's DISEASE IN THE FINNISH POPULATION

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12 December 2020

Low serum vitamin B12 in Alzheimer-type dementia

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12 December 2020

Selective loss of central cholinergic neurons in Alzheimer's disease

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12 December 2020

A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease.

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12 December 2020

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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12 December 2020

ACRP30, a new hormone controlling fat and glucose metabolism

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12 December 2020

Vitamin B12 levels in serum and cerebrospinal fluid of people with Alzheimer's disease.

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12 December 2020

Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease.

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12 December 2020

Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E.

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12 December 2020

Cardiovascular risk factors and Alzheimer's disease

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12 December 2020

Early-life risk factors for Alzheimer disease

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12 December 2020

Ghrelin: structure and function

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12 December 2020

Weight loss, nutritional status and physical activity in patients with Alzheimer's disease. A controlled study

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

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12 December 2020

Ghrelin induces adiposity in rodents

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12 December 2020

Localization of leptin receptor in the human brain

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12 December 2020

Central nervous system control of food intake

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12 December 2020

Vitamin E concentrations in human brain of patients with Alzheimer's disease, fetuses with Down's syndrome, centenarians, and controls

1 reference

12 December 2020

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

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12 December 2020

Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes

1 reference

12 December 2020

Metabolic alterations common to neural and non-neural cells in Alzheimer's disease

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12 December 2020

The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins

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12 December 2020

Adiponectin and adiponectin receptors

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12 December 2020

Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals.

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12 December 2020

Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease

1 reference

12 December 2020

Intravenous glucose intake independently related to intensive care unit and hospital mortality: an argument for glucose toxicity in critically ill patients

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12 December 2020

Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents

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12 December 2020

Risk factor groupings related to insulin resistance and their synergistic effects on subclinical atherosclerosis: the atherosclerosis risk in communities study

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12 December 2020

Potential roles of insulin and IGF-1 in Alzheimer's disease.

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12 December 2020

Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease

1 reference

12 December 2020

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study

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12 December 2020

Carnitine replacement in end-stage renal disease and hemodialysis

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12 December 2020

Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration

1 reference

12 December 2020

Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta

1 reference

12 December 2020

Tauists, Baptists, Syners, Apostates, and new data

1 reference

12 December 2020

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

1 reference

12 December 2020

Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease

1 reference

12 December 2020

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

1 reference

12 December 2020

Mitochondrial function in brain tissue in primary degenerative dementia.

1 reference

12 December 2020

Insulin-like growth factor I and Alzheimer's disease: therapeutic prospects?

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12 December 2020

Human red blood cell choline uptake with age and Alzheimer's disease.

1 reference

12 December 2020

Mitochondrial abnormalities in Alzheimer brain: mechanistic implications

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12 December 2020

Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

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12 December 2020

Ghrelin does not influence gastric emptying in obese subjects.

1 reference

12 December 2020

Alzheimer's disease: a 'cobalaminergic' hypothesis

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12 December 2020

The involvement of lipid rafts in Alzheimer's disease

1 reference

12 December 2020

Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients

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12 December 2020

Neurofibrillary tangles of paired helical filaments

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12 December 2020

EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION. I. LIGHT MICROSCOPIC OBSERVATIONS

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12 December 2020

Acetyl-L-carnitine and Alzheimer's disease: pharmacological considerations beyond the cholinergic sphere

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12 December 2020

EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION 2. ELECTRON MICROSCOPY, PHOSPHATASE HISTOCHEMISTRY AND ELECTRON PROBE ANALYSIS

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12 December 2020

The dementia patient: evaluation and care.

1 reference

12 December 2020

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

1 reference

12 December 2020

Leptin: a potential cognitive enhancer?

1 reference

12 December 2020

Acetyl-L-carnitine in the treatment of mildly demented elderly patients

1 reference

12 December 2020

Alzheimer's disease. A metabolic systems degeneration?

1 reference

12 December 2020

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

1 reference

12 December 2020

Slowed synthesis of DNA and methionine is a pathogenetic mechanism common to dementia in Down's syndrome, AIDS and Alzheimer's disease?

1 reference

12 December 2020

24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells

1 reference

12 December 2020

Restoration of adiponectin pulsatility in severely obese subjects after weight loss

1 reference

12 December 2020

Normal replicative lifespan of Alzheimer skin fibroblasts

1 reference

12 December 2020

Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

1 reference

12 December 2020

Correlation between scores for dementia and counts of 'senile plaques' in cerebral grey matter of elderly subjects.

1 reference

12 December 2020

The metabolic syndrome, inflammation, and risk of cognitive decline

1 reference

12 December 2020

Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia

1 reference

12 December 2020

A neuronal antigen in the brains of Alzheimer patients

1 reference

12 December 2020

Immunoglobulin and other proteins in the cerebrospinal fluid of patients with Alzheimer's disease

1 reference

12 December 2020

Brain cholesterol: long secret life behind a barrier.

1 reference

12 December 2020

Amyloidosis, expression and cause of presenile and senile mental and physical regression. A revision of the amyloid problem (author's transl)

1 reference

12 December 2020

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

1 reference

12 December 2020

Alzheimer's disease: interactions between cholinergic functions and beta-amyloid

1 reference

12 December 2020

Cerebral ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile dementia of the Alzheimer type

1 reference

12 December 2020

The relationship between quantitative measures of dementia and of degenerative changes in the cerebral grey matter of elderly subjects.

1 reference

12 December 2020

Apolipoprotein E in neurology

1 reference

12 December 2020

Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease.

