(Q36596680)

15 August 2017

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title

Targeting caspase 8 to reduce the formation of metastases in neuroblastoma (English)

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15 August 2017

Amy E McKee

1

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15 August 2017

Carol J Thiele

series ordinal

2

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15 August 2017

language of work or name

English

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publication date

1 October 2006

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Expert Opinion on Therapeutic Targets

15 August 2017

published in

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15 August 2017

volume

10

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15 August 2017

issue

5

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15 August 2017

page(s)

703-708

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Potentiation of neuroblastoma metastasis by loss of caspase-8.

15 August 2017

cites work

1 reference

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The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression

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The IGF axis and programmed cell death

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

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Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis

21 January 2018

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Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis

21 January 2018

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Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

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Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

21 January 2018

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

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Dissecting Fas signaling with an altered-specificity death-domain mutant: requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation

21 January 2018

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The three-dimensional solution structure and dynamic properties of the human FADD death domain

21 January 2018

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Pro-caspase-3 is a major physiologic target of caspase-8.

21 January 2018

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The molecular basis and potential role of survivin in cancer diagnosis and therapy

21 January 2018

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Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death

21 January 2018

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The survivin:Fas ratio is predictive of recurrent disease in neuroblastoma

21 January 2018

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Survivin mRNA levels are associated with biology of disease and patient survival in neuroblastoma: a report from the children's oncology group

21 January 2018

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IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway.

21 January 2018

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Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter

21 January 2018

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Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells

21 January 2018

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FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

21 January 2018

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Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade

21 January 2018

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Caspase 8L, a novel inhibitory isoform of caspase 8, is associated with undifferentiated neuroblastoma.

21 January 2018

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Halting neuroblastoma metastasis by controlling integrin-mediated death.

21 January 2018

1 reference

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10.1517/14728222.10.5.703

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference