(Q36577650)

15 August 2017

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title

Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection (English)

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15 August 2017

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2

Michael R Betts

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15 August 2017

George Makedonas

1

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15 August 2017

25 August 2006

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Seminars in Immunopathology

15 August 2017

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15 August 2017

28

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15 August 2017

209-219

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15 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s00281-006-0025-4

15 August 2017

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High numbers of IL-2-producing CD8+ T cells during viral infection: correlation with stable memory development.

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Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity

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Functional heterogeneity of cytokines and cytolytic effector molecules in human CD8+ T lymphocytes

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Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors

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HIV-specific cytotoxic T lymphocytes in seropositive individuals

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12 December 2020

Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse.

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12 December 2020

Analysis of successful immune responses in persons infected with hepatitis C virus

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12 December 2020

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

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12 December 2020

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

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12 December 2020

Simian immunodeficiency virus (SIV) infection of a rhesus macaque induces SIV-specific CD8(+) T cells with a defect in effector function that is reversible on extended interleukin-2 incubation

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12 December 2020

Antibody neutralization and escape by HIV-1

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12 December 2020

A cytomegalovirus inhibitor of gamma interferon signaling controls immunoproteasome induction

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12 December 2020

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

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12 December 2020

Antiviral effects of recombinant tumour necrosis factor in vitro

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12 December 2020

Chemokine immunobiology in HIV-1 pathogenesis

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12 December 2020

TNF alpha and the TNF receptor superfamily: structure-function relationship(s).

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12 December 2020

Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection

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12 December 2020

Advantage of rare HLA supertype in HIV disease progression

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12 December 2020

Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

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12 December 2020

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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12 December 2020

Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands

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12 December 2020

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

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12 December 2020

The presence of high amounts of HBV-DNA in serum is associated with suppressed costimulatory effects of interleukin 12 on HBV-induced immune response

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12 December 2020

Virus interference. I. The interferon

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12 December 2020

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF

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12 December 2020

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

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12 December 2020

Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

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12 December 2020

Mechanism of lymphocyte-mediated cytotoxicity

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12 December 2020

NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase

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12 December 2020

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

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12 December 2020

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

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12 December 2020

Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques

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12 December 2020

Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

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12 December 2020

Immune defence in mice lacking type I and/or type II interferon receptors

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12 December 2020

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

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12 December 2020

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

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12 December 2020

Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

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12 December 2020

Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors.

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12 December 2020

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

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12 December 2020

Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy

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12 December 2020

Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia

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12 December 2020

IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression

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12 December 2020

Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.

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12 December 2020

Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice

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12 December 2020

Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity.

1 reference

12 December 2020

Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.

1 reference

12 December 2020

Chemokines and chemokine receptors: biology and clinical relevance in inflammation and AIDS.

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12 December 2020

Interferon-γ: an overview of signals, mechanisms and functions

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12 December 2020

Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections

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12 December 2020

An N-glycan within the human immunodeficiency virus type 1 gp120 V3 loop affects virus neutralization

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12 December 2020

Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load

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12 December 2020

Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells

1 reference

12 December 2020

The Evolution of Antigen-Specific CD8+T Cell Responses after Natural Primary Infection of Humans with Epstein-Barr Virus

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12 December 2020

Ex vivo identification, isolation and analysis of tumor-cytolytic T cells.

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12 December 2020

Sensitivity to inhibition by beta-chemokines correlates with biological phenotypes of primary HIV-1 isolates

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12 December 2020

Vaccination in humans generates broad T cell cytokine responses

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12 December 2020

Dissecting the host response to a gamma-herpesvirus

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12 December 2020

Molecular and functional profiling of memory CD8 T cell differentiation.

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12 December 2020

Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide.

1 reference

12 December 2020

Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte.

1 reference

12 December 2020

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

1 reference

12 December 2020

[Interferon-gamma up-regulates Fas expression and increases Fas-mediated apoptosis in tumor cell lines]

1 reference

12 December 2020

Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection

1 reference

12 December 2020

Rhesus macaques with high levels of vaccine induced IFN-gamma producing cells better control viral set-point following challenge with SIV239

1 reference

12 December 2020

Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells

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12 December 2020

Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.

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12 December 2020

Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells

1 reference

12 December 2020

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.

1 reference

12 December 2020

The antigenic structure of the HIV gp120 envelope glycoprotein

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12 December 2020

Biological functions of tumor necrosis factor cytokines and their receptors

1 reference

12 December 2020

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.

1 reference

12 December 2020

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

1 reference

12 December 2020

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

1 reference

12 December 2020

The tumor necrosis factor ligand and receptor families.

1 reference

12 December 2020

Identifying epitopes of HIV-1 that induce protective antibodies

1 reference

12 December 2020

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor

1 reference

12 December 2020

Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity

1 reference

12 December 2020

An endotoxin-induced serum factor that causes necrosis of tumors

1 reference

12 December 2020

Lysis of CD4+ T cells expressing HIV-1 gag peptides by gag-specific CD8+ cytotoxic T cells

1 reference

12 December 2020

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

1 reference

12 December 2020

Virus-specific and bystander CD8+ T-cell proliferation in the acute and persistent phases of a gammaherpesvirus infection

1 reference

12 December 2020

Immune response in mice that lack the interferon-gamma receptor

1 reference

12 December 2020

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

12 December 2020

A role for the proteasome regulator PA28alpha in antigen presentation

1 reference

12 December 2020

Distribution and functional analysis of memory antiviral CD8 T cell responses in HIV-1 and cytomegalovirus infections.

1 reference

12 December 2020

HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

1 reference

12 December 2020

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

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12 December 2020

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1 reference

12 December 2020

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1 reference

12 December 2020

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1 reference

12 December 2020

Human immunodeficiency virus type 1 replication, immune activation, and circulating cytotoxic T cells against uninfected CD4+ T cells

1 reference

12 December 2020

Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

1 reference

12 December 2020

Functional impairment of simian immunodeficiency virus-specific CD8+ T cells during the chronic phase of infection

1 reference

12 December 2020

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

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12 December 2020

Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies

1 reference

12 December 2020

Lymphocyte in vitro cytotoxicity: characterization of human lymphotoxin

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12 December 2020

Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs in human cells.

1 reference

12 December 2020

The role of cytoplasmic granules in cytotoxicity by large granular lymphocytes and cytotoxic T lymphocytes

1 reference

12 December 2020

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

1 reference

12 December 2020

HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity

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12 December 2020

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1 reference

12 December 2020

Interferon-gamma: the major mediator of resistance against Toxoplasma gondii

1 reference

12 December 2020

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

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12 December 2020

Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection

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12 December 2020

HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

1 reference

12 December 2020

Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes

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12 December 2020

TNF alpha is an effective therapeutic target for rheumatoid arthritis

1 reference

12 December 2020

Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2

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12 December 2020

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

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12 December 2020

Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo.

1 reference

12 December 2020

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

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12 December 2020

The activation of IL-2 transcription in L3T4+ and Lyt-2+ lymphocytes during virus infection in vivo.

1 reference

12 December 2020

Cytotoxic T-lymphocytes that kill autologous CD4+ lymphocytes are associated with CD4+ lymphocyte depletion in HIV-1 infection

1 reference

12 December 2020

Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation

1 reference

12 December 2020

Role of lymphokine-secreting CD8+ T cells in cytotoxic T lymphocyte responses against vaccinia virus

1 reference

12 December 2020

10.1007/S00281-006-0025-4

Identifiers

DOI

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15 August 2017

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PubMed ID

16932955