(Q36584618)

15 August 2017

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors (English)

1 reference

15 August 2017

Sveva Pelliccia

10

0 references

Ilaria Granata

Ilaria Granata

13

0 references

Amalia Porta

Amalia Porta

14

0 references

Marianna Nalli

Marianna Nalli

9

0 references

Alessandra Soriani

Alessandra Soriani

16

0 references

Eleonora Da Pozzo

Eleonora Da Pozzo

11

0 references

Giuseppe La Regina

Giuseppe La Regina

1

0 references

Patrizia Lavia

Patrizia Lavia

30

0 references

Romano Silvestri

Romano Silvestri

32

0 references

Andrea Brancale

Andrea Brancale

23

0 references

Ettore Novellino

Ettore Novellino

31

0 references

Claudia Martini

Claudia Martini

28

0 references

Angela Santoni

18

Angela Santoni

1 reference

15 August 2017

2

Ruoli Bai

1 reference

15 August 2017

6

Francesco Piscitelli

1 reference

15 August 2017

17

Maria Luisa Iannitto

1 reference

15 August 2017

24

Giulio Dondio

1 reference

15 August 2017

26

Mario Varasi

1 reference

15 August 2017

27

Ciro Mercurio

1 reference

15 August 2017

29

Ernest Hamel

1 reference

15 August 2017

7

Valeria Famiglini

1 reference

15 August 2017

25

Stefania Vultaggio

1 reference

15 August 2017

5

Antonio Coluccia

1 reference

15 August 2017

Whilelmina Maria Rensen

3

1 reference

15 August 2017

Erica Di Cesare

4

1 reference

15 August 2017

Alessia Reggio

8

1 reference

15 August 2017

Barbara Costa

12

1 reference

15 August 2017

Bruno Maresca

15

1 reference

15 August 2017

Junjie Li

19

1 reference

15 August 2017

Marlein Miranda Cona

20

1 reference

15 August 2017

Feng Chen

21

1 reference

15 August 2017

Yicheng Ni

22

1 reference

15 August 2017

language of work or name

English

0 references

publication date

27 December 2012

1 reference

Journal of Medicinal Chemistry

15 August 2017

1 reference

15 August 2017

56

1 reference

15 August 2017

1

1 reference

15 August 2017

123-149

1 reference

describes a project that uses

15 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3563301/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Metal-Free Coupling of Azoles with 2- and 3-Haloindoles Providing Access to Novel 2- or 3-(Azol-1-yl)indole Derivatives

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

How do anti-mitotic drugs kill cancer cells?

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Death through a tragedy: mitotic catastrophe

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Newer cytotoxic agents: attacking cancer broadly

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Mitotic drug targets and the development of novel anti-mitotic anticancer drugs

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Medicinal chemistry of combretastatin A4: present and future directions.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Visualization of mitochondrial membrane potential and reactive oxygen species via double staining

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Understanding microtubule dynamics for improved cancer therapy.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Pharmaceutical design of antimitotic agents based on combretastatins.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

The clinical development of new mitotic inhibitors that stabilize the microtubule

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Microtubules as a target for anticancer drugs

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

High-resolution model of the microtubule

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Liver tumor model with implanted rhabdomyosarcoma in rats: MR imaging, microangiography, and histopathologic analysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Arylthioindoles, potent inhibitors of tubulin polymerization.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Substituent effects on the reaction of beta-benzoylalanines with Pseudomonas fluorescens kynureninase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Comparison between nonspecific and necrosis-avid gadolinium contrast agents in vascular disrupting agent-induced necrosis of rodent tumors at 3.0T.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Mitotic catastrophe: a mechanism for avoiding genomic instability.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)pipe

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Attenuation of WAF1/Cip1 expression by an antisense adenovirus expression vector sensitizes glioblastoma cells to apoptosis induced by chemotherapeutic agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Open Vessel and Cooling while Heating Microwave-Assisted Synthesis of Pyridinyl N-Aryl Hydrazones

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3563301

Autoxidation of hydrazones. Some new insights

4 December 2018

1 reference

12 December 2020

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

1 reference

12 December 2020

Easily accessible and highly tunable indolyl phosphine ligands for Suzuki-Miyaura coupling of aryl chlorides

1 reference

12 December 2020

Dirhodium(II)-catalyzed intramolecular C-H amination of aryl azides

1 reference

12 December 2020

Microtubule disassembly delays the G2-M transition in vertebrates

1 reference

12 December 2020

One-pot synthesis of 2-substituted indoles from 2-aminobenzyl phosphonium salts. A formal total synthesis of arcyriacyanin A

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM3013097

1 reference

15 August 2017

1 reference

15 August 2017

1 reference