(Q36572175)

15 August 2017

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title

The consequences of lysosomotropism on the design of selective cathepsin K inhibitors (English)

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15 August 2017

W Cameron Black

1

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15 August 2017

M David Percival

series ordinal

2

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15 August 2017

publication date

1 October 2006

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15 August 2017

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15 August 2017

volume

7

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15 August 2017

issue

10

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15 August 2017

page(s)

1525-1535

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Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Increased serum cathepsin S in patients with atherosclerosis and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Lysosomal cysteine proteases in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Lysosomal cysteine proteases: structure, function and inhibition of cathepsins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Osteopetrosis and osteoporosis: two sides of the same coin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Non-covalent cathepsin K inhibitors for the treatment of osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

The pH dependencies of individual rate constants in papain-catalyzed reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Crystal structure of human cathepsin K complexed with a potent inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Chemical approaches for functionally probing the proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Activity-based probes that target diverse cysteine protease families

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Dynamic imaging of protease activity with fluorescently quenched activity-based probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Irreversible inhibitors of serine, cysteine, and threonine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

The potential role of lysosomes in tissue distribution of weak bases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

The lysosomal cysteine proteases in MHC class II antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Peptide ketobenzoxazole inhibitors bound to cathepsin K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Synthesis, structure and conformation of partially-modified retro- and retro-inverso psi[NHCH(CF3)]Gly peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Identification of a potent and selective non-basic cathepsin K inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Acute effects of bisphosphonates on new and traditional markers of bone resorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200600149

21 January 2018

Identifiers

DOI

10.1002/CBIC.200600149

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15 August 2017

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