(Q43906989)

English

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

scientific article published in March 2002

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Alzheimer's disease

0 references

0 references

1 reference

based on heuristic

inferred from title

10

object named as

Mark P Mattson

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

author name string

Inna I Kruman

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

T S Kumaravel

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Althaf Lohani

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Ward A Pedersen

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Roy G Cutler

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Yuri Kruman

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Norman Haughey

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Jaewon Lee

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Michele Evans

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

language of work or name

0 references

publication date

1 March 2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

22

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1752-1762

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uracil misincorporation in human DNA detected using single cell gel electrophoresis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA strand breaks in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What counts in brain aging? Design-based stereological analysis of cell number

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA repair mechanisms for the recognition and removal of damaged DNA bases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of single-cell gel electrophoresis (SCGE) for quantitative analysis of neuronal DNA damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P53- and CD95-associated apoptosis in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential radiosensitivity of neurons and neuroglia of the hippocampus in the adult rabbit

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperhomocysteinaemia; with reference to its neuroradiological aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stroke risk factors and stroke prevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine and cardiovascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased DNA repair capacity in familial, but not in sporadic Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GADD45 is induced in Alzheimer's disease, and protects against apoptosis in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The comet assay: a comprehensive review

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional methionine synthase deficiency (cblE and cblG): clinical and biochemical heterogeneity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of postmitotic neurons to X-irradiation: implications for the role of DNA damage in neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Damage and repair of nerve cell DNA in toxic stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct detection of 8-oxodeoxyguanosine and 8-oxoguanine by avidin and its analogues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease cells exhibit defective repair of alkylating agent-induced DNA damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of methotrexate-induced growth inhibition, cell killing and DNA lesions in cultured L5178Y cells by the reduction of DNA repair efficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine and Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA replication precedes neuronal cell death in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ataxia telangiectasia mutated is essential during adult neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unscheduled DNA synthesis in various types of cells of the mouse brain in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for synaptic apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of folic acid in deficiency states and prevention of disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypersensitivity to ionizing radiation in cultured cells from Down syndrome patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptosomal plasma membrane transport of excitatory sulphur amino acid transmitter candidates: kinetic characterisation and analysis of carrier specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimutagenic role of base-excision repair enzymes upon free radical-induced DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of oxidative base DNA damage by a new biochemical assay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated plasma levels of homocysteine in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficient repair of DNA lesions in Alzheimer's disease fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate and carcinogenesis: an integrated scheme

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folic acid deficiency and cancer: mechanisms of DNA instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The efficiency of systematic sampling in stereology and its prediction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine and atherothrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of DNA Repair Linked to Neuroblastoma Differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate deficiency increases genetic damage caused by alkylating agents and gamma-irradiation in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folate deficiency beyond megaloblastic anemia: hyperhomocysteinemia and other manifestations of dysfunctional folate status

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/11880504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-05-01752.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880504%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q43906989&oldid=2104310719"