(Q36569379)

15 August 2017

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title

The role of heparan sulphate in inflammation (English)

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15 August 2017

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Christopher R Parish

1

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PubMed ID

16917509

15 August 2017

language of work or name

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18 August 2006

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Nature Reviews Immunology

15 August 2017

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15 August 2017

6

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15 August 2017

633-643

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15 August 2017

9

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Migration of leukocytes through the vessel wall and beyond

15 August 2017

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Glycan-dependent leukocyte adhesion and recruitment in inflammation

31 March 2020

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Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells

31 March 2020

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Transmigration through venular walls: a key regulator of leukocyte phenotype and function

31 March 2020

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Treatment of central nervous system inflammation with inhibitors of basement membrane degradation.

31 March 2020

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Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation

31 March 2020

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Order out of chaos: assembly of ligand binding sites in heparan sulfate

31 March 2020

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Heparan sulfate: growth control with a restricted sequence menu

31 March 2020

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Heparan sulfate: decoding a dynamic multifunctional cell regulator

31 March 2020

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Syndecans in inflammation

31 March 2020

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Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention

31 March 2020

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Heparan sulfate proteoglycans in glomerular inflammation.

31 March 2020

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Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns

31 March 2020

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Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165

31 March 2020

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Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds

31 March 2020

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Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 (fibroglycan) on human activated macrophages can regulate fibroblast growth factor action

31 March 2020

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Syndecan-4 as antithrombin receptor of human neutrophils

31 March 2020

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Syndecans serve as attachment receptors for human immunodeficiency virus type 1 on macrophages

31 March 2020

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Heparan Sulfate Proteoglycans Mediate Attachment and Entry of Human T-Cell Leukemia Virus Type 1 Virions into CD4+ T Cells

31 March 2020

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Syndecan-1 in B lymphoid malignancies

31 March 2020

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Endoglin expression on human microvascular endothelial cells association with betaglycan and formation of higher order complexes with TGF-beta signalling receptors

31 March 2020

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CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor

31 March 2020

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Heparan sulfate proteoglycan isoforms of the CD44 hyaluronan receptor induced in human inflammatory macrophages can function as paracrine regulators of fibroblast growth factor action

31 March 2020

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Expression of CD44v3 protein in human endothelial cells in vitro and in tumoral microvessels in vivo.

31 March 2020

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Endothelial cell expression of testican mRNA.

31 March 2020

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31 March 2020

Testican in human blood.

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Syndecans in tumor cell adhesion and signaling

31 March 2020

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Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control bindin

31 March 2020

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Interleukin-8 binds to syndecan-2 on human endothelial cells.

31 March 2020

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Basement membranes: structure, assembly and role in tumour angiogenesis

31 March 2020

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Still more complexity in mammalian basement membranes

31 March 2020

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Basement membrane assembly, stability and activities observed through a developmental lens.

31 March 2020

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Basement membrane proteoglycans: from cellar to ceiling

31 March 2020

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Growth factors in the extracellular matrix

31 March 2020

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Extracellular matrix and cytokines: a functional unit.

31 March 2020

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Structural diversity of heparan sulfate binding domains in chemokines

31 March 2020

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Collagen XVIII, a basement membrane heparan sulfate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein-1.

31 March 2020

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Identification of L-selectin binding heparan sulfates attached to collagen type XVIII.

31 March 2020

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Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells

31 March 2020

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Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents

31 March 2020

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Monocyte adhesion to activated aortic endothelium: role of L-selectin and heparan sulfate proteoglycans

31 March 2020

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Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins

31 March 2020

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Inhibition of selectin-mediated cell adhesion and prevention of acute inflammation by nonanticoagulant sulfated saccharides. Studies with carboxyl-reduced and sulfated heparin and with trestatin a sulfate

31 March 2020

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Low molecular weight heparin inhibits tumor necrosis factor alpha-induced leukocyte rolling

31 March 2020

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Glycosylation in the control of selectin counter-receptor structure and function

31 March 2020

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Ligands for L-selectin: homing, inflammation, and beyond

31 March 2020

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N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules

31 March 2020

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A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules

31 March 2020

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Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses

31 March 2020

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Increased leukocyte-endothelial interactions in syndecan-1-deficient mice involve heparan sulfate-dependent and -independent steps

31 March 2020

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Endogenous attenuation of allergic lung inflammation by syndecan-1.

31 March 2020

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Regulation of inositol phospholipid binding and signaling through syndecan-4.

31 March 2020

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Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha

31 March 2020

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Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).

31 March 2020

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Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH.

31 March 2020

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Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis

31 March 2020

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Heparanase mediates cell adhesion independent of its enzymatic activity

31 March 2020

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Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts

31 March 2020

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Regulation of protein function by glycosaminoglycans--as exemplified by chemokines

31 March 2020

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Chemokine-receptor interactions: GPCRs, glycosaminoglycans and viral chemokine binding proteins

31 March 2020

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Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV.

