(Q36582006)

English

Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates

scientific article published on 17 November 2012

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates (English)

1 reference

Europe PubMed Central

15 August 2017

object named as

Alvin V Terry

5

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author name string

Patrick M Callahan

1

1 reference

Europe PubMed Central

15 August 2017

Elizabeth J Hutchings

2

1 reference

Europe PubMed Central

15 August 2017

Nancy J Kille

3

1 reference

Europe PubMed Central

15 August 2017

James M Chapman

4

1 reference

Europe PubMed Central

15 August 2017

publication date

17 November 2012

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Europe PubMed Central

15 August 2017

number of pages

12

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based on heuristic

inferred from page(s)

Neuropharmacology

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Europe PubMed Central

15 August 2017

67

1 reference

Europe PubMed Central

15 August 2017

201-212

1 reference

Europe PubMed Central

15 August 2017

Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562411

9 September 2017

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

1 reference

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Effectiveness of adding memantine to an Alzheimer dementia treatment regimen which already includes stable donepezil therapy: a critically appraised topic

1 reference

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Alzheimer's disease and age-related memory decline (preclinical)

1 reference

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Progressive cholinergic decline in Alzheimer's Disease: consideration for treatment with donepezil 23 mg in patients with moderate to severe symptomatology

1 reference

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Attention, executive functioning and memory in normal aged rhesus monkeys

1 reference

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Non-human primates: model animals for developmental psychopathology

1 reference

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Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery

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Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis

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Contributions of non-human primates to neuroscience research

1 reference

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Allosteric modulation of nicotinic acetylcholine receptors

1 reference

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An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

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Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

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A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

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Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys.

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The medial temporal lobe

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Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis

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The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development

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Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors

1 reference

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Nonhuman primates: a critical role in current disease research

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Cholinesterase inhibitors stabilize Alzheimer's disease

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On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

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Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

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The use of the Morris Water Maze in the study of memory and learning

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Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans

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Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor.

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Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease

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The neural basis of memory decline in aged monkeys

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Comparison of galantamine and donepezil for effects on nerve growth factor, cholinergic markers, and memory performance in aged rats

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Amphetamine-stimulated cortical acetylcholine release: role of the basal forebrain

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Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats

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Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

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Primate learning tasks reveal strong impairments in patients with presenile or senile dementia of the Alzheimer type.

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PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats.

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The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats.

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Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits

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Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys

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Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group.

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20 September 2018

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20 September 2018

The effects of donepezil in Alzheimer's disease - results from a multinational trial.

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Symposium overview: the use of delayed matching-to-sample procedures in studies of short-term memory in animals and humans.

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20 September 2018

Impaired recognition memory in patients with lesions limited to the hippocampal formation

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20 September 2018

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20 September 2018

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20 September 2018

Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats.

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The unique value of primate models in translational research

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Rivastigmine for Alzheimer's disease.

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21 October 2018

The neuropharmacological and neurochemical basis of place learning in the Morris water maze

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative behavioral and neurochemical activities of cholinergic antagonists in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23168113

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of dopaminergic neuronal system in dizocilpine-induced acetylcholine release in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23168113

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-human primates: essential partners in biomedical research

1 reference

https://pubmed.ncbi.nlm.nih.gov/23168113

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The great primate debate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23168113

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/23168113

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NEUROPHARM.2012.10.019

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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