1 reference

12 December 2020

Identification of insulin-responsive regions in the HMG-CoA reductase promoter

1 reference

12 December 2020

Biosynthesis of cholest-5-ene-3beta, 24-diol (cerebrosterol) by bovine cerebral cortical microsomes

1 reference

12 December 2020

Cognition and synaptic plasticity in diabetes mellitus

1 reference

12 December 2020

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve

1 reference

12 December 2020

Nonneural Markers in Alzheimer Disease

1 reference

12 December 2020

Relationship between nutrition and dementia in the elderly

1 reference

12 December 2020

beta-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease

1 reference

12 December 2020

Galanin in Alzheimer disease

1 reference

12 December 2020

Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus

1 reference

12 December 2020

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

1 reference

12 December 2020

Comparison of two cognitive rating scales in medically ill patients

1 reference

12 December 2020

Alzheimer's disease-do tauists and baptists finally shake hands?

1 reference

12 December 2020

Aluminium, neurofibrillary degeneration and Alzheimer's disease

1 reference

12 December 2020

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

1 reference

12 December 2020

Carnitine, carnitine acetyltransferase, and glutathione in Alzheimer brain.

1 reference

12 December 2020

Ghrelin as a potential anti-obesity target

1 reference

12 December 2020

Is Alzheimer's disease a mitochondrial disorder?

1 reference

12 December 2020

Concentrations of alpha-tocopherol and its quinone derivative in cerebrospinal fluid from patients with vascular dementia of the Binswanger type and Alzheimer type dementia

1 reference

12 December 2020

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

1 reference

12 December 2020

Central actions of adipocyte hormones

1 reference

12 December 2020

Clinical Issues of Cognitive Enhancers in Alzheimer Disease

1 reference

12 December 2020

Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration

1 reference

12 December 2020

Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E

1 reference

12 December 2020

Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease

1 reference

12 December 2020

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration

1 reference

12 December 2020

Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta.

1 reference

12 December 2020

Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease

1 reference

12 December 2020

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease

1 reference

12 December 2020

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1 reference

12 December 2020

Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase gene transcription

1 reference

12 December 2020

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1 reference

12 December 2020

1 reference

12 December 2020

1 reference

12 December 2020

[Isolation, constitution and biological significance of cerebrosterol, a companion of cholesterol in the horse brain]

1 reference

12 December 2020

Vitamin E in brains of patients with Alzheimer's disease and Down's syndrome

1 reference

12 December 2020

Cluster analysis of cognitive performance in elderly and demented subjects.

1 reference

12 December 2020

AdipoQ is a novel adipose-specific gene dysregulated in obesity

1 reference

12 December 2020

Abnormalities of mitochondrial enzymes in Alzheimer disease

1 reference

12 December 2020

Expression of 'Alzheimer Antigens' in Cultured Skin Fibroblasts

1 reference

12 December 2020

High-density lipoprotein cholesterol in differential diagnosis of senile dementia.

1 reference

12 December 2020

Peripheral markers of Alzheimer's disease.

1 reference

12 December 2020

Diminished mitogen-induced calcium uptake by lymphocytes from Alzheimer patients.

1 reference

12 December 2020

Introducing a new component of the metabolic syndrome: low cholesterol absorption.

1 reference

12 December 2020

[Isolation of cerebrosterol from human brain]

1 reference

12 December 2020

Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

1 reference

12 December 2020

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

1 reference

12 December 2020

Diabetes contributes to cholesterol metabolism regardless of obesity

1 reference

12 December 2020

Disruption of adiponectin causes insulin resistance and neointimal formation

1 reference

12 December 2020

Phosphofructokinase activity in fibroblasts from patients with Alzheimer's disease and age- and sex-matched controls

1 reference

12 December 2020

Brain Aluminum Distribution in Alzheimer's Disease and Experimental Neurofibrillary Degeneration

1 reference

12 December 2020

Phosphofructokinase activity in the brain in Alzheimer's disease

1 reference

12 December 2020

Vitamin E and donepezil for the treatment of mild cognitive impairment

1 reference

12 December 2020

Acetylcholine in mind: a neurotransmitter correlate of consciousness?

1 reference

12 December 2020

Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise

1 reference

12 December 2020

Folic acid with or without vitamin B12 for cognition and dementia

1 reference

12 December 2020

Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells

1 reference

12 December 2020

The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

1 reference

12 December 2020

Circulating leptin levels and weight loss in Alzheimer's disease patients

1 reference

12 December 2020

Ghrelin controls hippocampal spine synapse density and memory performance

1 reference

12 December 2020

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

1 reference

12 December 2020

Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin

1 reference

12 December 2020

Dual relation between leptin and cortisol in humans is disturbed in Alzheimer's disease.

1 reference

12 December 2020

Ghrelin-containing neuron in cerebral cortex and hypothalamus linked with the DVC of brainstem in rat.

1 reference

12 December 2020

Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease patients display gender dimorphism in circulating anorectic adipokines

1 reference

12 December 2020

Plasma concentrations of vitamins A and E and carotenoids in Alzheimer's disease

1 reference

12 December 2020

A life-course approach to the aetiology of late-onset dementias

1 reference

12 December 2020

A critical review of brain cholesterol metabolism

1 reference

12 December 2020

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.

1 reference

12 December 2020

Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody

1 reference

12 December 2020

Altered oxidation and signal transduction systems in fibroblasts from Alzheimer patients.

1 reference

12 December 2020

10.1007/S11064-006-9125-8

Identifiers

DOI

1 reference

15 August 2017

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