31 March 2020

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Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8.

31 March 2020

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Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines

31 March 2020

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Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

31 March 2020

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Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines

31 March 2020

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Interference with heparin binding and oligomerization creates a novel anti-inflammatory strategy targeting the chemokine system

31 March 2020

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Leukocyte extravasation: chemokine transport and presentation by the endothelium

31 March 2020

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Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury.

31 March 2020

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Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

31 March 2020

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Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines.

31 March 2020

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Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands

31 March 2020

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Lymphocyte trafficking across high endothelial venules: dogmas and enigmas

31 March 2020

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Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

31 March 2020

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Cell migration in the immune system: the evolving inter-related roles of adhesion molecules and proteinases

31 March 2020

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Heparanases and tumor metastasis

31 March 2020

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Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis

31 March 2020

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Role of endothelial heparanase in delayed-type hypersensitivity

31 March 2020

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Hydroxyl radicals depolymerize glomerular heparan sulfate in vitro and in experimental nephrotic syndrome

31 March 2020

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Comparative analysis of the ability of leucocytes, endothelial cells and platelets to degrade the subendothelial basement membrane: evidence for cytokine dependence and detection of a novel sulfatase

31 March 2020

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Cell surface localization of heparanase on macrophages regulates degradation of extracellular matrix heparan sulfate

31 March 2020

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Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans

31 March 2020

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Membrane proteases: roles in tissue remodeling and tumour invasion

31 March 2020

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Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion

31 March 2020

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A disaccharide that inhibits tumor necrosis factor alpha is formed from the extracellular matrix by the enzyme heparanase

31 March 2020

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Induction of a CXCL8 binding site on endothelial syndecan-3 in rheumatoid synovium

31 March 2020

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Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena

31 March 2020

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Inhibition by the soluble syndecan-1 ectodomains delays wound repair in mice overexpressing syndecan-1.

31 March 2020

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Syndecan-1 up-regulated by ephrinB2/EphB4 plays dual roles in inflammatory angiogenesis.

31 March 2020

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Syndecan-2 is expressed in the microvasculature of gliomas and regulates angiogenic processes in microvascular endothelial cells

31 March 2020

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Shedding of heparan sulfate proteoglycan by stimulated endothelial cells: evidence for proteolysis of cell-surface molecules

31 March 2020

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Plasminogen activator inhibitor-1 supports IL-8-mediated neutrophil transendothelial migration by inhibition of the constitutive shedding of endothelial IL-8/heparan sulfate/syndecan-1 complexes

31 March 2020

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Matrix metalloproteinase-dependent shedding of syndecan-3, a transmembrane heparan sulfate proteoglycan, in Schwann cells

31 March 2020

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Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells

31 March 2020

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Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site

31 March 2020

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Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor

31 March 2020

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A rapid quantitative assay for the detection of mammalian heparanase activity

31 March 2020

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Histidine-rich glycoprotein: A novel adaptor protein in plasma that modulates the immune, vascular and coagulation systems

31 March 2020

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Partial Suppression of Experimental Allergic Encephalomyelitis With Heparin

31 March 2020

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Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins

31 March 2020

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Effect of inhaled heparin on allergen-induced early and late asthmatic responses in patients with atopic asthma

31 March 2020

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Inhibition of delayed-type hypersensitivity by heparin depleted of anticoagulant activity

31 March 2020

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Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell-mediated immunity

31 March 2020

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Novel drug development opportunities for heparin.

31 March 2020

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Heparin-protein interactions

31 March 2020

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Phosphomannopentaose sulfate (PI-88): heparan sulfate mimetic with clinical potential in multiple vascular pathologies

31 March 2020

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siRNAs: mechanism of RNA interference, in vivo and potential clinical applications

31 March 2020

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The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation

31 March 2020

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Use of sulfated linked cyclitols as heparan sulfate mimetics to probe the heparin/heparan sulfate binding specificity of proteins

31 March 2020

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Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88).

31 March 2020

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Targeting of glycosaminoglycan-cytokine interactions as a novel therapeutic approach in allotransplantation

31 March 2020

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Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix

31 March 2020

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Heparan sulfate proteoglycans: intricate molecules with intriguing functions.

31 March 2020

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Expression and function of syndecan-4 in human platelets

31 March 2020

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Syndecan-4-dependent migration of human eosinophils.

31 March 2020

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Membrane-anchored proteoglycans of mouse macrophages: P388D1 cells express a syndecan-4-like heparan sulfate proteoglycan and a distinct chondroitin sulfate form.

31 March 2020

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Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression

31 March 2020

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The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles.

31 March 2020

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Cell-surface proteoglycan expression by lymphocytes from peripheral blood and gingiva in health and periodontal disease

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1918

1 reference

15 August 2017

1 reference

PubMed ID

16917509